1
M Allen Northrup, Raymond P Mariella Jr, Anthony V Carrano, Joseph W Balch: Silicon-based sleeve devices for chemical reactions. Regents of the University of California, Henry P Sartorio, L E Carnahan, December 31, 1996: US05589136 (311 worldwide citation)

A silicon-based sleeve type chemical reaction chamber that combines heaters, such as doped polysilicon for heating, and bulk silicon for convection cooling. The reaction chamber combines a critical ratio of silicon and silicon nitride to the volume of material to be heated (e.g., a liquid) in order ...


2
Peter A Krulevitch, Robin R Miles, Xiao Bo Wang, Raymond P Mariella, Peter R C Gascoyne, Joseph W Balch: Microfluidic DNA sample preparation method and device. The Regents of the Universtiy of California, Alan H Thompson, March 5, 2002: US06352838 (73 worldwide citation)

Manipulation of DNA molecules in solution has become an essential aspect of genetic analyses used for biomedical assays, the identification of hazardous bacterial agents, and in decoding the human genome. Currently, most of the steps involved in preparing a DNA sample for analysis are performed manu ...


3
Joseph W Balch, Anthony V Carrano, James C Davidson, Jackson C Koo: Hybrid slab-microchannel gel electrophoresis system. Regents Of The University Of California, L E Carnahan, Henry P Sartorio, May 5, 1998: US05746901 (32 worldwide citation)

A hybrid slab-microchannel gel electrophoresis system. The hybrid system permits the fabrication of isolated microchannels for biomolecule separations without imposing the constraint of a totally sealed system. The hybrid system is reusable and ultimately much simpler and less costly to manufacture ...


4
Steve P Swierkowski, James C Davidson, Joseph W Balch: Vacuum fusion bonding of glass plates. The Regents of the University of California, L E Carnahan, Alan H Thompson, October 17, 2000: US06131410 (14 worldwide citation)

An improved apparatus and method for vacuum fusion bonding of large, patterned glass plates. One or both glass plates are patterned with etched features such as microstructure capillaries and a vacuum pumpout moat, with one plate having at least one hole therethrough for communication with a vacuum ...


5
Joseph W Balch, Laurence R Brewer, James C Davidson, Joseph R Kimbrough: System and method for chromatography and electrophoresis using circular optical scanning. The Regents of the University of California, Eddie E Scott, Alan H Thompson, October 2, 2001: US06296749 (8 worldwide citation)

A system and method is disclosed for chromatography and electrophoresis using circular optical scanning. One or more rectangular microchannel plates or radial microchannel plates has a set of analysis channels for insertion of molecular samples. One or more scanning devices repeatedly pass over the ...


6
Steve P Swierkowski, James C Davidson, Joseph W Balch: Vacuum fusion bonded glass plates having microstructures thereon. The Regents of the University of California, L E Carnahan, Alan H Thompson, October 16, 2001: US06301931 (4 worldwide citation)

An improved apparatus and method for vacuum fusion bonding of large, patterned glass plates. One or both glass plates are patterned with etched features such as microstructure capillaries and a vacuum pumpout moat, with one plate having at least one hole therethrough for communication with a vacuum ...


7
J Courtney Davidson, Joseph W Balch: Modified electrokinetic sample injection method in chromatography and electrophoresis analysis. The Regents of the University of California, L E Carnahan, Alan H Thompson, November 20, 2001: US06319379 (3 worldwide citation)

A sample injection method for horizontal configured multiple chromatography or electrophoresis units, each containing a number of separation/analysis channels, that enables efficient introduction of analyte samples. This method for loading when taken in conjunction with horizontal microchannels allo ...


8
James C Davidson, Joseph W Balch: Vacuum pull down method for an enhanced bonding process. The Regents of the University of California, L E Carnahan, December 14, 1999: US06000243 (2 worldwide citation)

A process for effectively bonding arbitrary size or shape substrates. The process incorporates vacuum pull down techniques to ensure uniform surface contact during the bonding process. The essence of the process for bonding substrates, such as glass, plastic, or alloys, etc., which have a moderate m ...


9
Steve P Swierkowski, James C Davidson, Joseph W Balch: Vacuum fusion bonding of glass plates. The Regents of the University of California, L E Carnahan, Alan H Thompson, September 18, 2001: US06289695 (2 worldwide citation)

An improved apparatus and method for vacuum fusion bonding of large, patterned glass plates. One or both glass plates are patterned with etched features such as microstructure capillaries and a vacuum pumpout moat, with one plate having at least one hole therethrough for communication with a vacuum ...


10
James C Davidson, Joseph W Balch: Micro injector sample delivery system for charged molecules. The Regents of the University of California, L E Carnahan, November 9, 1999: US05980713 (1 worldwide citation)

A micro injector sample delivery system for charged molecules. The injector is used for collecting and delivering controlled amounts of charged molecule samples for subsequent analysis. The injector delivery system can be scaled to large numbers (>96) for sample delivery to massively parallel high t ...