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Gerrard M Carlson, Veerichetty A Kadhiresan, Julio C Spinelli: Heart rate variability as an indicator of exercise capacity. Cardiac Pacemakers, Nikolai Merserau & Dietz P A, February 15, 2000: US06026320 (337 worldwide citation)

Based upon patient studies indices a high degree of correlation was found between HRV and VO2.sub.max, i.e., the patient's exercise capacity. Based on this finding, a pacing therapy optimization protocol for treating patients with CHF has been devised. The protocol involves first pacing the patient' ...


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Bruce A Tockman, Julio C Spinelli, Rodney W Salo: Method and apparatus to automatically optimize the pacing mode and pacing cycle parameters of a dual chamber pacemaker. Cardiac Pacemakers, Haugen and Nikolai P A, July 30, 1996: US05540727 (324 worldwide citation)

A cardiac stimulating system incorporating a microprocessor-based controller is designed to automatically optimize both the pacing mode and one or more pacing cycle parameters in a way that results in optimization of a cardiac performance parameter, such as cardiac output. For each of a plurality of ...


3
Rodney W Salo, Julio C Spinelli, Bruce A Tockman: Cardiac stimulating apparatus and method for heart failure therapy. Cardiac Pacemakers, Haugen and Nikolai, August 2, 1994: US05334222 (282 worldwide citation)

A cardiac rhythm management device includes a dual-chamber pacemaker especially designed for treating congestive heart failure and a defibrillator as a back-up measure. The device incorporates a programmed microcontroller which is operative to adjust the AV delay of the pacemaker to a minimum or max ...


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Rodney W Salo, Julio C Spinelli, Bruce A Tockman: Cardiac stimulating apparatus and method for heart failure therapy. Cardiac Pacemakers, Haugen and Nikolai P A, December 17, 1996: US05584868 (233 worldwide citation)

A cardiac rhythm management device and method includes a dual-chamber pacemaker especially designed for treating congestive heart failure and a defibrillator as a back-up measure. The device incorporates a programmed microcontroller which is operative to adjust the AV delay of the pacemaker to a min ...


5
Andrew P Kramer, Rodney W Salo, Julio C Spinelli, Bruce H KenKnight: Apparatus and method for reversal of myocardial remodeling with electrical stimulation. Cardiac Pacemakers, Schwegman Lundberg Woessner & Kluth P A, September 30, 2003: US06628988 (194 worldwide citation)

An apparatus and method for reversing ventricular remodeling with electro-stimulatory therapy. A ventricle is paced by delivering one or more stimulatory pulses in a manner such that a stressed region of the myocardium is pre-excited relative to other regions in order to subject the stressed region ...


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Jan P Heemels, Gerrard M Carlson, Julio C Spinelli: Data logging system for implantable cardiac device. Cardiac Pacemakers, Haugen and Nikolai P A, February 18, 1997: US05603331 (183 worldwide citation)

An implantable cardiac rhythm management device (pacemaker or defibrillator) having circuitry for determining the interval between two successive natural ventricular depolarization signals, includes the capability of computing and storing histogram arrays of heart rate variability data over a prolon ...


9
Rodney W Salo, Julio C Spinelli, Bruce A Tockman: Automated programmable stimulating device to optimize pacing parameters and method. Cardiac Pacemakers, Haugen and Nikolai, January 30, 1996: US05487752 (147 worldwide citation)

A method and apparatus for automatically optimizing a cardiac performance parameter of the heart, such as its cardiac output mean arterial pressure pO.sub.2 or pCO.sub.2. The performance parameter is optimized by periodically pacing the heart for a short period of time with stimulating pulses having ...


10
Gerrard M Carlson, Bruce R Jones, Julio C Spinelli: Acceleration sensed safe upper rate envelope for calculating the hemodynamic upper rate limit for a rate adaptive cardiac rhythm management device. Cardiac Pacemakers, Haugen and Nikolai P A, August 11, 1998: US05792195 (146 worldwide citation)

An implantable cardiac rhythm management device includes an accelerometer along with apparatus for processing the analog signal output from the accelerometer for deriving therefrom the time of occurrence of a selected heart sound in relation to a previously occurring ventricular depolarization event ...