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Minoru Nakano, Toshinobu Uemura, Shinichi Morizane, Kiyoshi Okuda, Keiko Nakata: Method of producing a solid dispersion of the sparingly water-soluble drug, nilvadipine. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt, August 23, 1994: US05340591 (60 worldwide citation)

A solid dispersion and a method of producing a solid dispersion of a sparingly water-soluble drug characterized by mixing the sparingly water-soluble drug and a water-soluble polymer at a temperature where neither the water-soluble drug nor water-soluble polymer is melted.


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Kiyoshi Okuda, Kiyonori Okada, Kazumi Ohtomo, Keiko Nakata: Drug delivery device. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt, July 11, 1989: US04846801 (23 worldwide citation)

A drug delivery device includes a cylinder having a large diameter and a drug delivery member coaxially fitted to one end of the cylinder and in fluid communication therewith, the drug delivery member having a diameter substantially smaller than that of the cylinder. Drug delivery orifices are forme ...


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