1
Kanji Meguro, Takeshi Fujita: Thiazolidinedione derivatives, useful as antidiabetic agents. Takeda Chemical, Wenderoth Lind & Ponack, August 18, 1987: US04687777 (169 worldwide citation)

Thiazolidinedione derivatives of the formula: ##STR1## and pharmacologically acceptable salts thereof are novel compounds, which exhibit in mammals blood sugar- and lipid-lowering activity, and are of value as a therapeutic agent for treatment of diabetes and hyperlipemia.


2
Kanji Meguro, Takeshi Fujita: Thiazolidinedione derivatives, their production and use. Takeda Chemical, Wenderoth Lind & Ponack, February 16, 1988: US04725610 (79 worldwide citation)

Thiazolidinedione derivatives of the general formula: ##STR1## [wherein R.sup.1 is hydrogen or a hydrocarbon residue or heterocyclic residue which may each be substituted; R.sup.2 is hydrogen or lower alkyl which may be substituted by hydroxyl group; X is an oxygen or sulfur atom; Z is a hydroxylate ...


3
Kanji Meguro, Takeshi Fujita: Thiazolidine derivatives, their production and use. Takeda Chemical, Wenderoth Lind & Ponack, October 4, 1988: US04775687 (32 worldwide citation)

A thiazolidinedione derivative of the general formula: ##STR1## wherein X is an oxygen or sulfur atom, R.sup.1 and R.sup.2 each independently is hydrogen or a hydrocarbon residue which may optionally be substituted and R.sup.1 and R.sup.2 may jointly, together with the oxazole or thiazole ring, form ...


4
Kanji Meguro, Takeshi Fujita: 2,4-thiazolidinediones. Takeda Chemical, Wenderoth Lind & Ponack, April 15, 1986: US04582839 (19 worldwide citation)

Thiazolidinedione derivatives of the general formula: ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each represent hydrogen or a lower alkyl group; R.sup.3 is hydrogen or an acyl group; n is 0 or 1 and salts thereof are novel compounds, which exhibit in mammals blood sugar- and ...


5
Kanji Meguro, Kohei Nishikawa: 1,4-benzoxazine derivatives and pharmaceutical use. Takeda Chemical, Wenderoth Lind & Ponack, December 6, 1988: US04789675 (17 worldwide citation)

1,4-Benzoxazine derivatives representable by the general formula; ##STR1## wherein R.sup.1 and R.sup.2 independently stand for hydrogen, halogen atom, nitro group, an optionally substituted lower alkyl group, an optionally substituted amino group, an optionally substituted hydroxyl group, a lower al ...


6
Kanji Meguro, Takeshi Fujita, Chitoshi Hatanaka, Satoru Ooi: Method for producing thiazolidinedione derivatives. Takeda Chemical, Wenderoth Lind & Ponack, March 14, 1989: US04812570 (17 worldwide citation)

A compound of the formula: ##STR1## (wherein R.sup.1 is hydrogen or a lower alkyl) can be produced advantageously by (1) reacting a compound of the formula: ##STR2## (wherein R.sup.1 has a meaning given above) with a halogenating agent or sulfonyl halide to give a compound of the formula: ##STR3## ( ...


7
Kanji Meguro, Kohei Nishikawa: 1,4-benzothiazine derivatives, compositions containing them and method of use. Takeda Chemical, Wenderoth Lind & Ponack, February 3, 1987: US04640916 (9 worldwide citation)

1,4-Benzothiazine derivatives of the formula; ##STR1## wherein R.sup.1 and R.sup.2 independently stand for hydrogen, halogen, a lower alkyl group, a lower alkoxy group or trifluoromethyl group, or R.sup.1 and R.sup.2, taken together, form a 5-7 membered ring represented by ##STR2## wherein n is an i ...


8
Kanji Meguro, Takeshi Fujita: Oxazoleacetic acid derivatives. Takeda Chemical, Stiefel Gross Kurland & Pavane, July 22, 1986: US04602027 (8 worldwide citation)

A compound of the formula: ##STR1## wherein R.sup.1 is (A) a group of the formula, ##STR2## wherein R.sup.4 is H, a halogen or trifluoromethyl group, or (B) a group of the formula, ##STR3## wherein n is 0 or an integer of 1 to 3; R.sup.5 is H or an alkyl group of 1 to 6 carbon atoms; respective R.su ...


9
Kanji Meguro, Hitoshi Ikeda, Yujiro Yamamoto: Thiolactam-n-acetic acid derivatives. Takeda Chemical, Senju Pharmaceutical, Wenderoth Lind & Ponack, September 13, 1988: US04771050 (8 worldwide citation)

Compounds of the general formula: ##STR1## wherein, R.sup.1 and R.sup.2 are, the same or different, hydrogen, a halogen, a lower alkyl, a cycloalkyl, a lower alkoxy, trifluoromethyl or a phenylalkyloxy whose phenyl ring may be substituted by one to three substituents selected from the group consisti ...


10
Kanji Meguro, Akinobu Nagaoka: Substituted piperazinyl alkyl esters of 2-amino-4-aryl-1,4-dihydro-6-alkyl-3,5-pyridinedicarboxylates. Takeda Chemical, Wegner & Bretschneider, July 29, 1986: US04603135 (7 worldwide citation)

Dihydropyridine derivatives and acid addition salts thereof which are of use as prophylactic or/and therapeutic drugs for cardiovascular diseases, said dihydropyridine derivatives having the formula ##STR1## wherein R.sup.1 is a hydrogen atom or an aryl,