1
Joseph P Vacanti, Charles A Vacanti, Robert S Langer: Neomorphogenesis of cartilage in vivo from cell culture. Massachusetts Institute of Technology, Children s Hospital, Kilpatrick & Cody, August 20, 1991: US05041138 (401 worldwide citation)

Methods and artificial matrices for the growth and implantation of cartilaginous structures and surfaces are disclosed. In the preferred embodiments, chondrocytes are grown on biodegradable, biocompatible fibrous polymeric matrices. Optionally, the cells are proliferated in vitro until an adequate c ...


2
Joseph P Vacanti, Anthony Atala, David J Mooney, Robert S Langer: Massachusetts Institute of Technology, Arnall Golden & Gregory, February 10, 1998: US05716404 (218 worldwide citation)

Methods and compositions are described herein for reconstruction or augmentation of breast tissue. Dissociated cells, preferably muscle cells, are implanted in combination with a suitable biodegradable, polymeric matrix to form new tissue. There are two forms of matrices which can be used: a polymer ...


3
Antonios G Mikos, Georgios Sarakinos, Joseph P Vacanti, Robert S Langer, Linda G Cima: Biocompatible polymer membranes and methods of preparation of three dimensional membrane structures. Massachusetts Institute of Technology, Children s Medical Center Corporation, Arnall Golden & Gregory, May 7, 1996: US05514378 (203 worldwide citation)

Biocompatible porous polymer membranes are prepared by dispersing salt particles in a biocompatible polymer solution. The solvent in which the polymer is dissolved is evaporated to produce a polymer/salt composite membrane. The polymer can then be heated and cooled at a predetermined constant rate t ...


4
Joseph P Vacanti, Robert S Langer: Three-dimensional fibrous scaffold containing attached cells for producing vascularized tissue in vivo. Massachusetts Institute of Technology Children s Medical Center Corporation, Arnall Golden & Gregory, June 23, 1998: US05770417 (171 worldwide citation)

A cell-scaffold composition is prepared in vitro for implanting to produce functional organ tissue in vivo. The scaffold is three-dimensional and is composed of hollow or solid fibers of a biocompatible, synthetic polymer which is biodegradable or non-biodegradable. The fibers of the scaffold may ha ...


5
Charles A Vacanti, Joseph P Vacanti, Martin P Vacanti: Guided development and support of hydrogel-cell compositions. University of Massachusetts, The Children&apos s Medical Center Corporation, Fish & Richardson P C, January 9, 2001: US06171610 (169 worldwide citation)

The invention features a method for generating new tissue by obtaining a liquid hydrogel-cell composition including a hydrogel and tissue precursor cells; delivering the liquid hydrogel-cell composition into a permeable, biocompatible support structure; and allowing the liquid hydrogel-cell composit ...


6
Joseph P Vacanti, Charles A Vacanti, Robert S Langer: Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous structure. Massachusetts Institute of Technology, Children s Medical Center Corporation, Arnall Golden & Gregory, April 7, 1998: US05736372 (168 worldwide citation)

Methods and artificial matrices for the growth and implantation of cartilaginous structures and surfaces and bone are disclosed. In the preferred embodiments, chondrocytes are grown on biodegradable, biocompatible fibrous polymeric matrices. Optionally, the cells are proliferated in vitro until an a ...


7
Venkatram R Shastri, Christine E Schmidt, Robert S Langer, Joseph P Vacanti: Neuronal stimulation using electrically conducting polymers. Children s Medical Center Corporation, Massachusetts Institute of Technology, Mary Rose Clark & Elbing Scozzafava, August 1, 2000: US06095148 (141 worldwide citation)

Methods and support systems are provided for modifying the regeneration, differentiation, or function of cells. In one embodiment, electrically conducting biocompatible polymers may be used alone or in combination with a polymeric support for in vitro nerve cell regeneration, or in vivo to aid in he ...


8
Joseph P Vacanti, Robert S Langer: Three-dimensional fibrous scaffold containing attached cells for producing vascularized tissue in vivo. Massachusetts Institute of Technology, Children s Medical Center Corporation, Arnall Golden & Gregory, June 2, 1998: US05759830 (131 worldwide citation)

A cell-scaffold composition is prepared in vitro for implanting to produce functional organ tissue in vivo. The scaffold is three-dimensional and is composed of fibers of a biocompatible, biodegradable, synthetic polymer. Cells derived from vascularized organ tissue are attached in vitro to the surf ...


9
David T MacLaughlin, Joseph P Vacanti, Patricia K Donahoe, Peter T Masiakos: Delivery of therapeutic biologicals from implantable tissue matrices. The General Hospital Corporation, Thomas J Kowalski, Amy Lesby, Frommer Lawrence Haug, February 17, 2004: US06692738 (125 worldwide citation)

Normal cells, such as fibroblasts or other tissue or organ cell types, are genetically engineered to express biologically active, therapeutic agents, such as proteins that are normally produced in small amounts, for example, MIS, or other members of the TGF-beta family Herceptin™, interferons, andan ...


10
Joseph P Vacanti, Linda G Cima, Michael J Cima: Vascularized tissue regeneration matrices formed by solid free form fabrication techniques. Children s Medical Center Corporation, Massachusetts Institute of Technology, Arnall Golden & Gregory, October 31, 2000: US06139574 (119 worldwide citation)

Solid free-form fabrication (SFF) methods are used to manufacture devices for allowing tissue regeneration and for seeding and implanting cells to form organ and structural components, which can additionally provide controlled release of bioactive agents, wherein the matrix is characterized by a net ...