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Yasuhiro Funahashi, Akihiko Tsuruoka, Masayuki Matsukura, Toru Haneda, Yoshio Fukuda, Junichi Kamata, Keiko Takahashi, Tomohiro Matsushima, Kazuki Miyazaki, Ken ichi Nomoto, Tatsuo Watanabe, Hiroshi Obaishi, Atsumi Yamaguchi, Sachi Suzuki, Katsuji Nakamura, Fusayo Mimura, Yuji Yamamoto, Junji Matsui, Kenji Matsui, Takako Yoshiba, Yasuyuki Suzuki, Itaru Arimoto: Nitrogen-containing aromatic derivatives. Eisai, Andrea L C Robidoux, Choate Hall & Stewart, August 7, 2007: US07253286 (78 worldwide citation)

Compounds represented by the following general formula: [wherein Ag is an optionally substituted 5- to 14-membered heterocyclic group, etc.; Xg is —O—, —S—, etc.; Yg is an optionally substituted C6-14 aryl group, an optionally substituted 5- to 14-membered heterocyclic group, etc.; and Tg1 is a grou ...


2
Yasuhiro Funahashi, Akihiko Tsuruoka, Masayuki Matsukura, Toru Haneda, Yoshio Fukuda, Junichi Kamata, Keiko Takahashi, Tomohiro Matsushima, Kazuki Miyazaki, Ken ichi Nomoto, Tatsuo Watanabe, Hiroshi Obaishi, Atsumi Yamaguchi, Sachi Suzuki, Katsuji Nakamura, Fusayo Mimura, Yuji Yamamoto, Junji Matsui: Nitrogen-containing aromatic derivatives. Eisai R & D Management, Andrea L C Robidoux, Choate Hall & Stewart, November 3, 2009: US07612092 (25 worldwide citation)

Compounds represented by the following general formula: [wherein Ag is an optionally substituted 5- to 14-membered heterocyclic group, etc.; Xg is —O—, —S—, etc.; Yg is an optionally substituted C6-14 aryl group, an optionally substituted 5- to 14-membered heterocyclic group, etc.; and Tg1 is a grou ...


3
Yasuhiro Funahashi, Masayuki Matsukura, Tatsuo Watanabe, Hiroshi Obaishi, Junji Matsui: Nitrogen-containing aromatic derivatives. Eisai R&D Management, Birch Stewart Kolasch & Birch, February 12, 2013: US08372981 (13 worldwide citation)

Compounds represented by the following general formula: wherein Ag is an optionally substituted 5- to 14-membered heterocyclic group, etc.; Xg is —O—, —S—, etc.; Yg is an optionally substituted C6-14 aryl group, an optionally substituted 5- to 14-membered heterocyclic group, etc.; and Tg1 is a group ...


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Yasuhiro Funahashi, Toru Haneda, Junichi Kamata, Tatsuo Watanabe, Hiroshi Obaishi, Junji Matsui: Nitrogen-containing aromatic derivatives. Eisai R&D Management, Birch Stewart Kolasch & Birch, July 5, 2011: US07973160 (13 worldwide citation)

Compounds represented by the following general formula: [wherein Ag is an optionally substituted 5- to 14-membered heterocyclic group, etc.; Xg is —O—, —S—, etc.; Yg is an optionally substituted C6-14 aryl group, an optionally substituted 5- to 14-membered heterocyclic group, etc.; and Tg1 is a grou ...


5
Hideo Yoshihara, Mikiho Kiuchi, Satoshi Nakayama, Toa Hayasaka, Junji Matsui: Soft x-ray source and method for manufacturing the same. Nippon Electric, Hopgood Calimafde Kalil Blaustein & Lieberman, December 9, 1980: US04238706 (11 worldwide citation)

There is disclosed a soft x-ray source comprising (a) a substrate formed of a thermally conductive material, such as copper or a copper alloy, which tends to generate predominantly hard x-rays upon the collision of an electron beam, (b) an intermediate layer formed on the substrate, the intermediate ...


6
Junji Matsui, Naoki Tarui, Yu Momose, Ken ichi Naruo: Apoptosis inhibitor. Takeda Chemical, Philippe Y Riesen, Miriam Sohn, July 11, 2000: US06087384 (7 worldwide citation)

An apoptosis inhibitor which comprises a compound of the formula: wherein R represents a hydrocarbon group that may be substituted or a heterocyclic group that may be substituted; Y represents a group of the formula: --CO--, --CH(OH)-- or --NR.sup.3 -- where R.sup.3 represents an alkyl group that ma ...


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Naoyuki Kanzaki, Tomohiro Kawamoto, Junji Matsui, Kazuo Nakahama, Ohji Ifuku: Microorganism resistant to threonine analogue and production of biotin. Takeda Chemical, Shiseido Company, Wenderoth Lind & Ponack L, September 4, 2001: US06284500 (2 worldwide citation)

A microorganism resistant to a threonine analogue, which has a plasmid containing part or whole of a biotin operon; and a process for producing biotin, which comprises culturing a microorganism described above in a medium to produce and accumulate biotin in the medium, and collecting biotin.


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Yusuke Narita, Junji Matsui, Yasuhiro Funahashi: Therapeutic agent for tumor. Eisai R&D Management, Fish & Richardson P C, February 24, 2015: US08962650 (1 worldwide citation)

A therapeutic agent for tumor for combined use of a compound or pharmaceutically acceptable salt thereof represented by Formula (I) and a compound represented by Formula (II): wherein R1 is C1-6 alkyl or C3-8 cycloalkyl, R2 is a hydrogen atom or C1-6 alkoxy, and R3 is a hydrogen atom or a halogen at ...


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Junji Matsui, Yuji Yamamoto, Toshimitsu Uenaka: Method for assay on the effect of vascularization inhibitor. Eisai R&D Management, Fish & Richardson P C, March 3, 2015: US08969344 (1 worldwide citation)

The present invention provides a method of predicting the antitumor effect of an angiogenesis inhibitor. It is possible to predict the antitumor effect of an angiogenesis inhibitor by evaluating the EOF dependency of a tumor cell for proliferation and/or survival and using the EGF dependency as an i ...