1
Leon W M M Terstappen, Galla Chandra Rao, Jonathan W Uhr, Emilian V Racila, Paul A Liberti: Methods and reagents for the rapid and efficient isolation of circulating cancer cells. Immunivest Corporation, Board of Regents The University of Texas System, Dann Dorfman Herrell and Skillman, April 2, 2002: US06365362 (162 worldwide citation)

A highly sensitive assay is disclosed which combines immunomagnetic enrichment with multiparameter flow cytometric and immunocytochemical analysis to detect, enumerate and characterize carcinoma cells in the blood. The assay can detect one epithelial cell or less in 1 ml of blood and has a greater s ...


2
Jonathan W Uhr, Ellen S Vitetta, Richard H Scheuermann: Epitope-specific monoclonal antibodies and immunotoxins and uses thereof. Board of Regents The University of Texas, Arnold White & Durkee, November 11, 1997: US05686072 (133 worldwide citation)

The anti-tumor activity of a mixture of anti-CD22 and anti-CD19 immunotoxins is shown to be significantly enhanced in SCID/Daudi mice with disseminated human Daudi lymphoma. Unexpectedly identical enhancement was observed employing a combination of the anti-CD22 immunotoxin with unconjugated anti-CD ...


3
Leon W M M Terstappen, Galla Chandra Rao, Jonathan W Uhr, Emilian V Racila, Paul A Liberti: Methods and reagents for the rapid and efficient isolation of circulating cancer cells. Immunivest Corporation, Dann Dorfman Herrell and Skillman, November 11, 2003: US06645731 (106 worldwide citation)

A highly sensitive assay is disclosed which combines immunomagnetic enrichment with multiparameter flow cytometric and immunocytochemical analysis to detect, enumerate and characterize carcinoma cells in the blood. The assay can detect one epithelial cell or less in 1 ml of blood and has a greater s ...


4
Jonathan W Uhr, Ellen S Vitetta: Methods for screening antibodies for use as immunotoxins. Board of Regents, September 3, 1991: US05045451 (68 worldwide citation)

The present disclosure described an assay for screening monoclonal antibodies for their potential as highly cytotoxic immunotoxins. The assay involves treating cells with dilutions of the test antibody followed by a Fab fragment of a secondary antibody coupled to an A chain toxin ("indirect assay"). ...


5
Jonathan W Uhr, Ellen S Vitetta: Immunotoxin conjugates employing toxin B chain moieties. Board of Regents University of Texas System, Arnold White & Durkee, May 12, 1987: US04664911 (61 worldwide citation)

Compositions and methods for potentiating the cytotoxic activity of immunogotoxin conjugates are provided. The compositions of the present invention include a selective binding agent such as an antibody coupled to a toxin B chain moiety such as ricin B chain.


6
Maria Ana Ghetie, Jonathan W Uhr, Ellen S Vitetta: Compositions and methods for homoconjugates of antibodies which induce growth arrest or apoptosis of tumor cells. Board of Regents The University of Texas System, Fulbright & Jaworski L, April 9, 2002: US06368596 (50 worldwide citation)

This invention discloses monoclonal antibodies (MAbs) which have little or no signaling activity as monomers become potent anti-tumor agents when they are converted into homoconjugates. The homoconjugates exert anti-growth activity by signaling G


7
Leon W M M Terstappen, Galla Chandra Rao, Jonathan W Uhr, Emilian V Racila, Paul A Liberti: Methods and reagents for the rapid and efficient isolation of circulating cancer cells. Immunivest Corporation, Joseph F Aceto, James L Wilcox, February 19, 2008: US07332288 (48 worldwide citation)

A highly sensitive assay is disclosed which combines immunomagnetic enrichment with multiparameter flow cytometric and immunocytochemical analysis to detect, enumerate and characterize carcinoma cells in the blood. The assay can detect one epithelial cell or less in 1 ml of blood and has a greater s ...


8
Jonathan W Uhr, Ellen S Vitetta: Anti-immunoglobulin toxin conjugates useful in the treatment of B cell tumors. Board of Regents The University of Texas System, Arnold White & Durkee, December 20, 1988: US04792447 (15 worldwide citation)

Highly specific antibodies directed against immunoglobulin determinants coupled to one or more toxin molecules provide antibody-toxin conjugates which are useful in selectively inhibiting the growth of target immunoglobulin generating cells. The antibody-toxin conjugate consists of an antibody speci ...


9
Ellen S Vitetta, Jonathan W Uhr: Therapeutic compositions comprising a CD4 peptide and methods of treatment of HIV infections. Board of Regents The University of Texas System, Arnold White & Durkee, June 16, 1998: US05767072 (8 worldwide citation)

Disclosed are methods and compositions for the treatment of HIV infections through the specific elimination of cells which express HIV env determinants such as gp120. The compositions of the invention include toxin conjugates composed of a CD4 derived gp120 binding ligand conjugated to a toxin A cha ...


10
Jonathan W Uhr, Ellen S Vitetta, Louis J Picker, Richard H Scheuermann: Method for identifying tumor cells in cell cycle arrest. Board of Regents The University of Texas System, Arnold White & Durkee, March 18, 1997: US05612185 (8 worldwide citation)

Disclosed are methods for the identification and characterization of tumor cell types present within malignant populations, and novel methods of cancer treatment. Tumor cells in cell cycle arrest have been identified, purified and characterized according to their size, altered morphology, surface ph ...