1
Kath John Charles, Luzzio Michael Joseph: Pyrimidine derivates for the treatment of abnormal cell growth. Pfizer Products, Kath John Charles, Luzzio Michael Joseph, LUMB J Trevor, July 8, 2004: WO/2004/056786 (148 worldwide citation)

The invention relates to compounds of the formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R2, R3, R4, R5, n, A and B are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compound ...


2
Kath John Charles, Tom Norma Jacqueline, Cox Eric David, Bhattacharya Samit Kumar: Heteroaromatic bicyclic derivatives useful as anticancer agents. Pfizer Prod, August 23, 2000: EP1029853-A1 (22 worldwide citation)

The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts and solvates thereof, wherein A, X, R, R and R are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula 1 and to phar ...


3
CHENG Hengmiao, JOHNSON JR Theodore Otto, KATH John Charles, LIU Kevin Kun Chin, LUNNEY Elizabeth Ann, NAGATA Asako, NAIR Sajiv Krishnan, PLANKEN Simon Paul, SUTTON Scott Channing: [fr] DÉRIVÉS DE PYRROLOPYRIMIDINE ET DE PURINE, [en] PYRROLOPYRIMIDINE AND PURINE DERIVATIVES. CHENG Hengmiao, JOHNSON JR Theodore Otto, KATH John Charles, LIU Kevin Kun Chin, LUNNEY Elizabeth Ann, NAGATA Asako, NAIR Sajiv Krishnan, PLANKEN Simon Paul, SUTTON Scott Channing, Pfizer, KLEIMAN Gabriel L, March 28, 2013: WO/2013/042006 (17 worldwide citation)

[en] The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Q, T, V, W, X, Y, Z, ring A, R1, R2, R3, R4, R5, R5a, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17 and m are defined herein. There novel pyrrolopyrimidine and purine derivat ...


4
Kath John Charles, Luzzio Michael Joseph: Pyrimidine derivatives for the treatment of abnormal cell growth. Pfizer Products, Kath John Charles, Luzzio Michael Joseph, FULLER Grover F, November 24, 2005: WO/2005/111024 (16 worldwide citation)

The present invention relates to a compound of the formula (1) wherein A and Ar are as defined herein. Such novel pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment o ...


5
Kath John Charles, Luzzio Michael Joseph: Pyrimidine derivatives for the treatment of abnormal cell growth. Pfizer Products, Kath John Charles, Luzzio Michael Joseph, LUMB J Trevor, July 8, 2004: WO/2004/056807 (11 worldwide citation)

The present invention relates to a compound of the formula (I), wherein R1-R4 are as defined herein. Such novel pyrimidine derivatives are useful in thetreatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of a ...


6
Brown Matthew Frank, Gaweco Anderson See, Gladue Ronald Paul, Kath John Charles, Poss Christopher Stanley: Heteroaryl-hexanoic acid amide derivatives as immunomodulatory agents. Pfizer Products, Brown Matthew Frank, Gaweco Anderson See, Gladue Ronald Paul, Kath John Charles, Poss Christopher Stanley, LUMB J Trevor, May 13, 2004: WO/2004/039787 (10 worldwide citation)

The present invention relates to compounds of the formula (I) wherein R1, R2, R3, R4, R5, R7, and L are as described in the specification. The present invention also relates to pharmaceutical compositions that include compounds of the formula (I) and a pharmaceutically acceptable carrier. Moreover, ...


7
Kath John Charles, Liu Zhengyu, Brown Maria Steflik, Winter Steven Mark, Truesdell Susan Jane, Szewc Ruby Anthea: 4-anilino quinazoline derivatives for the treatment of abnormal cell growth. Pfizer Products, Kath John Charles, Liu Zhengyu, Brown Maria Steflik, Winter Steven Mark, Truesdell Susan Jane, Szewc Ruby Anthea, LUMB J Trevor, July 1, 2004: WO/2004/054585 (9 worldwide citation)

The invention relates to compounds of the formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R2, R3 and R5 are as defined herein, and wherein the compound of formula (1) optionally further comprises a hydroxy substituent or an 0-glucuronic acid. The inve ...


8
Kath John Charles, Luzzio Michael Joseph, Lagreca Susan Deborah, Patel Nandini Chaturbhai: Pyrimidine derivatives for the treatment of abnormal cell growth. Pfizer Products, Kath John Charles, Luzzio Michael Joseph, Lagreca Susan Deborah, Patel Nandini Chaturbhai, FULLER Grover F Jr, June 7, 2007: WO/2007/063384 (7 worldwide citation)

The present invention relates to salts, solvates and substoichiometric solvates of N- [3-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4- pyrimidinyl]amino]methyl]-2-pyridinyl]-N-methylmethanesulfonamide. The invention also provides pharmaceutical compositions comprising such com ...


9
Henne Kirk Russell, Kath John Charles, Szewc Ruby Anthea: Benzoimidazole derivatives useful as antiproliferative agents. Pfizer Products, Henne Kirk Russell, Kath John Charles, Szewc Ruby Anthea, FULLER Grover F Jr, April 13, 2006: WO/2006/038111 (4 worldwide citation)

The invention relates to substantially pure compounds of the formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R, R1, R2, R3, R4, and R5 are as defined herein. The invention also relates to pharmaceutical compositions comprising the compounds of formula (1) ...


10
Kath John Charles, Luzzio Michael Joseph: Pyrimidines derivatives for the treatment of abnormal cell growth. Pfizer Products, Kath John Charles, Luzzio Michael Joseph, FULLER Grover F Jr, November 24, 2005: WO/2005/111022 (3 worldwide citation)

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof, wherein R1-R4 and Ar are as defined herein. Such novel pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This ...