1
Joseph H Schulman, Orville R Rule III, David I Whitmoyer, Ronald J Lebel, Joseph Y Lucisano, Alfred E Mann: Glucose monitoring system. Alfred E Mann Foundation For Scientific Research, Fitch Even Tabin & Flannery, March 12, 1996: US05497772 (931 worldwide citation)

A glucose monitoring system continuously measures the glucose concentration in a patient's blood, provides an indication of the rate of change of such concentration, and determines whether the measured concentration and rate of change are within certain preset limits. If not, an audible and/or visua ...


2
Joseph H Schulman, Ronald J Lebel, Joseph Y Lucisano, Alfred E Mann, Orville Rey Rule III, David I Whitmoyer: Patient monitoring system. Alfred E Mann Foundation for Scientific Research, Fitch Even Tabin & Flannery, August 11, 1998: US05791344 (889 worldwide citation)

A patient monitoring system measures the concentration of a particular substance in a patient's tissue, blood, or other bodily fluids, provides an indication of the rate of change of such concentration, and determines whether the measured concentration and rate of change are within certain preset li ...


3
Joseph H Schulman, Carla M Mann: System of implantable devices for monitoring and/or affecting body parameters. Alfred E Mann Foundation for Scientific Research and Advanced Bionics, Freilich Hornbaker & Rosen, March 27, 2001: US06208894 (826 worldwide citation)

A system for monitoring and/or affecting parameters of a patient's body and more particularly to such a system comprised of a system control unit (SCU) and one or more other devices, preferably battery-powered, implanted in the patient's body, i.e., within the envelope defined by the patie ...


4
Joseph H Schulman, Orville Rey Rule III, David I Whitmoyer, Ronald J Lebel, Joseph Y Lucisano, Alfred E Mann: Glucose sensor assembly. Alfred E Mann Foundation for Scientific Research, Fitch Even Tabin & Flannery, August 26, 1997: US05660163 (779 worldwide citation)

A glucose monitoring system continuously measures the glucose concentration in a patient's blood, provides an indication of the rate of change of such concentration, and determines whether the measured concentration and rate of change are within certain preset limits. If not, an audible and/or visua ...


5
Joseph H Schulman, Rajiv Shah: Electrochemical sensor and integrity tests therefor. Alfred E Mann Foundation, Abraham N Seidman, July 11, 2000: US06088608 (717 worldwide citation)

An electrochemical sensor includes electronic circuitry for automatically performing on a periodic basis, e.g., every 1 to 24 hours, specified integrity tests which verify proper operation of the sensor.


6
Joseph H Schulman, Gerald E Loeb, John C Gord, Primoz Strojnik: Implantable microstimulator. Alfred E Mann Foundation for Scientific Research, L Lee Humphries, March 16, 1993: US05193539 (634 worldwide citation)

An addressable, implantable microstimulator is substantially encapsulated within a hermetically-sealed housing inert to body fluids, and of a size and shape capable of implantation in a living body, by expulsion through a hypodermic needle. Power and information for operating the microstimulator is ...


7
Joseph H Schulman, Charles L Byers, Gerald E Adomian, Michael S Colvin: Implantable enzyme-based monitoring systems having improved longevity due to improved exterior surfaces. Alfred E Mann Foundation, Abraham N Seidman, September 12, 2000: US06119028 (612 worldwide citation)

An implantable enzyme-based monitoring system suitable for long term in vivo use to measure the concentration of prescribed substances such as glucose is provided. In one embodiment, the implantable enzyme-based monitoring system includes at least one sensor assembly, an outer membrane surrounding t ...


8
Joseph H Schulman, Gerald E Loeb, John C Gord, Primoz Strojnik: Structure and method of manufacture of an implantable microstimulator. Alfred E Mann Foundation for Scientific Research, L Lee Humphries, March 16, 1993: US05193540 (603 worldwide citation)

An implantable microstimulator has a structure which is manufactured to be substantially encapsulated within a hermetically-sealed housing inert to body fluids, and of a size and shape capable of implantation in a living body, by expulsion through a hypodermic needle. The internal structure of the m ...


9
Joseph H Schulman, Charles L Byers, John C Gord, Rajiv Shah, Lyle Dean Canfield: Implantable substrate sensor. Alfred E Mann Foundation, Lee Jay Mandell, July 10, 2001: US06259937 (581 worldwide citation)

An implantable substrate sensor has electronic circuitry and electrodes formed on opposite sides of a substrate. A protective coating covers the substrate, effectively hermetically sealing the electronic circuitry under the coating. Exposed areas of the electrodes are selectively left uncovered by t ...


10
Michael S Colvin, Joseph H Schulman, Lyle Dean Canfield, Rajiv Shah: Implantable enzyme-based monitoring systems adapted for long term use. Alfred E Mann Foundation, Abraham N Seidman, June 27, 2000: US06081736 (559 worldwide citation)

Improved implantable monitoring systems suitable for long-term in vivo use to measure the concentration of one or more prescribed substances, such as glucose are described herein. In particular, an implantable enzyme-based glucose monitoring system is described that includes at least one of the foll ...



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