1
Pierre Jean Fran├žois Layrolle, Klaas de Groot, Joost Dick de Bruijn, Clemens A van Blitterswijk, Yuan Huipin: Method for coating medical implants. IsoTis, John P Iwanicki, Banner & Witcoff, March 27, 2001: US06207218 (83 worldwide citation)

The present invention relates to a method for coating a medical implant, wherein the implant is submersed in an aqueous solution of magnesium, calcium and phosphate ions through which a gaseous weak acid is passed, the solution is degassed, and the coating is allowed to precipitate onto the implant. ...


2
Eugenia Ribeiro de Sousa Fidalgo Leitao, Joost Dick De Bruijn, Hai Bo Wen, Klaas De Groot: Device for incorporation and release of biologically active agents. IsoTis, Banner & Witcoff, February 5, 2002: US06344061 (65 worldwide citation)

The invention provides an implantable device coated with a layer of calcium phosphate and optionally one or more biologically active substances such as growth factors, lipis, (lipo)polysaccharides, hormones, proteins, antibiotics or cytostatics. The device can be obtained by a nanotechnology process ...


3
Eugenia Ribeiro de Sousa Fidalgo Leitao, Joost Dick De Bruijn, Hai Bo Wen, Klaas De Groot: Device for incorporation and release of biologically active agents. IsoTis, Banner & Witcoff, October 24, 2000: US06136369 (53 worldwide citation)

The invention provides an implantable device coated with a layer of calcium phosphate and optionally one or more biologically active substances such as growth factors, lipis, (lipo)polysaccharides, hormones, proteins, antibiotics or cytostatics. The device can be obtained by a nanotechnology process ...


4
Pierre Jean Fran├žois Layrolle, Klaas de Groot, Joost Dick de Bruijn, Clemens A van Blitterswijk, Yuan Huipin: Method for coating medical implants. IsoTis, Banner & Witcoff, May 11, 2004: US06733503 (39 worldwide citation)

The present invention relates to a method for coating a medical implant, wherein the implant is submersed in an aqueous solution of magnesium, calcium and phosphate ions through which a gaseous weak acid is passed, the solution is degassed, and the coating is allowed to precipitate onto the implant. ...


5
Eugenia Ribeiro de Sousa Fidalgo Leitao, Joost Dick De Bruijn, Hai Bo Wen, Klaas De Groot: Device for incorporation and release of biologically active agents. IsoTis, Banner & Witcoff, November 7, 2000: US06143948 (29 worldwide citation)

The invention provides an implantable device coated with a layer of calcium phosphate and optionally one or more biologically active substances such as growth factors, lipids, (lipo)polysaccharides, hormones, proteins, antibiotics or cytostatics. The device can be obtained by a nanotechnology proces ...


6
Joost Dick De Bruijn, Yvonne Pearl Bovell, Jennigje Van Den Brink, Clemens Antoni Van Blitterswijk: Device for tissue engineering bone. IsoTis, Banner & Witcoff, May 8, 2001: US06228117 (14 worldwide citation)

A device for bone tissue engineering is described which comprises a scaffold material consisting of a bioactive, osteoconductive and bone-bonding segmented thermoplastic copolyester and cultured osteogenic or osteoprogenitor cells, especially bone cells. The copolyester consists essentially of a mul ...


7
Clemens Antoni Van Blitterswijk, Joost Dick De Bruijn, Yvonne Pearl Bovell: Method for in vitro production of bone. IsoTis, Banner & Witcoff, October 9, 2001: US06299650 (9 worldwide citation)

The invention relates to a method for in vitro production of bone tissue, comprising the steps of:


8
Clemens Antoni Van Blitterswijk, Joost Dick De Bruijn, Yvonne Pearl Bovell: Method for in vitro production of bone. IsoTis, Banner & Witcoff, November 28, 2000: US06152964 (5 worldwide citation)

The invention relates to a method for in vitro production of bone tissue, comprising the steps of:


9
Joost Dick De Bruijn, Gerrit Jacobus Meijer: Tissue regeneration. Progentix Orthobiology, Leydig Voit & Mayer, December 6, 2011: US08071083 (3 worldwide citation)

The present invention relates to a method of treating a tissue defect in a human or animal body comprising the steps of implanting into said body an unseeded scaffold; allowing or effecting a wound healing response at the site of said defect; allowing said scaffold to be vascularized until a substan ...


10
Joost Dick de Bruijn, Gerhardus Johannes M Tibbe, Sandra Claudia da Silva Madureira Mendes: Cell culture medium containing growth factors and L-glutamine. IsoTis, Banner & Witcoff, January 4, 2005: US06838284 (1 worldwide citation)

The invention relates to a culture medium for culturing cells, in particular human cells in a process for tissue engineering bone. The medium comprises glucose, a mineral, a vitamin, a growth factor and L-glutamine, wherein the L-glutamine is present in a concentration of at least 300 mg/L.