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Kandasamy Ramasamy, Robert Tam, Devron Averett: Monocyclic L-Nucleosides, analogs and uses thereof. ICN Pharmaceuticals, Robert D Fish, Fish & Associates, October 10, 2000: US06130326 (68 worldwide citation)

Novel monocyclic L-Nucleoside compounds have the general formula ##STR1## Embodiments of these compounds are contemplated to be useful in treating a wide variety of diseases including infections, infestations, neoplasms, and autoimmune diseases. Viewed in terms of mechanism, embodiments of the novel ...


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Guangyi Wang, Kandasamy Ramasamy, Wilfried E Seifert: Sugar modified nucleosides and oligonucleotides. ICN Pharmaceuticals, Crockett & Fish, October 28, 1997: US05681940 (50 worldwide citation)

A number of modified nucleosides are disclosed composed of modified sugar moieties which contain substituents at C1 and C4 positions, or branched substituents at C3 and C5 positions of deoxyribose or ribose. Each nucleoside is converted to or properly protected and then converted to the correspondin ...


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Phillip Dan Cook, David J Ecker, Charles John Guinosso, Oscar Leobardo Acevedo, Andrew Kawasaki, Kandasamy Ramasamy: Compound for detecting and modulating RNA activity and gene expression. Isis Pharmaceuticals, Woodcock Washburn Kurtz Mackiewicz & Norris, July 17, 2001: US06262241 (38 worldwide citation)

Compositions and methods for modulating the activity of RNA and DNA are disclosed. In accordance with preferred embodiments, antisense compositions are prepared comprising targeting and reactive portions. Reactive portions which act, alternatively, through phosphorodiester bond cleavage, through bac ...


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Kandasamy Ramasamy, Wilfried E Seifert: Oligonucleotide analogs with an amino acid or a modified amino alcohol residue. ICN Pharmaceuticals, Robert D Fish, Crockett & Fish, October 19, 1999: US05969135 (12 worldwide citation)

The present invention provides various novel oligonucleotide analogs having one or more properties that make the subject compounds superior to conventional oligonucleotides for use in procedures employing oligonucleotides. The compounds of the invention are oligonucleotide analogs in which the furan ...


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Robert Tam, Guangyi Wang, Devron Averett, Kandasamy Ramasamy: Cytokine related treatments of disease. Ribapharm, Robert D Fish, Rutan & Tucker, July 23, 2002: US06423695 (10 worldwide citation)

Nucleosides and other compounds to selectively modulate Th1 and Th2 responses relative to each other in the treatment of disease. In one aspect of the invention, administration of a nucleoside or other compound reduces the dosage at which a primary drug is administered. In another aspect of the inve ...


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Kandasamy Ramasamy, Arthur F Lewis, Roland K Robins deceased, Natarajan Raju, Ramesh Bharadwaj, Vjera Pejanovic: Procedures for obtaining ribo-C-nucleosides. ICN Pharmaceuticals, Robert D Crockett & Fish Fish, May 25, 1999: US05907036 (2 worldwide citation)

Novel procedures for obtaining ribo-C-nucleosides, including especially 2-.beta.-D-ribofuranosylthiazole-4-carboxylamide (tiazofirin) and 2-.beta.-D-ribofuranosylselenazole-4-carboxylamide (sylenazofurin) and synthesis intermediates thereof. The novel procedures involve introducing a cyano group at ...


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Robert Tam, Kandasamy Ramasamy, Zhi Hong, Johnson Lau: Nucleoside analogs with carboxamidine modified monocyclic base. Valeant Pharmaceuticals North America, McDermott Will & Emery, December 29, 2009: US07638496

Novel nucleoside analog compounds are disclosed. The novel compounds or pharmaceutically acceptable esters or salts thereof may be used in pharmaceutical compositions, and such compositions may be used to treat an infection, an infestation, a neoplasm, or an autoimmune disease. The novel compounds m ...


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Colin Granger, Robert Orr, Kandasamy Ramasamy: Multivalent salts of pyridostigmine and related compounds. ICN Pharmaceuticals, Robert D Fish, Fish & Associates, April 3, 2001: US06211201

A quaternary ammonium cholinergic agent is complexed with a multivalent anion, or with multiple monovalent anions. The complex may be administered orally to a patient to treat pain, or for some other purpose. Numerous modifications are contemplated, including modifications to the ring structure of t ...