1
Nam Sok Choi, Jorge Heller: Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates). Alza Corporation, Paul L Sabatine, Thomas E Ciotti, Edward L Mandell, June 6, 1978: US04093709 (263 worldwide citation)

The invention concerns orthoester and orthocarbonate polymers having a repeating mer comprising a hydrocarbon radical and a symmetrical dioxycarbon unit of the general formula: ##STR1## WHEREIN R.sub.1 is a multivalent hydrocarbon radical, R.sub.2 and R.sub.3 are hydrocarbon radicals with at least o ...


2
Alma U Daniels, Jorge Heller: Biodegradable composites for internal medical use. SRI International, University of Utah, Morrison & Foerster, April 28, 1992: US05108755 (202 worldwide citation)

A family of composites suitable for use as materials of construction for implantable medical devices is disclosed. In the most preferred embodiment, the substrate polymer is an ortho ester polymer formed by the reaction of a ketene acetal having a functionality of two or more with a polyol. Also in ...


3
Jorge Heller, Robert F Helwing, Donald W Penhale: Polymers of di- (and higher functionality) ketene acetals and polyols. SRI International, Edward B Gregg, Donovan J DeWitt, December 8, 1981: US04304767 (127 worldwide citation)

This invention concerns ortho ester polymers having repeating mer units represented by the general formulas: ##STR1## The polymers are formed by a condensation reaction between ketene acetals having a functionality of two or more and hydroxyl containing compounds having a functionality of two or mor ...


4
Nam Sok Choi, Jorge Heller: Poly(carbonates). Alza Corporation, Paul L Sabatine, Thomas E Ciotti, Edward L Mandell, March 14, 1978: US04079038 (122 worldwide citation)

Poly(orthoester carbonates) and poly(orthocarbonate carbonates) having a repeating linear carbonate unit and a recurring symmetrical dioxycarbon moiety with a plurality of organic groups pendant from the carbon atom thereof are disclosed. The polymers are represented by the structural formula: ##STR ...


5
Jorge Heller, Richard W Baker: Bioerodible system for delivering drug manufactured from poly(carboxylic acid). Alza Corporation, Paul L Sabatine, Thomas E Ciotti, Edward L Mandell, February 10, 1981: US04249531 (117 worldwide citation)

A device for the controlled continuous administration of an active agent to an environment of use is disclosed. The device comprises a body of erodible agent release rate controlling material containing an agent dispersed therethrough; the rate controlling material is a hydrophobic poly(carboxylic a ...


6
Nam S Choi, Jorge Heller: Novel orthoester polymers and orthocarbonate polymers. Alza Corporation, Paul L Sabatine, Thomas E Ciotti, Edward L Mandell, December 25, 1979: US04180646 (101 worldwide citation)

The invention concerns orthoester and orthocarbonate polymers having a repeating mer comprising a hydrocarbon radical and a symmetrical dioxycarbon unit of the general formula: ##STR1## wherein R.sub.1 is a multivalent hydrocarbon radical, R.sub.2 and R.sub.3 are hydrocarbon radicals with at least o ...


7
Nam S Choi, Jorge Heller: Erodible agent releasing device comprising poly(orthoesters) and poly(orthocarbonates). ALZA Corporation, Paul L Sabatine, Thomas E Ciotti, Edward L Mandell, February 6, 1979: US04138344 (100 worldwide citation)

The invention concerns orthoester and orthocarbonate polymers having a repeating mer comprising a hydrocarbon radical and a symmetrical dioxycarbon unit of the general formula: ##STR1## WHEREIN R.sub.1 is a multivalent hydrocarbon radical, R.sub.2 and R.sub.3 are hydrocarbon radicals with at least o ...


8
Nam S Choi, Jorge Heller: Structured orthoester and orthocarbonate drug delivery devices. Alza Corporation, Paul L Sabatine, Thomas E Ciotti, Edward L Mandell, December 26, 1978: US04131648 (100 worldwide citation)

The invention concerns orthoester and orthocarbonate polymers having a repeating mer comprising a hydrocarbon radical and a symmetrical dioxycarbon unit of the general formula: ##STR1## WHEREIN R.sub.1 is a multivalent hydrocarbon radical, R.sub.2 and R.sub.3 are hydrocarbon radicals with at least o ...


9
Jorge Heller, Steven Y Ng: PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers. Advanced Polymer Systems, Heller Ehrman White & McAuliffe, August 17, 1999: US05939453 (70 worldwide citation)

PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers have both hydrophilic and hydrophobic blocks. They form micelles in aqueous solution, making them suitable for encapsulation or solubilization of hydrophobic or water-insoluble materials; and they also form bioerodible matrices for the sustained ...


10
Lin Shu Liu, Michael Froix, Jorge Heller, Steven Y Ng: Bioerodible porous compositions. Advanced Poymer Systems, Heller Ehrman White & McAuliffe, May 29, 2001: US06238705 (67 worldwide citation)

A composition for the sequestration and sustained delivery of an active ingredient in the form of porous particles, the composition comprising the product of the controlled dehydration of particles formed by the reaction of a polymeric anionic material with a polyvalent cation. The composition may b ...