21
Alexey Popov, Elizabeth Enlow, James Bourassa, Colin R Gardner, Hongming Chen, Laura M Ensign, Samuel K Lai, Tao Yu, Justin Hanes, Ming Yang: Nanocrystals, compositions, and methods that aid particle transport in mucus. Kala Pharmaceuticals, K & L Gates, Louis C Culman, Michelle Glasky Bergman, July 19, 2016: US09393212

Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may in ...


22
Alexey Popov, Elizabeth Enlow, James Bourassa, Colin R Gardner, Hongming Chen, Laura M Ensign, Samuel K Lai, Tao Yu, Justin Hanes, Ming Yang: Nanocrystals, compositions, and methods that aid particle transport in mucus. Kala Pharmaceuticals, K&L Gates, Louis C Cullman, Michelle Glasky Bergman, July 19, 2016: US09393213

Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may in ...


23
Fabiana Kimie Kashiwabuchi, Justin Hanes, Hai Quan Mao, Peter John McDonnell, Qingguo Xu, Shuming Zhang: Drug loaded microfiber sutures for ophthalmic application. The Johns Hopkins University, Pabst Patent Group, January 3, 2017: US09533068

Ophthalmic suture materials made from biocompatible and biodegradable polymers with high tensile strength for use in drug delivery, methods of making them, and method of using them for ocular surgery and repair have been developed. The suture materials are made from a combination of a biodegradable, ...


24
Laura Ensign, Richard Cone, Justin Hanes: Nanoparticle formulations with enhanced mucosal penetration. The Johns Hopkins University, Pabst Patent Group, April 25, 2017: US09629813

Hypotonic formulations were evaluated for delivering water-soluble drugs and for drug delivery with muco-inert (that is, non-adhesive) mucus-penetrating nanoparticles (MPP). Hypotonic formulations markedly increased the rate at which drugs and MPP reached the epithelial surface, including deep into ...


25
Justin Hanes, David A Edwards, Carmen Evora, Robert Langer: Particles incorporating surfactants for pulmonary drug delivery. Massachusetts Institute of Technology, Hamilton Brook Smith & Reynolds P C, February 13, 2001: USRE037053

Improved aerodynamically light particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of a biodegradable material and have a tap density less than 0.4 g/cm


26
David A Edwards, Giovanni Caponetti, Jeffrey S Hrkach, Noah Lotan, Justin Hanes, Robert S Langer, Abdellaziz Ben Jebria: Porous particles for deep lung delivery. The Penn Research Foundation, Anabela Cristina Taylor Esq, Hamilton Brook Smith & Reynolds PC, October 25, 2001: US20010033828-A1

Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a biodegradable material and have a mass density less than 0.4 g/cm3/. The particles may be formed of biod ...


27
David A Edwards, Giovanni Caponetti, Jeffrey S Hrkach, Noah Lotan, Justin Hanes, Robert S Langer, Abdellaziz Ben Jebria: Porous particles for deep lung delivery. The Penn Research Foundation, Anabela Cristina Taylor Esq, Hamilton Brook Smith & Reynolds PC, October 25, 2001: US20010033829-A1

Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a biodegradable material and have a mass density less than 0.4 g/cm3/. The particles may be formed of biod ...


28
David A Edwards, Giovanni Caponetti, Jeffrey S Hrkach, Noah Lotan, Justin Hanes, Robert S Langer, Abdellaziz Ben Jebria: Porous particles for deep lung delivery. The Penn Research Foundation, Anabela Cristina Taylor Esq, Hamilton Brook Smith & Reynolds PC, October 25, 2001: US20010033830-A1

Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a biodegradable material and have a mass density less than 0.4 g/cm3/. The particles may be formed of biod ...


29
David A Edwards, Giovanni Caponetti, Jeffrey S Hrkach, Noah Lotan, Justin Hanes, Robert S Langer, Abdellaziz Ben Jebria: Porous particles comprising excipients for deep lung delivery. Massachusetts Institute of Technology, The Penn State Research Foundation, Elmore Craig PC, September 30, 2004: US20040191186-A1

Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a biodegradable material and have a mass density less than 0.4 g/cm3/. The particles may be formed of biod ...


30
David A Edwards, Giovanni Caponetti, Jeffrey S Hrkach, Noah Lotan, Justin Hanes, Abdellaziz Ben Jebria, Robert S Langer: Aerodynamically light particles for pulmonary drug delivery. The Penn State Research Foundation, Massachusetts Institute of Technology, Carolyn S Elmore Esq, Elmore Craig PC, March 11, 2004: US20040047811-A1

Improved aerodynamically light particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of biodegradable material and have a tap density of less than 0.4 g/cm3 and a m ...