1
Francis Barany, John Zebala, Deborah Nickerson, Robert J Kaiser Jr, Leroy Hood: Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease. Cornell Research Foundation, Nixon Hargrave Devans & Doyle, February 27, 1996: US05494810 (363 worldwide citation)

The present invention relates to the cloning of the gene of a thermophilic DNA ligase, from Thermus aquaticus strain HB8, and the use of this ligase in a ligase chain reaction (LCR) assay for the detection of specific sequences of nucleotides in a variety of nucleic acid samples, and more particular ...


2
Francis Barany, John Zebala, Deborah Nickerson, Robert J Kaiser Jr, Leroy Hood: Thermostable ligase mediated DNA amplification system for the detection of genetic diseases. Cornell Research Foundation, California Institute of Technology, Nixon Hagargrave Devans & Doyle, November 3, 1998: US05830711 (119 worldwide citation)

The present invention relates to the cloning of the gene of a thermophilic DNA ligase, from Thermus aquaticus strain HB8, and the use of this ligase for the detection of specific sequences of nucleotides in a variety of nucleic acid samples, and more particularly in those samples containing a DNA se ...


3
Francis Barany, John Zebala, Deborah Nickerson, Robert J Kaiser Jr, Leroy Hood: Thermostable ligase mediated DNA amplification system for the detection of genetic diseases. Cornell Research Foundation, California Institute of Technology, Nixon Peabody, April 25, 2000: US06054564 (90 worldwide citation)

The present invention relates to the cloning of the gene of a thermophilic DNA ligase, from Thermus aquaticus strain HB8, and the use of this ligase for the detection of specific sequences of nucleotides in a variety of nucleic acid samples, and more particularly in those samples containing a DNA se ...


4
John Zebala, Barton A Kamen: Aminopterin dosage forms and methods for inflammatory disorders. Aminopterin, Jeffrey B Oster, March 6, 2012: US08129383

There is disclosed dosage forms and methods for treating a patient with an inflammatory disorder with a therapeutically effective amount of aminopterin, or a pharmaceutically acceptable salt thereof, that achieve efficacy without concomitant toxicity. Specifically, there is disclosed a method for tr ...


5
Francis Barany, John Zebala, Deborah Nickerson, Robert J Kaiser, Leroy Hood: Thermostable ligase mediated DNA amplification system for the detection of genetic diseases. Nixon Peabody, March 11, 2004: US20040048308-A1

The present invention relates to the cloning of the gene of a thermophilic DNA ligase, from Thermus aquaticus strain HB8, and the use of this ligase in assays for the detection of specific sequences of nucleotides in a variety of nucleic acid samples, and more particularly in those samples containin ...


6
John Zebala: Aminopterin dosage forms. Syntrix Biosystems, Syntrix Biosystems, April 24, 2008: US20080096893-A1

Embodiments of the present invention provide dosage forms and methods for treating a patient with an inflammatory disorder with a therapeutically effective amount of aminopterin, or a pharmaceutically acceptable salt thereof, that achieve efficacy without concomitant toxicity. Within certain embodim ...


7
Barton A Kamen, John Zebala: Aminopterin Dosage Forms and Methods for Inflammatory Disorders. Syntrix Biosystems, Syntrix Biosystems, May 8, 2008: US20080108621-A1

There is disclosed dosage forms and methods for treating a patient with an inflammatory disorder with a therapeutically effective amount of aminopterin, or a pharmaceutically acceptable salt thereof, that achieve efficacy without concomitant toxicity. Specifically, there is disclosed a method for tr ...


8
Barton A Kamen, John Zebala: Aminopterin Dosage Forms and Methods for Inflammatory Disorders. May 24, 2012: US20120128703-A1

There is disclosed dosage forms and methods for treating a patient with an inflammatory disorder with a therapeutically effective amount of aminopterin, or a pharmaceutically acceptable salt thereof, that achieve efficacy without concomitant toxicity. Specifically, there is disclosed a method for tr ...