1
Harold D Doshan, Julio Perez: Synthesis of R-N-methylnaltrexone. Progenics Pharmaceuticals, Wolf Greenfield & Sacks P C, March 9, 2010: US07674904 (25 worldwide citation)

This invention relates to stereoselective synthesis of R-MNTX and intermediates thereof, pharmaceutical preparations comprising R-MNTX or intermediates thereof and methods for their use.


2
Richard A Freese, Julio Perez: Rapid response attitude control logic for shaft-driven lift fan STOVL engine. United Technologies Corporation, August 7, 2001: US06270037 (7 worldwide citation)

A short take-off and vertical landing (“STOVL”) aircraft has a conventional gas turbine engine that is selectively mechanically connected to a vertically-oriented lift fan by a drive shaft when the aircraft operates in a vertical flight mode. An engine control provides for rapid response attitude co ...


3
Harold D Doshan, Julio Perez: -methylnaltrexone, Synthesis of. Progenics Pharmaceuticals, McCarter & English, Jonathan M Sparks, Maneesh Gulati Esq, January 1, 2013: US08343992 (4 worldwide citation)

This invention relates to stereoselective synthesis of R-MNTX and intermediates thereof, pharmaceutical preparations comprising R-MNTX or intermediates thereof and methods for their use.


4
Alfred A Avey, Julio Perez: Preparation and use of (R),(R)-2,2′-bis-methylnaltrexone. Progenics Pharmaceuticals, McCarter & English, Jonathan M Sparks, Maneesh Gulati, June 25, 2013: US08471022 (3 worldwide citation)

This invention relates to the synthesis of (R),(R)-2,2′-bis-MNTX, as shown in Formula (I), and related methods and products.


5
Alfred A Avey, Appavu Chandrasekaren, Harold D Doshan, Julio Perez, Yakov Rotshteyn: Peripheral opioid receptor antagonists and uses thereof. Progenics Pharmaceuticals, Wyeth, McCarter & English, Jonathan M Sparks, Maneesh Gulati Esq, October 1, 2013: US08546418 (3 worldwide citation)

The present invention provides a compound of formula I: wherein R1, R2, R2′ and X′ are as defined and described herein, methods of manufacture thereof and compositions thereof, useful for example as peripheral mu opioid receptor antagonists in treatment of side effects of opioid administration.


6
Valeriya N Smolenskaya, Kadum A Al Shareffi, Julio Perez, Syed M Shah, Thomas A Boyd: Crystal forms of (R)-N-methylnaltrexone bromide and uses thereof. Wyeth, Progenics Pharmamceuticals, McCarter & English, Jonathan M Sparks, Maneesh Gulati Esq, August 11, 2015: US09102680 (1 worldwide citation)

The present invention provides a new forms of (R)—N-methylnaltrexone, and compositions thereof, useful as a peripheral mu opioid receptor antagonist.


7
Alfred A Avey, Julio Perez: Preparation and use of (R),(R)-2,2′-bis-methylnaltrexone. Progenics Pharmaceuticals, McCarter & English, Jonathan M Sparks, Maneesh Gulati, December 23, 2014: US08916706

This invention relates to synthesis of (R),(R)-2,2′-bis-MNTX, as shown in Formula (I), and related methods and products.


8
Alfred A Avey, Appavu Chandrasekaren, Harold D Doshan, Julio Perez, Yakov Rotshteyn: Peripheral opioid receptor antagonists and uses thereof. Wyeth, Progenics Pharmaceuticals, McCarter & English, Jonathan M Sparks, Maneesh Gulati Esq, October 7, 2014: US08853232

The present invention provides a compound of formula I: wherein R1, R2, R2′ and X− are as defined and described herein, methods of manufacture thereof and compositions thereof, useful for example as peripheral mu opioid receptor antagonists in treatment of side effects of opioid administration.


9
Harold D Doshan, Julio Perez: Synthesis of (R)-N-methylnaltrexone. Progenics Pharmaceuticals, McCarter & English, Jonathan M Sparks Esq, Maneesh Gulati Esq, March 21, 2017: US09597327

This invention relates to stereoselective synthesis of R-MNTX and intermediates thereof, pharmaceutical preparations comprising R-MNTX or intermediates thereof and methods for their use.


10
Robert Hattori, Julio Perez, Jerrold Scott Stubblefield: Document linkage and forwarding. PASSPORT HEALTH COMMUNICATIONS, Merchant & Gould, May 8, 2018: US09965519

Keeping track of which communications are related, or linked, in a series of communications is an important feature in many electronic document systems. As communication chains grow and branch, however, these systems require meticulous use of unique document identifiers to maintain those links. Syst ...