1
Jonathan A Eppstein, Deborah A Eppstein, Joseph Kost, Robert S Langer: Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers. Non Invasive Monitoring Company, Thorpe North & Western, October 17, 1995: US05458140 (357 worldwide citation)

A method of enhancing the permeability of the skin or mucosa to an analyte for diagnostic purposed is described utilizing ultrasound or ultrasound plus a chemical enhancer. If desired the ultrasound may be modulated by means of frequency modulation, amplitude modulation, phase modulation and/or comb ...


2
Joseph Kost, Uwe Pliquett, Samir S Mitragotri, Robert S Langer, James C Weaver: Effect of electric field and ultrasound for transdermal drug delivery. Massachusetts Institute of Technology, Arnall Golden & Gregory, March 21, 2000: US06041253 (356 worldwide citation)

Transdermal transport of molecules during sonophoresis (delivery or extraction) can be further enhanced by application of an electric field, for example, electroporation or iontophoresis. In a preferred embodiment the ultrasound is low frequency ultrasound which induces cavitation of the lipid layer ...


3
Tuan A Elstrom, Scott Kellogg, Joseph Kost, Samir S Mitragotri, Nicolas F Warner, Steve DiMatteo: Preparation for transmission and reception of electrical signals. Sontra Medical, Hunton & Williams, May 3, 2005: US06887239 (234 worldwide citation)

The invention provides a convenient and non-invasive means to prepare cells, tissues, and organs for electrical transmission and reception. In an embodiment of the invention, a control method comprises the use of at least one skin electrode, as a reference electrode, and an electrical sensor to meas ...


4
Mark E Johnson, Samir S Mitragotri, Daniel Blankschtein, Robert S Langer, Michael Pishko, Joseph Kost: Chemical and physical enhancers and ultrasound for transdermal drug delivery. Massachusetts Institute of Technology, Arnall Golden & Gregory, September 7, 1999: US05947921 (211 worldwide citation)

Transdermal transport of molecules during sonophoresis (delivery or extraction) can be further enhanced by providing chemical enhancers which increase the solubility of the compound to be transported and/or lipid bilayer solubility, and/or additional driving forces for transport, such as mechanical ...


5
Stephen Rowe, Joseph Kost, Samir S Mitragotri, Michael Pishko, Matthew Davis: Ultrasound enhancement of transdermal transport. Sontra Medical, Arnall Golden & Gregory, May 22, 2001: US06234990 (190 worldwide citation)

Methods and devices for application of ultrasound to a small area of skin for enhancing transdermal transport. An ultrasound beam having a first focal diameter is channelled into a beam having a second, smaller diameter without substantial loss of energy. Higher energy ultrasound can be used while c ...


6
Joseph Kost, Drora Levy, Robert S Langer: Ultrasound enhancement of transdermal drug delivery. Massachusetts Institute of Technology, Patrea L Pabst, August 30, 1988: US04767402 (182 worldwide citation)

The present invention is a method using ultrasound to enhance permeation of molecules through the skin and into the blood stream, at a controlled rate. Depending on the drug being infused through the skin, the rate of permeation is increased as well as the efficiency of transfer. Drugs which may not ...


7
Stephen Rowe, Joseph Kost, Samir S Mitragotri, Michael Pishko, Matthew Davis: Ultrasound enhancement of transdermal transport. Sontra Medical, Holland & Knight, December 10, 2002: US06491657 (161 worldwide citation)

Methods and devices for application of ultrasound to a small area of skin for enhancing transdermal transport. An ultrasound beam having a first focal diameter is channelled into a beam having a second, smaller diameter without substantial loss of energy. Higher energy ultrasound can be used while c ...


8
Linda Custer, Tuan A Elstrom, Scott C Kellogg, Joseph Kost, Nicholas F Warner: System, method, and device for non-invasive body fluid sampling and analysis. Sontra Medical, Hunton & Williams, June 27, 2006: US07066884 (154 worldwide citation)

A system, method, and device for non-invasive body fluid sampling is provided. According to one embodiment of the present invention, the system includes a controller that controls the generation of ultrasound; an ultrasonic applicator that applies the ultrasound to an area of biological membrane; a ...


9
Joseph Kost, Samir S Mitragotri, Robert S Langer: Sonophoretic enhanced transdermal transport. Sontra Medical, Arnall Golden & Gregory, February 20, 2001: US06190315 (126 worldwide citation)

Methods for enhanced transdermal transport wherein the application of ultrasound is required only once for repeated or sustained transdermal extraction or delivery, over a period of time, rather than prior to each extraction or delivery. The method is applicable to analyte extraction, as well as for ...


10
Joseph Kost, Robert S Langer: Ultrasound enhancement of transbuccal drug delivery. Massachusetts Institute of Technology, Kilpatrick & Cody, August 14, 1990: US04948587 (84 worldwide citation)

A method using ultrasound for enhancing and controlling transbuccal permeation of a molecule, including drugs, antigens, vitamins, inorganic and organic compounds, and various combinations of these substances, through the buccal membranes and into the circulatory system. The frequency and intensity ...