1
Werner Rogalski, Richard Kirchlechner, Jurgen Seubert, Rudolf Gottschlich, Rosmarie Steinigeweg, Rolf Bergmann, Helmut Wahlig, Joachim Gante: Tetracyclic compounds. Merck Patent Gesellschaft mit beschrankter Haftung, Millen & White, May 17, 1977: US04024272 (104 worldwide citation)

Tetracyclic compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each are H or alkyl, R.sup.5 is H, F, Cl, Br, CF.sub.3, OH, alkyl, alkoxy, NO.sub.2, NH.sub.2, alkylamino, dialkylamino or acylamino and X is O, S, SO, SO.sub.2, NH, N-alkyl or N-acyl, alkyl and alkoxy in eac ...


2
Klaus Bofinger, Hans A Kurmeier, Michael Romer, Jurgen Seubert: Process for outgassing liquid-crystalline materials. Merck Patent Gesellschaft mit beschrankter Haftung, Millen & White, October 13, 1987: US04699636 (21 worldwide citation)

Liquid-crystalline materials can be outgassed by thermal treatment under reduced pressure in a thin-layer evaporator or with additional ultrasonic treatment.


3
Jurgen Seubert, Herbert Thomas, Peter Andrews: 2-Acyl-4-oxo-pyrazino-isoquinoline derivatives and process for the preparation thereof. Merck Patent Gesellschaft mit beschrankter Haftung, Millen Raptes & White, January 4, 1977: US04001411 (15 worldwide citation)

2-Acyl-4-oxo-hexahydro-4H-pyrazino[2,1-a]isoquinoline derivatives of the formula ##STR1## wherein COR is the acyl radical of an up to 26 carbon atom acid and their physiologically acceptable acid addition and quaternary ammonium salts, are anthelmintics and can be produced by reacting 4-oxo-1,2,3,6, ...


4
Jurgen Seubert, Rolf Pohlke, Herbert Thomas, Peter Andrews: Ring substituted pyrazino-isoquinoline derivatives and their preparation. Merck Patent Gesellschaft mit Beschrankter Haftung, Millen & White, July 24, 1979: US04162319 (6 worldwide citation)

Isoquinolines of the formula ##STR1## wherein R.sup.1 is H, OH, alkyl; R.sup.2 is H, or an unsubstituted or substituted carbonyl, carbonyloxy or thiocarbonyl group; R.sup.3 is H, alkyl or hydroxy alkyl; R.sup.4 is H, alkyl or phenyl; R.sup.5 is O, H,H or H and alkyl, phenyl, halo or hydroxy; R.sup.6 ...


5
Jurgen Seubert, Rolf Pohlke, Herbert Thomas, Peter Andrews: Ring substituted pyrazino-isoquinoline derivatives and their preparation. Merck Patent Gesellschaft mit beschrankter Haftung, Millen & White, September 27, 1977: US04051243 (6 worldwide citation)

Isoquinolines of the formula ##STR1## wherein R.sup.1 is H, OH, alkyl; R.sup.2 is H, or an unsubstituted or substituted carbonyl, carbonyloxy or thiocarbonyl group; R.sup.3 is H, alkyl or hydroxy alkyl; R.sup.4 is H, alkyl or phenyl; R.sup.5 is O, H,H or H and alkyl, phenyl, halo or hydroxy; R.sup.6 ...


6
Eike Poetsch, Volker Meyer, Ulrich Heywang, Rainer Christ, Jurgen Seubert: Process for the preparation of cinnamic acid derivatives. Merck Patent Gesellschaft mit Beschrankter Haftung, Millen White Zelano & Branigan P C, October 6, 1998: US05817862 (5 worldwide citation)

The invention relates to a process for the preparation of cinnamic acid derivatives which involves reacting chlorinated aromatic compounds and acrylic acid derivatives in the presence of palladium catalysts.


7
Jurgen Seubert, Herbert Thomas, Peter Andrews: 2-Acyl-4-oxo-pyrazino-isoquinoline derivatives and process for the preparation thereof. Merck Patent Gesellschaft mit beschraenkter Haftung, Millen & White, April 1, 1980: US04196291 (4 worldwide citation)

2-Acyl-4-oxo-hexahydro-4H-pyrazino[2,1-a]isoquinoline derivatives of the formula ##STR1## wherein COR is the acyl radical of an up to 26 carbon atom acid and their physiologically acceptable acid addition and quaternary ammonium salts, are anthelmintics and can be produced by reacting 4-oxo-1,2,3,6, ...


8
Jurgen Seubert, Herbert Thomas, Peter Andrews: 2-Acyl-4-oxo-pyrazino-isoquinoline derivatives and process for the preparation thereof. Merck Patent Gesellschaft mit Beschrankter Haftung, Millen & White, September 12, 1978: US04113867 (4 worldwide citation)

2-Acyl-4-oxo-hexahydro-4H-pyrazino[2,1-a]isoquinoline derivatives of the formula ##STR1## wherein COR is the acyl radical of an up to 26 carbon atom acid and their physiologically acceptable acid addition and quaternary ammonium salts, are anthelmintics and can be produced by reacting 4-oxo-1,2,3,6, ...


9
Jurgen Seubert, Herbert Thomas, Peter Andrews: 2-Acyl-4-oxo-pyrazino-isoquinoline derivatives and process for the preparation thereof. Merck Patent Gesellschaft mit beschrankter Haftung, Millen & White, February 27, 1979: US04141978 (3 worldwide citation)

2-Acyl-4-oxo-hexahydro-4H-pyrazino[2,1-a]isoquinoline derivatives of the formula ##STR1## wherein COR is the acyl radical of an up to 26 carbon atom acid and their physiologically acceptable acid addition and quaternary ammonium salts, are anthelmintics and can be produced by reacting 4-oxo-1,2,3,6, ...


10
Bernard Riefling, Jurgen Seubert, Volker Reiffenrath, Reinhard Hittich: Process for the reaction of halogenated aromatics with electrophiles. Merck Patent Gesellschaft mit beschrankter Haftung, Millen White Zelano & Branigan, November 16, 1993: US05262556 (3 worldwide citation)

The invention relates to a process for the reaction of fluorinated or chlorinated aromatics with electrophiles at the ortho position relative to the fluorine or chlorine atom, characterized in that a strong base is added to a mixture of the fluorinated or chlorinated aromatic and the electrophile.