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Mark T Bilodeau, Nicholas D P Cosford, John C Hartnett, Yiwei Li, Jun Liang, Peter J Manley, Lou Anne Neilson, Tony Siu, Zhicai Wu: Inhibitors of Akt activity. Merck & Co, Matthew A Leff, David A Muthard, June 9, 2009: US07544677 (5 worldwide citation)

The present invention is directed to compounds which contain substituted 5-deazapteridine moieties which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treat ...


12
Ai Qun Liu, Xiao Jun Liang, Xu Ming Zhang, Yi Sun: Cell analysis using laser with external cavity. Nanyang Technological University, Birch Stewart Kolasch & Birch, August 3, 2010: US07767444 (5 worldwide citation)

An apparatus and method for analyzing biological cells and other particles using an external laser cavity. Microfluidic channels contain and transport biological cells to be analyzed. A laser diode provides light for cell analysis. An external cavity is provided between one surface of the laser diod ...


13
Jun Liang Hu: Clamping structure and heat dissipating module using same. Molex Incorporated, Stephen Z Weiss, May 9, 2006: US07042728 (5 worldwide citation)

A clamping structure is used to fix a heat-dissipating body on a chip module. The clamping structure comprises a clamping body, two clamping portions, a pivot element, a top frame and a bottom frame. The two clamping portions are respectively connected to two sides of the clamping body and are clamp ...


14
Jun Liang Kuo: Mechanical writing apparatus with a mechanism for retracting presharpened pencil lead elements. Jun Lian Kuo, Bacon & Thomas, June 22, 1993: US05221151 (5 worldwide citation)

A writing apparatus with retractable presharpened pencil lead elements is disclosed having an outer pen holder, an inner cylinder slidably mounted within the outer pen holder, a compression spring to bias the inner cylinder toward an end of the outer pen holder, a pencil lead pushing mechanism to pu ...


15
Josef R Bencsik, James F Blake, Nicholas C Kallan, Ian S Mitchell, Keith L Spencer, Dengming Xiao, Rui Xu, Christine Chabot, Jun Liang, Brian S Safina: Pyrimidyl cyclopentanes as AKT protein kinase inhibitors. Array BioPharma, Genentech, Viksnins Harris & Padys PLLP, February 19, 2013: US08377937 (4 worldwide citation)

The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for ...


16
Anna L Banka, Josef R Bencsik, James Blake, Martin Hentemann, Nicholas C Kallan, Jun Liang, Ian S Mitchell, Stephen T Schlachter, Eli M Wallace, Rui Xu, Tony P Tang: 5H-cyclopenta[D]pyrimidines as AKT protein kinase inhibitors. Genentech, Array BioPharma, Viksnins Harris & Padys PLLP, December 11, 2012: US08329709 (4 worldwide citation)

Compounds of Formula I are useful for inhibiting AKT protein kinases. Methods using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathol ...


17
Nicholas D P Cosford, Mark E Layton, Jun Liang, Craig W Lindsley, Philip E Sanderson, Zhijian Zhao: Inhibitors of Akt activity. Merck & Co, Matthew A Leff, David A Muthard, September 15, 2009: US07589068 (4 worldwide citation)

The instant invention provides for compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering ...


18
Simon Charles Goodacre, Yingjie Lai, Jun Liang, Steven R Magnuson, Kirk D Robarge, Mark S Stanley, Vickie Hsiao Wei Tsui, Karen Williams, Birong Zhang, Aihe Zhou: Janus kinase inhibitor compounds and methods. F Hoffmann La Roche, Tamara Kale, Genentech, July 16, 2013: US08486950 (3 worldwide citation)

The invention provides compounds of Formula I, stereoisomers or pharmaceutically acceptable salts thereof, wherein A, B, D, R1, R2, R4 and R5 are defined herein, a pharmaceutical composition that includes a compound of Formula I and methods of use thereof.


19
Russell Laporte, Daniel Collins, Ankita Pawar, Jun Liang: Authoring a virtualized data center. EMC Corporation, Proskauer Rose, November 3, 2015: US09176648 (3 worldwide citation)

Described are methods, systems, and apparatus, including computer program products for authoring a virtual representation of a data center. An identity of a first IT component is determined. First position data indicating a position of the first IT component in the data center is received. The assoc ...


20
Josef Bencsik, James F Blake, James M Graham, Martin F Hentemann, Nicholas C Kallan, Ian S Mitchell, Stephen T Schlachter, Keith L Spencer, Dengming Xiao, Rui Xu, Mike Welch, Jun Liang, Brian S Safina: Pyrimidyl cyclopentanes as AKT protein kinase inhibitors. Array Biopharma, Genentech, Viksnins Harris & Padys PLLP, December 31, 2013: US08618097 (2 worldwide citation)

The present invention provides compounds of Formula (I), including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and fo ...



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