1
David R Sarver, Barry L Eppley, Keith R D Alessio, William S Pietrzak, Thomas W Sander: Method and apparatus for securing adjacent bone portions. October 29, 1996: US05569250 (111 worldwide citation)

A biocompatible osteosynthesis plate operable for being enhanced in a substantially secured relation to a plurality of adjacent bone portions is provided. The biocompatible osteosynthesis plate includes an elongated section having a top face and a bottom face, at least one fastener opening disposed ...


2
Keith R D Alessio, Gary F Prokop, Leonard F Czuba, Carl E Behrend, Peter J Kopec: Package assembly with applicator and container for adhesive materials. Closure Medical Corporation, Hutchison & Mason PLLC, November 1, 2005: US06960040 (33 worldwide citation)

A package assembly or kit can be used in conjunction with storing and dispensing adhesive materials. The package assembly can include an enclosure in which an applicator and a container may be positioned. The container contains adhesive material. The enclosure may include a base and a cover. The bas ...


3
Keith R D Alessio: Halogenated polymeric containers for 1, 1-disubstituted monomer compositions. Closure Medical Corporation, Hutchison & Mason PLLC, May 24, 2005: US06896838 (20 worldwide citation)

A container made without employing a mold release agent, comprised of halogenated polymeric material provides an extended shelf-life for 1,1-disubstituted ethylene adhesive monomer compositions.


4
Eric J Boone, Keith R D Alessio, John F Goodman, Scott A Keplinger, Anthony S Voiers, Daniel J Tomko, William F Johnson Jr: Applicators, dispensers and methods for mixing, dispensing and applying adhesive or sealant material and another material. Closure Medical, April 14, 2009: US07516872 (13 worldwide citation)

An applicator/dispenser for dispensing, mixing and/or applying a polymerizable monomeric adhesive or sealant material comprises: a body portion; an actuator movable relative to the body portion; a cavity in the body portion; and a piercing or breaking portion on the actuator. Movement of the actuato ...


5
Kenneth E Stockman, Michael A Carnahan, Keith R D Alessio, Mark W Grinstaff: Crosslinked gels comprising polyalkyleneimines, and their uses as medical devices. HyperBranch Medical Technology, Dana M Gordon, Foley Hoag, July 19, 2016: US09393344 (1 worldwide citation)

One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polya ...


6
Jeffrey G Clark, Keith R D Alessio: Applicators for multiple component formulations and the like, and methods of use thereof. HyperBranch Medical Technology, Dana M Gordon, Alan W Steele, Foley Hoag, September 11, 2012: US08262608 (1 worldwide citation)

One aspect of the invention relates to an applicator system, and methods of use thereof, that can be used to house separately one or more liquids and one or more solids (e.g., components of a polymerizable hydrogel). In certain embodiments, the applicator systems are further designed to facilitate t ...


7
Keith R D Alessio, Andres Rivera, William M Cotter, Ibraheem T Badejo: Polymeric containers for 1,1-disubstituted monomer compositions. Closure Medical Corporation, Oliff & Berridge, February 27, 2003: US20030039781-A1 (1 worldwide citation)

A combination includes a pipette-shaped container formed from a polymeric material selected from polyethylene terephthalate, high density polyethylene, low density polyethylene, and mixtures thereof, and a 1,1 -disubstituted ethylene monomer adhesive composition sealed in the pipette-shaped containe ...


8
Keith R D Alessio, Jeffrey G Clark, Roy R B Attride, Wai N Chin, Robert M Colonna, Tomas Matusaitis, Todd J Taylor, Christopher R Yahnker: Self-contained medical applicators for multiple component formulations, and methods of use thereof. HyperBranch Medical Technology, Dana M Gordon, Foley Hoag, December 4, 2012: US08323262

Certain aspects of the invention relate to an applicator, and methods of use thereof, which can house multiple component formulations in separate material receptacles, which can then be easily reconstituted at time of use without any assembly by the user. A device of the invention can be used for, b ...


9
Keith R D Alessio, Matthew Justin Morton, John L Manhard, Stephen William Cline, Jared Daniel Goodnow Butlin, John Conn: Self-contained medical applicators for surgical sealants, and methods of use thereof. HyperBranch Medical Technology, Dana M Gordon, Foley Hoag, January 1, 2013: US08343183

Aspects of the invention relate to an applicator, and methods of use thereof, which can house multiple component formulations in separate material receptacles, which components can then be easily combined at the time of use without assembly by the user. In certain embodiments, a device of the invent ...


10
Anthony S Voiers, Keith R D Alessio, Jeffrey G Clark, Timothy P Hickey: Adhesive applicators with improved applicator tips. Oliff & Berridge, October 18, 2001: US20010031170-A1

An applicator for dispensing adhesive material includes a container body holding the adhesive material and an applicator tip configured to permit improved control and economy in application of the adhesive.



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