1
Shanfun Ching, Patricia Billing, Julian Gordon: Process for immunochromatography with colloidal particles. Abbott Laboratories, Thomas D Brainard, Daniel R Curry, June 9, 1992: US05120643 (248 worldwide citation)

The present invention relates to improved specific binding assay methods, kits and devices utilizing chromatographically mobile specific binding reagents labelled with colloidal particles. Specific binding reagents labelled with colloidal particles such as gold and selenium may be subjected to rapid ...


2
Peter Zaun, Stanley R Bouma, Julian Gordon, John J Kotlarik: Apparatus and method for amplifying and detecting target nucleic acids. Abbott Laboratories, Thomas D Brainard, May 16, 1995: US05415839 (235 worldwide citation)

Methods, devices, apparatus and kits for amplifying and detecting nucleic acid are provided. The apparatus is a two-tier thermal cycling device that operates in conjunction with a reaction/detection unit. A sample is loaded into a reaction chamber of the device which is then mated with a detection c ...


3
Julian Gordon, Michael E McMahon, Shanfun Ching: Chromatographic test strip for determining ligands or receptors. Abbott Laboratories, Donald L Corneglio, Thomas D Brainard, Jeffrey S Sharp, October 2, 1990: US04960691 (174 worldwide citation)

A test strip for analysis of analytes such as antigens, antibodies or polynucleotides employs a chromatographic medium and a solvent capable of transporting reagents and/or sample. Reagents are selected and disposed on the medium such that a labeled (first) reagent arrives at the detection (third) z ...


4
Donald I Stimpson, Julian Gordon, Joanell V Hoijer: Light scattering optical waveguide method for detecting specific binding events. Abbott Laboratories, Thomas D Brainard, Paul D Yasger, February 4, 1997: US05599668 (148 worldwide citation)

A waveguide binding assay method involves detecting the scattering of light directed into the waveguide, the scattering being the result of scattering labels specifically bound to the waveguide within the penetration depth of an evanescent wave. The waveguide may be transparent plastic or glass and ...


5
Julian Gordon, Charles S G Pugh: Lateral flow chromatographic binding assay device. Abbott Laboratories, Jeffrey S Sharp, Thomas D Brainard, September 11, 1990: US04956302 (145 worldwide citation)

The present invention relates to improved specific binding assay devices comprising a chromatographic medium including a reaction site at which a specific binding reagent is immobilized, a sample application well located adjacent to the chromatographic medium and offset upstream from the reaction si ...


6
Stanley R Bouma, Ronald A Coules, Julian Gordon, Eric B Shain, Natalie A Solomon, Peter Zaun: Device and method for amplifying and detecting target nucleic acids. Abbott Laboratories, Thomas D Brainard, Paul D Yasger, July 8, 1997: US05645801 (117 worldwide citation)

Methods, devices, apparatus and kits for amplifying and detecting nucleic acid are provided. The apparatus is a thermal cycling device that operates in conjunction with a reaction/detection unit. A sample is loaded into a reaction chamber of the device which is then sealably mated with a detection c ...


7
Julian Gordon, Michael A Minks: Specific antibody to the native form of 25-oligonucleotides, the method of preparation and the use as reagents in immunoassays or for binding 25-oligonucleotides in biological systems. Leydig Voit & Mayer, April 25, 1989: US04824941 (108 worldwide citation)

A new specific antibody to 5'-terminal mono-, di- or triphosphorylated (2'-5')adenyl-adenoisine oligonucleotides and a method of producing it have been found. The antibody can be used for the quantitative analysis of the oligonucleotides mentioned above in any one of the well known methods of immuno ...


8
Julian Gordon, Theophil Staehelin, Harry Towbin: Electrophoretically transferring electropherograms to nitrocellulose sheets for immuno-assays. Ciba Geigy Corporation, Irving N Feit, June 5, 1984: US04452901 (105 worldwide citation)

Solid supports for proteins consisting of nitrocellulose sheets containing a replica of an electropherogram of proteins as obtained by electrophoretic separation in a gel. Faithful replica of such electropherograms on the nitrocellulose support can be obtained by contacting the gel with a nitrocellu ...


9
Stanley R Bouma, Julian Gordon, Joanell Hoijer, Cynthia Jou, James Rhoads: Method of multiplex ligase chain reaction. Abbott Laboratories, Thomas D Brainard, Paul D Yasger, February 9, 1999: US05869252 (92 worldwide citation)

The invention relates to multiplex ligase chain reaction (LCR). Two or more purative target sequences are selected. For each one, a set of four probes is used simultaneously to amplify the putative sequence if it is present in the sample. Preferably, all the amplicons are labeled with a common label ...


10
Julian Gordon, Richard Hawkes, Evelyn Niday, Harry Towbin: Devices and kits for immunological analysis. Ciba Geigy Corporation, Irving M Fishman, Karen G Kaiser, January 23, 1996: US05486452 (88 worldwide citation)

New devices and kits for solid-phase immuno-assays comprising a solid porous support, preferably in the form of a sheet, where antigens or immuno-globulins or both of them are bound by direct application in any suitable geometry, e.g. as an assay of dots or lines. Such porous supports are suitable f ...