1
Joseph J Nunes, Jill Milne, Jean Bemis, Roger Xie, Chi B Vu, Pui Yee Ng, Jeremy S Disch: Sirtuin modulating compounds. Sirtris Pharmaceuticals, Ropes & Gray, March 18, 2008: US07345178 (45 worldwide citation)

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to agin ...


2
David M Armistead, Jean E Bemis, Lucian V DiPietro, Stephanie D Geuns Meyer, Gregory J Habgood, Joseph L Kim, Joseph J Nunes, Vinod F Patel, Leticia M Toledo Sherman: Kinase inhibitors. Amgen, Joseph W Bulock, October 16, 2007: US07282504 (40 worldwide citation)

The invention relates to inhibitors of kinases, compositions comprising the inhibitors, and methods of using the inhibitors and inhibitor compositions. The inhibitors and compositions comprising them are useful for treating disease or disease symptoms. The invention also provides for methods of maki ...


3
Joseph J Nunes, Xiaotian Zhu, Patricia Amouzegh, Chiara Ghiron, David N Johnson, Eoin Christopher Power: Substituted heterocyclic compounds and methods of use. Amgen, G Prabhakar Reddy, March 17, 2009: US07504396 (32 worldwide citation)

The present invention relates to pyrimidine or pyridine carboxamides or pharmaceutically-acceptable salts thereof. Also included is a method of treatment of inflammation, inhibition of T cell activation and proliferation, arthritis, rheumatoid arthritis, psoriatic arthritis, osteoarthritis, organ tr ...


4
Joseph J Nunes, Jill Milne, Jean Bemis, Roger Xie, Chi B Vu, Pui Yee Ng, Jeremy S Disch, Thomas Salzmann, David Armistead: Sirtuin modulating compounds. Sirtris Pharmaceuticals, Ropes & Gray, December 21, 2010: US07855289 (18 worldwide citation)

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to agin ...


5
Joseph J Nunes, Jill Milne, Jean Bemis, Roger Xie, Chi B Vu, Pui Yee Ng, Jeremy S Disch: Sirtuin modulating compounds. Sirtris Pharmaceuticals, Ropes & Gray, January 10, 2012: US08093401 (17 worldwide citation)

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to agin ...


6
Joseph J Nunes, Jill Milne, Jean Bemis, Roger Xie, Chi B Vu, Pui Yee Ng, Jeremy S Disch, Thomas Salzmann, David Armistead: Sirtuin modulating compounds. Sirtris Pharmaceuticals, Ropes & Gray, January 3, 2012: US08088928 (17 worldwide citation)

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to agin ...


7
Joseph J Nunes, Jill Milne, Jean Bemis, Roger Xie, Chi B Vu, Pui Yee Ng, Jeremy S Disch: Sirtuin modulating compounds. Sirtris Pharmaceuticals, Ropes & Gray, October 25, 2011: US08044198 (13 worldwide citation)

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to agin ...


8
David M Armistead, Jean E Bemis, Daniel Elbaum, Gregory J Habgood, Perry M Novak, Joseph J Nunes, Leticia M Toledo Sherman: Kinase inhibitors. Amgen, Frank S Ungemach, Stuart L Watt, December 17, 2002: US06495558 (10 worldwide citation)

The invention relates to inhibitors of kinases, compositions comprising the inhibitors, and methods of using the inhibitors and inhibitor compositions. The inhibitors and compositions comprising them are useful for treating disease or disease symptoms. The invention also provides for methods of maki ...


9
Michele Potashman, Tae Seong Kim, Steven Bellon, Shon Booker, Yuan Cheng, Joseph L Kim, Andrew Tasker, Ning Xi, Shimin Xu, Jean Christophe Harmange, George Borg, Matthew Weiss, Brian L Hodous, Russell Graceffa, William H Buckner, Craig E Masse, Deborah Choquette, Matthew W Martin, Julie Germain, Lucian V DiPietro, Stuart C Chaffee, Joseph J Nunes, John L Buchanan, Gregory J Habgood, David C McGowan, Douglas A Whittington, Daniel La, Vinod F Patel: Compounds and methods of use. Amgen, Joseph W Bulock, Ronald S Hermenau, October 14, 2008: US07435823 (9 worldwide citation)

Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and ...


10
John L Buchanan, Daniel Elbaum, Matthew W Martin, David C McGowan, Perry M Novak, Joseph J Nunes: Substituted heterocyclic compounds and methods of use. Amgen, G Prabhaker Reddy, October 28, 2008: US07442698 (5 worldwide citation)

The present invention relates to pyrimidine or pyridine carbamate compounds having the general Formula I: and pharmaceutically acceptable salts or derivatives thereof. Also included are methods of treatment of various diseases and conditions, including inflammation, inhibition of T cell activation a ...