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Josef Bencsik, James F Blake, James M Graham, Martin F Hentemann, Nicholas C Kallan, Ian S Mitchell, Stephen T Schlachter, Keith L Spencer, Dengming Xiao, Rui Xu, Mike Welch, Jun Liang, Brian S Safina: Pyrimidyl cyclopentanes as AKT protein kinase inhibitors. ARRAY BIOPHARMA, Genentech, Viksnins Harris & Padys PLLP, August 9, 2016: US09409886

The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for ...


42
Toby Jonathan Blench, Charles Ellwood, Simon Charles Goodacre, Yingjie Lai, Jun Liang, Calum Macleod, Steven R Magnuson, Vickie H Tsui, Karen Williams, Birong Zhang: Azabenzothiazole compounds, compositions and methods of use. F Hoffmann La Roche, Tamara Kale, Genentech, April 15, 2014: US08697708

Provided are compounds of Formula I, stereoisomers, tautomers, solvates, prodrugs and pharmaceutically acceptable salts thereof, wherein A, X, R1, R2, R4 and R5 are defined herein, a pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant ...


43
Bing Yan Zhu, Michael Siu, Steven R Magnuson, Richard Pastor, He Haiying, Xiao Yisong, Zheng Jifu, Xu Xing, Zhao Junping, Christopher Hurley, Jun Liang, Wendy Liu, Joseph P Lyssikatos: Triazolopyridine JAK inhibitor compounds and methods. Genentech, Tamara A Kale, September 6, 2016: US09434732

A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are defined herein, are useful as JAK kinase inhibitors. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable car ...


44
Brian K Albrecht, Steven F Bellon, Victor S Gehling, Jean Christophe Harmange, Kwong Wah Lai, Jun Liang, Peter Dragovich, Daniel F Ortwine, Sharada Labadie, Birong Zhang, James Richard Kiefer: Pyrazolo compounds and uses thereof. Genentech, CONSTELLATION PHARMACEUTICALS, Viksnins Harris Padys Malen, July 31, 2018: US10035801

Provided are compounds useful as inhibitors of one or more histone demethylases, such as KDM5. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using the present composition in the treatment of various disorders.


45
Anna Leivers, Josef R Bencsik, James F Blake, Martin F Hentemann, Nicholas C Kallan, Jun Liang, Ian S Mitchell, Stephen T Schlachter, Eli M Wallace, Rui Xu, Tony P Tang: 5H-cyclopenta[d]pyrimidines as AKT protein kinase inhibitors. Genentech, ARRAY BIOPHARMA, Viksnins Harris & Padys PLLP, May 3, 2016: US09328091

Compounds of Formula I are useful for inhibiting AKT protein kinases. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pat ...


46
Che Yu Chou, Qun Huang, Tai Shan Zhu, Wen Chih Lan, Tao Jiang, Hai Qian Ge, Jun Liang Zhang, Wei Wei Yu, Hua Yong Wang, Ji Bing Guo, Zhou Chen, Zhi Jun Shi: Electronic device. Fu Tai Hua, Hon Hai Precision, Novak Druce Connolly Bove Quigg, December 9, 2014: US08908370

An electronic device includes a body, a cover coupled to the body, and a sliding mechanism. The sliding mechanism includes a rotating component, a first locking component, and a second locking component. When the second locking component moves to a locked position, the second locking component engag ...


47
Wei Cheng Ku, Jun Liang Lai: Probe card of low power loss. MPI CORPORATION, Ming Chow, Sinorica, April 19, 2016: US09316685

A probe card, which is used to transmit power signals and test signals from a tester to a DUT, includes a pin base, a plurality of signal pins, a signal conducting circuit and at least one power conducting circuit. The signal pins are made of conductive materials, and each contacts the DUT with an e ...


48

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Ya Chih Hsiao, Jun Liang Lu: Electronic device and method for adjusting setting for projecting screen by re-calculating ambient contrast ratio according to variation of ambient light. Acer Incorporated, Jianq Chyun IP Office, September 19, 2017: US09769441

An electronic device including a projection unit, an ambient light sensor and a processing unit is provided. The projection unit has a projection lens fixed on a side surface of the electronic device. The ambient light sensor is fixed on the side surface of the electronic device. The processing unit ...


50
Toby Blench, Simon Goodacre, Yingjie Lai, Jun Liang, Calum Macleod, Steven Magnuson, Vickie Tsui, Karen Williams, Birong Zhang: Pyrazolopyridine compounds, compositions and methods of use. Genentech, Tamara A Kale, April 12, 2016: US09309240

The invention provides compounds of Formula I, stereoisomers or pharmaceutically acceptable salts thereof, wherein A, X, R1, R2, R4 and R5 are defined herein, a pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and method ...



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