1
Joseph A Izatt, Manish D Kulkarni, Michael V Sivak: Depth-resolved spectroscopic optical coherence tomography. Thompson Hine & Flory, December 14, 1999: US06002480 (269 worldwide citation)

A method is described for determining depth-resolved backscatter characteristics of scatterers within a sample, comprising the steps of: acquiring a plurality of sets of cross-correlation interferogram data using an interferometer having a sample arm with the sample in the sample arm, wherein the sa ...


2
Manish D Kulkarni, Joseph A Izatt, Michael V Sivak: Image enhancement in optical coherence tomography using deconvolution. Thompson Hine & Flory, November 30, 1999: US05994690 (215 worldwide citation)

The present invention provides an improved optical coherence tomography system and involves estimating the impulse response (which is indicative of the actual reflecting and scattering sites within a tissue sample) from the output interferometric signal of an interferometer according to the followin ...


3
Joseph A Izatt, Manish D Kulkarni, Siavash Yazdanfar, Andrew Rollins, Michael V Sivak: Doppler flow imaging using optical coherence tomography. Thompson Hine & Flory, December 21, 1999: US06006128 (172 worldwide citation)

A method for generating a velocity-indicating, tomographic image of a sample in an optical coherence tomography system includes the steps of (a) acquiring cross-correlation data from the interferometer; (b) generating a grayscale image from the cross-correlation data indicative of a depth-dependent ...


4
Joseph A Izatt, Michael V Sivak, Andrew Rollins, Akihiro Horii, Tadashi Hirata, Shuhei Iizuka: Optical imaging device. University Hospital of Cleveland, Olympus Optical, Pilsbury Winthrop, May 13, 2003: US06564089 (160 worldwide citation)

An Optical Coherence Tomography (OCT) device irradiates a biological tissue with low coherence light, obtains a high resolution tomogram of the inside of the tissue by low-coherent interference with scattered light from the tissue, and is provided with an optical probe which includes an optical fibe ...


5
Andrew M Rollins, Joseph A Izatt, Volker Westphal, Siavash Yazdanfar: Aspects of basic OCT engine technologies for high speed optical coherence tomography and light source and other improvements in optical coherence tomography. Case Western Reserve University, University Hospitals of Cleveland, Renner Otto Boisselle and Sklar, June 13, 2006: US07061622 (152 worldwide citation)

An optical coherence tomography (OCT) system including an interferometer provides illuminating light along a first optical path to a sample and an optical delay line and collects light from the sample along a second optical path remitted at several scattering angles to a detector. In one embodiment, ...


6
Joseph A Izatt, Divakar K Rao, Changhuei Yang, Michael A Choma, Siavash Yazdanfar, Andrew M Rollins, Brian E Applegate: Method for optical coherence tomography imaging with molecular contrast. Duke University, Case Western Reserve University, Jenkins Wilson Taylor & Hunt P A, July 11, 2006: US07075658 (142 worldwide citation)

Spatial information, such as concentration and displacement, about a specific molecular contrast agent, may be determined by stimulating a sample containing the agent, thereby altering an optical property of the agent. A plurality of optical coherence tomography (OCT) images may be acquired, at leas ...


7
Michael Choma, Joseph A Izatt, Anjul Davis: Methods and systems for reducing complex conjugate ambiguity in interferometric data. Duke University, Myers Bigel Sibley & Sajovec, February 26, 2008: US07336366 (138 worldwide citation)

A complex conjugate ambiguity can be resolved in an Optical Coherence Tomography (OCT) interferogram. A reference light signal is propagated along a reference path. A sample light signal is impinged on a sample reflector. The reference light signal is frequency shifted with respect to the sample lig ...


8
Joseph A Izatt, Michael Choma, Changhuei Yang: System and method for low coherence broadband quadrature interferometry. Duke University, Fleshner & Kim, March 28, 2006: US07019838 (123 worldwide citation)

A quadrature broadband interferometry system and method obtains a complete complex interferometric signal instantaneously in both homodyne and heterodyne systems in a simple, compact, and inexpensive setup. This is accomplished by separating interferometric components from non-interferometric compon ...


9
Volker Westphal, Andrew M Rollins, Joseph A Izatt: Method and system for quantitative image correction for optical coherence tomography. Case Western Reserve University, University Hospitals of Cleveland, Renner Otto Boisselle and Sklar, July 4, 2006: US07072047 (123 worldwide citation)

A method of correcting optical coherence tomography (OCT) image data obtained from a layered media sample includes identifying at least one interface from the obtained OCT data and correcting the OCT data for distortion at the at least one interface. The OCT image data can be corrected for extrinsic ...


10
Andrew M Rollins, Joseph A Izatt, Volker Westphal, Cameron J Pedersen, Siavash Yazdanfar: Phase-referenced doppler optical coherence tomography. Case Western Reserve University, University of Hospitals of Cleveland, Renner Otto Boisselle and Sklar, February 28, 2006: US07006232 (96 worldwide citation)

A phase-referenced Doppler optical coherence tomography (OCT) system includes a low-coherence optical radiation source and a reference source co-propagated to a sample arm and a reference arm. The low-coherence and reference optical radiation reflected from the reference and arms is detected by a pa ...