1
Caroline Aciro, Victoria Alexandra Steadman, Simon Neil Pettit, Karine G Poullennec, Linos Lazarides, David Kenneth Dean, Neil Andrew Dunbar, Adrian John Highton, Andrew John Keats, Dustin Scott Siegel, Kapil Kumar Karki, Adam James Schrier, Petr Jansa, Richard Mackman, Jean Yves Chiva: Macrocyclic inhibitors of flaviviridae viruses. Gilead Sciences, Selcia, Francis O Ginah, September 29, 2015: US09145441 (3 worldwide citation)

Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.


2
Caroline Aciro, Victoria Alexandra Steadman, Simon Neil Pettit, Karine G Poullennec, Linos Lazarides, David Kenneth Dean, Neil Andrew Dunbar, Adrian John Highton, Andrew John Keats, Dustin Scott Siegel, Kapil Kumar Karki, Adam James Schrier, Petr Jansa, Richard Mackman: Macrocyclic inhibitors of flaviviridae viruses. Gilead Sciences, Selcia, Francis O Ginah, July 28, 2015: US09090653 (3 worldwide citation)

Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.


3
Amy Cagulada, Johann Chan, Lina Chan, Denise A Colby, Kapil Kumar Karki, Darryl Kato, Katie Ann Keaton, Sudha Kondapally, Chris Levins, Adam Littke, Ruben Martinez, Dominika Pcion, Troy Reynolds, Bruce Ross, Michael Sangi, Adam J Schrier, Pamela Seng, Dustin Siegel, Nathan Shapiro, Donald Tang, James G Taylor, Jonathan Tripp, Andrew W Waltman, Lawrence Yu: Synthesis of an antiviral compound. Gilead Sciences, September 13, 2016: US09440991 (1 worldwide citation)

The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.


4

5
Caroline Aciro, David Kenneth Dean, Neil Andrew Dunbar, Adrian John Highton, Petr Jansa, Kapil Kumar Karki, Andrew J Keats, Linos Lazarides, Richard L Mackman, Simon N Pettit, Karine G Poullennec, Adam James Schrier, Dustin Siegel, Victoria Alexandra Steadman: Macrocyclic inhibitors of flaviviridae viruses. Gilead Sciences, Cypralis, Sheppard Mullin Richter & Hampton, January 23, 2018: US09873716

Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.


6
Caroline Aciro, Jean Yves Chiva, David Kenneth Dean, Neil Andrew Dunbar, Adrian John Highton, Petr Jansa, Kapil Kumar Karki, Andrew John Keats, Linos Lazarides, Richard Mackman, Simon Neil Pettit, Karine G Poullennec, Adam James Schrier, Dustin Scott Siegel, Victoria Alexandra Steadman: Macrocyclic inhibitors of flaviviridae viruses. Gilead Sciences, Selcia, December 6, 2016: US09512175

Provided are compounds of Formula: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.


7
Amy Cagulada, Johann Chan, Lina Chan, Denise A Colby, Kapil Kumar Karki, Darryl Kato, Katie Ann Keaton, Sudha Kondappally, Chris Levins, Adam Littke, Ruben Martinez, Dominika Pcion, Troy Reynolds, Bruce Ross, Michael Sangi, Adam J Schrier, Pamela Seng, Dustin Siegel, Nathan Shapiro, Donald Tang, James G Taylor, Jonathan Tripp, Andrew W Waltman, Lawrence Yu: Synthesis of an antiviral compound. GILEAD SCIENCES, July 24, 2018: US10030033

The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.