1
Kawahara Yoshio: Process for the vapor phase rearrangement of hydrocarbons utilizing microwave energy. The Dow Chemical Company, May 16, 1972: US3663394 (22 worldwide citation)

A process for the vapor phase rearrangement of hydrocarbons is disclosed wherein said hydrocarbons are subjected to a microwave electrical discharge maintained by an incident power of from about 500 watts to about 5 megawatts, said feed having a residence time of no more than about 0.02 seconds, res ...


2
Nakai Yuta, Nakanishi Kazuo, Kawahara Yoshio, Ito Hisao, Kurahashi Osamu: Method for producing substances utilizing microorganisms. Ajinomoto, January 9, 2002: EP1170376-A1 (10 worldwide citation)

In a method for producing a target substance utilizing a microorganism comprising culturing the microorganism in a medium to produce and accumulate the target substance in the medium and collecting the target substance, there is used, as the microorganism, a mutant strain or a genetic recombinant st ...


3
Asakura Yoko, Usuda Yoshihiro, Tsujimoto Nobuharu, Kimura Eiichiro, Abe Chizu, Kawahara Yoshio, Nakamatsu Tsuyoshi, Kurahashi Osamu: -G(a)-ketoglutaric dehydrogenase gene. Ajinomoto, May 7, 1997: EP0771879-A1 (10 worldwide citation)

A coryneform L-glutamate producing bacterium deficient in alpha -ketoglutaric dehydrogenase activity; a process for producing L-glutamic acid by using the bacterium; a gene coding for an enzyme having an alpha -KGDH activity originating in the coryneform L-glutamate producing bacterium; a recombinan ...


4
Kimura Eiichiro, Kikuchi Yoshimi, Kawahara Yoshio, Goto Shinya, Kurahashi Osamu, Nakamatsu Tsuyoshi: Stress-tolerant microorganism and method of the production of fermentation product. Ajinomoto, September 16, 1998: EP0864654-A1 (9 worldwide citation)

A method of the fermentative production of useful substances such as amino acids with the use of a microorganism comprising culturing the microorganism in a medium and recovering the fermentation product thus accumulated in the medium, wherein the microorganism is the one to which a tolerance to the ...


5
Kimura Eiichiro, Asakura Yoko, Uehara Akinori, Inoue Sumio, Kawahara Yoshio, Yoshihara Yasuhiko, Nakamatsu Tsuyoshi: Process for producing l-lysine and l-glutamic acid by fermentation. Ajinomoto, June 25, 1997: EP0780477-A1 (8 worldwide citation)

A mutant strain having an ability to produce L-glutamic acid in the absence of any biotin action-suppressing agent in a medium containing an excessive amount of biotin is obtained by giving temperature sensitivity to a biotin action-suppressing agent to a coryneform L-glutamic acid-producing bacteri ...


6
Kimura Eiichiro, Abe Chizu, Kawahara Yoshio, Yoshihara Yasuhiko, Nakamatsu Tsuyoshi: Novel gene originating in corynebacterium and use thereof. Ajinomoto, January 8, 1997: EP0752472-A1 (7 worldwide citation)

The L-lysine productivity of an L-lysine-producing corynebacterium is enhanced by amplifying a novel gene originating in a corynebacterium and participating in L-glutamic acid production, while the L-glutamic acid productivity of an L-glutamic acid-producing corynebacterium is enhanced by suppressin ...


7
Matsuzaki Yumi, Kimura Eiichiro, Nakamatsu Tsuyoshi, Kurahashi Osamu, Kawahara Yoshio, Sugimoto Shinichi: Plasmid capable of autonomous replication in coryneform bacteria. Ajinomoto, February 14, 2001: EP1076094-A2 (5 worldwide citation)

A plasmid isolable from Corynebacterium thermoaminogenes, which comprises a gene coding for a Rep protein having the amino acid sequence shown in SEQ ID NO: 2 or an amino acid sequence having homology of 90% or more to the amino acid sequence shown in SEQ ID NO: 2, and has a size of about 4.4 kb or ...


8
Tsujimoto Nobuharu, Yasueda Hisashi, Kawahara Yoshio, Sugimoto Shinichi: Production of l-lysine. Ajinomoto Co, March 6, 2001: JP2001-057896 (3 worldwide citation)

PROBLEM TO BE SOLVED: To provide a method for producing L-lysine by a fermentation process using a vitamin B12 non-demanding thermophilic bacterium belonging to the genus Bacillus. SOLUTION: A methanol-assimilating thermophilic bacterium belonging to the genus Bacillus, capable of producing L-lysine ...


9
Hirano Seiko, Nonaka Gen, Matsuzaki Yumi, Akiyoshi Naoki, Nakamura Kanae, Kimura Eiichiro, Osumi Tsuyoshi, Matsui Kazuhiko, Kawahara Yoshio, Kurahashi Osamu, Nakamatsu Tsuyoshi, Sugimoto Shinichi: Thermophilic amino acid biosynthesis system enzyme gene of thermotolerant coryneform bacterium. Ajinomoto, July 3, 2002: EP1219712-A1 (2 worldwide citation)

A plurality of primer sets are designed based on a region where conservation at the amino acid level is observed among various microorganisms for known gene sequences corresponding to a gene coding for an enzyme of the L-amino acid biosynthetic pathway derived from Corynebacterium thermoaminogenes, ...


10
Kuwabara Yoko, Kimura Eiichiro, Kawahara Yoshio, Nakamatsu Tsuyoshi: Process for producing target substances by fermentation. Ajinomoto, January 26, 2000: EP0974647-A1 (2 worldwide citation)

An object resides in controlling the retaining and dissociation of a gene extrachromosomally for efficient production of an objective substance in a fermentative manner. By culturing and growing a microorganism containing a plasmid carrying a gene disadvantageously functioning for the production of ...



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