1
Juan Mantelle, David Houze, David Kanios: Bioadhesive compositions and methods for topical administration of active agents. Noven Pharmaceuticals, Foley & Lardner, May 13, 2003: US06562363 (179 worldwide citation)

Bioadhesive compositions in a flexible, finite form for topical application to skin or mucous membranes comprising a composition which results from an admixture of at least one PVP polymer, at least one bioadhesive, optionally a pharmaceutically acceptable solvent suitable for use with an active age ...


2
Juan Mantelle, David Houze: Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures. Noven Pharmaceuticals, Foley & Lardner, November 13, 2001: US06316022 (64 worldwide citation)

A transdermal composition is disclosed which contains a blend of one or more polymers, one or more drugs, at least one of which has a low molecular weight and is liquid at or about room temperatures. The composition is substantially free of water and liquids which have a normal boiling point (a) opt ...


3
Sylvia Rossi Montero, Juan Mantelle, David Kanios, David Houze: Solubility enhancement of drugs in transdermal drug delivery systems and methods of use. Noven Pharmaceuticals, Jay G Kolman, October 15, 2002: US06465004 (43 worldwide citation)

A composition and method for the continuous and controlled transdermal delivery of an active agent comprising a pharmaceutically acceptable active agent carrier and cellulose derivative which provides a solubilizing and stabilizing effect on the active agents incorporated therein.


4
Juan Mantelle, Terese A Dixon: Compositions and methods for treatment of attention deficit disorder and attention deficit/hyperactivity disorder with methylphenidate. Noven Pharmaceuticals NC, Foley & Lardner, April 3, 2001: US06210705 (40 worldwide citation)

The invention relates to a method of treating Attention Deficit Disorder (ADD) and Attention Deficit/Hyperactivity Disorder (ADHD) and compositions for topical application of methylphenidate comprising methylphenidate in a flexible, finite system wherein the methylphenidate is present in an amount s ...


5
Juan Mantelle, David Kanios: Compositions and methods for using low-swell clays in nicotine containing dermal compositions. Noven Pharmaceuticals, Foley & Lardner, March 10, 1998: US05725876 (36 worldwide citation)

A dermal composition for transdermal administration of nicotine includes a blend of: one or more acrylic-based polymers in an amount of from about 10-90% w/w, nicotine in an amount of from about 3 to 15% w/w, and a cohesiveness increasing amount of one or more low-swell clays in an amount of from ab ...


6
David Paul Kanios, Juan Mantelle, Linda Sue Nartker, Victor Albert Raul, Katherine Lynn Ulman: Pressure sensitive adhesive compositions for transdermal drug delivery devices. Dow Corning Corporation, Roger E Gobrogge, January 8, 2002: US06337086 (26 worldwide citation)

A transdermal drug delivery device for the controlled transdermal delivery of an active pharmaceutical agent. The device comprises a drug delivery device comprising an active pharmaceutical agent and a means for its controlled delivery through the skin; and (B) a silicone pressure sensitive adhesive ...


7
Juan Mantelle, Terese A Dixon: Compositions and methods for treatment of attention deficit disorder and attention deficit/hyperactivity disorder with methylphenidate. Noven Pharmaceuticals, Foley & Lardner, February 19, 2002: US06348211 (25 worldwide citation)

The invention relates to a method of treating Attention Deficit Disorder (ADD) and Attention Deficit/Hyperactivity Disorder (ADHD) and compositions for topical application of methylphenidate comprising methylphenidate in a flexible, finite system wherein the methylphenidate is present in an amount s ...


8
Juan Mantelle, David Houze: Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures. Noven Pharmaceuticals, Foley & Lardner, August 9, 2011: US07993671 (9 worldwide citation)

A transdermal composition is disclosed which contains a blend of one or more polymers, one or more drugs, at least one of which has a low molecular weight and is liquid at or about room temperatures. The composition is substantially free of water and liquids which have a normal boiling point (a) opt ...


9
Juan Mantelle: Transdermal estrogen device and delivery. Noven Pharmaceuticals, Foley & Lardner, July 31, 2012: US08231906 (5 worldwide citation)

Described are transdermal drug delivery systems for the transdermal administration of estrogen, comprising a polymer matrix and estrogen. Methods of making and using such systems also are described.


10
David Houze, Juan Mantelle, David Kanios: Dermal composition for controlling drug flux comprising two acrylic adhesive polymers having different functionalities and different solubility parameters. Noven Pharmaceuticals, Foley & Lardner, July 10, 2012: US08216606 (4 worldwide citation)

A dermal composition for administration of a drug comprising a blend of two or more acrylic-based polymers having differing functionalities so as to modulate the drug solubility in the polymer matrix and the delivery rate of the drug, and methods therefor.