1
Kalyan Handique, Bishnu Gogoi, Mark A Burns, Carlos H Mastrangelo: Moving microdroplets. The Regents of the University of Michigan, Medlen & Carroll, October 10, 2000: US06130098 (336 worldwide citation)

The movement and mixing of microdroplets through microchannels is described employing microscale devices, comprising microdroplet transport channels, reaction regions, electrophoresis modules, and radiation detectors. The discrete droplets are differentially heated and propelled through etched chann ...


2
Kalyan Handique, Karthik Ganesan, Sundaresh N Brahmasandra: Methods and systems for control of microfluidic devices. HandyLab, Fish & Richardson P C, March 7, 2006: US07010391 (127 worldwide citation)

The present invention provides control methods, control systems, and control software for microfluidic devices that operate by moving discrete micro-droplets through a sequence of determined configurations. Such microfluidic devices are preferably constructed in a hierarchical and modular fashion wh ...


3
Betty Wu, Karthik Ganesan, Kalyan Handique, Gene Parunak: Methods and systems for releasing intracellular material from cells within microfluidic samples of fluids. HandyLab, Fish & Richardson P C, March 20, 2007: US07192557 (115 worldwide citation)

The present invention relates to a microfluidic system for processing a cell-containing liquid. The system includes a lysing zone to receive the cell-containing sample and a positioning element to position the cell-containing sample in a lysing position in the vicinity of a lysing mechanism. The lys ...


4
Gene Parunak, Kalyan Handique, Betty Wu, Aaron Kehrer: Methods and systems for processing microfluidic samples of particle containing fluids. HandyLab, Fish & Richardson P C, September 18, 2007: US07270786 (109 worldwide citation)

The present invention relates to a microfluidic system for processing a cell-containing liquid. The system includes a microfabricated substrate having an enrichment channel to prepare an enriched cell sample from the cell-containing liquid. A flow through member is in liquid communication with the e ...


5
Kalyan Handique: Heat-reduction methods and systems related to microfluidic devices. HandyLab, Pennie & Edmonds, February 17, 2004: US06692700 (107 worldwide citation)

A system and method for preventing or reducing unwanted heat in a microfluidic of the device while generating heat in selected regions of the device.


6
Jeff Williams, Kalyan Handique, Kerry Wilson: Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples. HandyLab, Knobbe Martens Olson & Bear, March 13, 2012: US08133671 (105 worldwide citation)

The technology described herein generally relates to systems for extracting polynucleotides from multiple samples, particularly from biological samples, and additionally to systems that subsequently amplify and detect the extracted polynucleotides. The technology more particularly relates to microfl ...


7
Kalyan Handique, Gene Parunak: Moving microdroplets in a microfluidic device. HandyLab, Fish & Richardson P C, January 29, 2008: US07323140 (84 worldwide citation)

The present invention relates to a system and method for moving samples, such as fluid, within a microfluidic system using a plurality of gas actuators for applying pressure at different locations within the microfluidic. The system includes a substrate which forms a fluid network through which flui ...


8
Kalyan Handique, Bishnu Gogoi, Mark A Burns: Moving microdroplets. The Regents of the University of Michigan, Medlen & Carroll, June 28, 2005: US06911183 (75 worldwide citation)

The movement and mixing of microdroplets through microchannels is described employing microscale devices, comprising microdroplet transport channels, reaction regions, electrophoresis modules, and radiation detectors. The discrete droplets are differentially heated and propelled through etched chann ...


9
Kalyan Handique, Sundaresh N Brahmasandra, Karthik Ganesan, Jeff Williams: Microfluidic system for amplifying and detecting polynucleotides in parallel. HandyLab, Knobbe Martens Olson & Bear, August 16, 2011: US07998708 (74 worldwide citation)

The present technology provides for an apparatus for detecting polynucleotides in samples, particularly from biological samples. The technology more particularly relates to microfluidic systems that carry out PCR on nucleotides of interest within microfluidic channels, and detect those nucleotides. ...


10
Kalyan Handique, Mark A Burns: Compositions and methods for liquid metering in microchannels. The Reagents of The University of Michigan, Medlen & Carroll, February 28, 2006: US07004184 (74 worldwide citation)

The movement and mixing of microdroplets through microchannels is described employing microscale devices, comprising microdroplet transport channels, reaction regions, electrophoresis modules, and radiation detectors. Microdroplets are metered into defined volumes and are subsequently incorporated i ...