1
Jon W Hayenga, Louis R Piloco: Method and apparatus for rapid capture of focused microscopic images. NeoPath, Leone & Moffa P A, June 15, 1999: US05912699 (91 worldwide citation)

A high speed image capture apparatus includes a camera with an integration period between consecutive flashes of an illuminating light pulse, where the camera has an image read out period and an image output. A timer for provides a strobe output representative of the start of a flash. An image captu ...


2
Jon W Hayenga, Clinton L Williams: Valve for use in microfluidic structures. Jerrold J Litzinger, August 13, 2002: US06431212 (84 worldwide citation)

A valve for use in laminated plastic microfluidic structures. The valve comprises first, second, and third layers of flexible material separated by first and second spacing layers to form microfluidic channels, and having an actuator section to selectively isolate the microfluidic channels from each ...


3
Keith L Frost, Jon W Hayenga, James A Stephanick, Robert C Schmidt: Automatic focusing of biomedical specimens apparatus. NeoPath, Moffa & Associates P A, July 8, 1997: US05647025 (70 worldwide citation)

A method for automatically focusing on a slide includes the steps of locating a coverslip, acquiring images from predetermined focal depths in the slide, and starting at an initial focal depth proximate the surface of the coverslip. A set of predetermined characteristics within each of the images ar ...


4
Bernhard H Weigl, Clinton L Williams, Jon W Hayenga, Ronald L Bardell, Thomas E Schulte: Pumpless microfluidics. Micronics, Seed IP Law Group PLLC, June 1, 2004: US06743399 (66 worldwide citation)

A microfluidic device which operates without the need for an external power source. The device includes a body structure, at least one microscale channel within the structure, a port for introducing fluid into the channel, and a power source internal to the structure for propelling the fluid through ...


5
William E Ortyn, Jon W Hayenga, Louis R Piloco: Apparatus for illumination stabilization and homogenization. NeoPath, Hans I Sun, Emil Moffa, October 14, 1997: US05677762 (59 worldwide citation)

An illumination device provides temporally, spatially and angularly stable illumination for microscopic evaluations. An arc lamp serves as the light source. An input optical train gathers and focuses the light through an aperture stop to place an image of the arc incident on an input aperture of a l ...


6
Jon W Hayenga, Robert C Schmidt: Method and apparatus for dynamic correction of microscopic image signals. NeoPath, Leone & Moffa, November 1, 1994: US05361140 (58 worldwide citation)

A circuit is provided for correcting an image signal received from a camera wherein the camera includes a plurality of charge coupled devices, each for providing a light signal indicative of the intensity of light incident thereon and wherein the plurality of light signals from the plurality of char ...


7
Keith L Frost, Seho Oh, Jon W Hayenga, Kim J Hansen: Imaging system transfer function control method and apparatus. NeoPath, Leone & Moffa P A, April 15, 1997: US05621519 (56 worldwide citation)

Accurately measuring and controlling the system transfer function of an imaging system, by eliminating interference from aliases. An image is captured of an image primitive with a uniaxial pattern, oriented at an angle to the primary axes of a sampling array. In order to accurately measure the syste ...


8
Jon W Hayenga, Bernhard H Weigl, Ronald L Bardell, Christopher J Morris: Microfluidic channel network device. Micronics, Seed IP Law Group PLLC, May 29, 2007: US07223371 (51 worldwide citation)

Described herein is microfluidic device for joining fluids and a related method for doing the same. The device according to the present invention includes a microfluidic junction, an outlet channel, and a plurality of circuit units. A microfluidic junction is an area for converging multiple fluids. ...


9
Wayne L Breidford, Christy A Lancaster, Jon W Hayenga, Ronald L Bardell, Jeffrey F Tonn, Bernhard H Weigl: System and method for heating, cooling and heat cycling on microfluidic device. Micronics, Seed IP Law Group PLLC, January 19, 2010: US07648835 (31 worldwide citation)

An integrated heat exchange system on a microfluidic card. According to one aspect of the invention, the portable microfluidic card has a heating, cooling and heat cycling system on-board such that the card can be used portably. The microfluidic card includes one or more reservoirs containing exothe ...


10
Shih Jong J Lee, Paul S Wilhelm, Michael G Meyer, Wendy R Bannister, Chih Chau L Kuan, William E Ortyn, Larry A Nelson, Keith L Frost, Jon W Hayenga: Cytological slide scoring apparatus. Neo Path, George A Leone, Emil Moffa, Hans Sun, August 3, 1999: US05933519 (29 worldwide citation)

The invention detects areas of interest at low magnification, locating possible abnormal cells or other cells of interest using image processing and statistical pattern recognition techniques. Next, at high magnification, the areas identified at low magnification are re-examined. The information fro ...