1
Samuel Weiss, Brent Reynolds, Joseph P Hammang, E Edward Baetge: In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny. NeuroSpheres Holdings, David J Brezner, Jan P Brunelle, Flehr Hohbach Test Albritton & Herbert, May 12, 1998: US05750376 (244 worldwide citation)

A method for producing genetically modified neural cells comprises culturing cells derived from embryonic, juvenile, or adult mammalian neural tissue with one or more growth factors that induce multipotent neural stem cells to proliferate and produce multipotent neural stem cell progeny which includ ...


2
Samuel Weiss, Brent Reynolds, Joseph P Hammang, E Edward Baetge: In vitro growth and proliferation of multipotent neural stem cells and their progeny. Neurospheres, Flehr Hohbach Test Albrition & Herbert, December 22, 1998: US05851832 (209 worldwide citation)

A method for the in vitro proliferation and differentiation of neural stem cells and stem cell progeny comprising the steps of (a) isolating the cells from a mammal, (b) exposing the cells to a culture medium containing a growth factor, (c) inducing the cells to proliferate, and (d) inducing the cel ...


3
Samuel Weiss, Brent Reynolds, Joseph P Hammang, E Edward Baetge: Neural transplantation using proliferated multipotent neural stem cells and their progeny. NeuroSpheres Holdings, Ivor R Elrifi Esq, Christine V Karnakis Esq, Mintz Levin Cohn Ferris Glovsky and Popeo P C, December 24, 2002: US06497872 (111 worldwide citation)

The invention provides methods of transplanting multipotent neural stem cell progeny to a host by obtaining a population of cells derived from mammalian neural tissue containing at least one multipotent CNS multipotent neural stem cell; culturing the neural stem cell in a culture medium containing o ...


4
Edward E Baetge, Joseph P Hammang, Frank T Gentile, Mark D Lindner, Shelley R Winn, Dwaine F Emerich: Delivery of biologically active molecules using cells contained in biocompatible immunoisolatory capsules. CytoTherapeutics, Ivor R Elrifi, Petrina S Hsi, Fish & Neave, June 17, 1997: US05639275 (95 worldwide citation)

This invention provides improved devices and methods for long-term, stable expression of a biologically active molecule using a biocompatible capsule containing genetically engineered cells for the effective delivery of biologically active molecules to effect or enhance a biological function within ...


5
Joseph P Hammang, E Edward Baetge, William G Tsiarias, Peter D Spear: Device and method for treating ophthalmic diseases. Neurotech, Ivor R Elrifi, Mintz Levin Cohn Ferris Glovsky and Popeo P C, October 9, 2001: US06299895 (76 worldwide citation)

A method and device for delivering a biologically active molecule to the eye, either intraocularly or periocularly, and method and device for treating ophthalmic disorders in a patient suffering therefrom.


6
Joseph P Hammang, E Edward Baetge, Peter D Spear, William G Tsiaras: Method for treating ophthalmic diseases. CytoTherapeutics, Mintz Levin Cohn Ferris Glovsky and Popeo P C, May 18, 1999: US05904144 (71 worldwide citation)

The present invention provides novel devices and methods for continuous, controlled delivery of a biologically active molecule to the eye, either intraocularly or periocularly, to treat ophthalmic disorders. A capsule is surgically placed in the desired location in the eye. The capsule includes cell ...


7
Samuel Weiss, Brent Reynolds, Joseph P Hammang, E Edward Baetge: In vivo genetic modification of growth factor-responsive neural precursor cells. NeuroSpheres Holdings, Burns Doane Swecker & Mathis L, June 6, 2000: US06071889 (59 worldwide citation)

Methods for administering genetic material to dividing neural precursor cell populations in vivo are provided. The genetic material may comprise useful genes for neurotransmitters, growth factors, growth factor receptors, and the like. The genetic material is administered to the brain with one or mo ...


8
Edward E Baetge, Joseph P Hammang, Frank T Gentile, Mark D Lindner, Shelley R Winn, Dwaine F Emerich: Compositions and methods for the delivery of biologically active molecules using cells contained in biocompatible capsules. CytoTherapeutics, Ivor R Elrifi, Petrina S Hsi, Fish & Neave, August 5, 1997: US05653975 (56 worldwide citation)

This invention provides improved devices and methods for long-term, stable expression of a biologically active molecule using a biocompatible capsule containing genetically engineered cells for the effective delivery of biologically active molecules to effect or enhance a biological function within ...


9
Malcolm Schinstine, Molly S Shoichet, Frank T Gentile, Joseph P Hammang, Laura M Holland, Brian M Cain, Edward J Doherty, Shelley R Winn, Patrick Aebischer: Method for controlling proliferation and differentiation of cells encapsulated within bioartificial organs. Cytotherapeutics, Ivor R Elrifi, Mintz Levin Cohn Ferris Glovsky and Popeo, August 18, 1998: US05795790 (52 worldwide citation)

Methods and compositions are provided for controlling cell distribution within a bioartificial organ by exposing the cells to a treatment that inhibits cell proliferation, promotes cell differentiation, or affects cell attachment to a growth surface within the bioartificial organ. Such treatments in ...


10
Laura M Holland, Joseph P Hammang, Seth A Rudnick, Michael J Lysaght, Keith E Dionne: Method for implanting encapsulated cells in a host. CytoTherapeutics, Ivor R Elrifi, Barbara A Ruskin, Fish & Neave, August 27, 1996: US05550050 (51 worldwide citation)

This invention provides methods for implanting encapsulated cells in a host comprising exposing cells to restrictive conditions for a sufficient period of time to establish a desired cell property in response to the restrictive conditions and implanting the encapsulated cells in a host, the cell pro ...