1
John Wallace Parce, Anne R Kopf Sill, Luc J Bousse: High throughput screening assay systems in microscale fluidic devices. Caliper Technologies Corporation, Matthew B Murphy, Jonathan Alan Quine, Townsend and Townsend and Crew, August 24, 1999: US05942443 (567 worldwide citation)

Microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.


2
Anne R Kopf Sill, John Wallace Parce: Microfluidic systems incorporating varied channel dimensions. Caliper Technologies Corporation, Matthew B Murphy, December 1, 1998: US05842787 (486 worldwide citation)

The present invention is generally directed to improved microfluidic devices, systems and methods of using same, which incorporate channel profiles that impart significant benefits over previously described systems. In particular, the presently described devices and systems employ channels having, a ...


3
John Wallace Parce, Michael R Knapp, Calvin Y H Chow, Luc Bousse: Controlled fluid transport in microfabricated polymeric substrates. Caliper Technologies Corporation, Matthew B Murphy, Jonathan Alan Quine, Townsend and Townsend and Crew, March 23, 1999: US05885470 (344 worldwide citation)

Microfluidic devices are provided for the performance of chemical and biochemical analyses, syntheses and detection. The devices of the invention combine precise fluidic control systems with microfabricated polymeric substrates to provide accurate, low cost miniaturized analytical devices that have ...


4
John Wallace Parce, Anne R Kopf Sill: Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems. Caliper Technologies, Matthew B Murphy, February 9, 1999: US05869004 (281 worldwide citation)

The present invention is generally directed to methods, apparatus and systems for use in performing in situ dilution or concentration of a particular subject material in a microfluidic device or system. These methods and apparatus may generally be integrated with other microfluidic operations and/or ...


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Michael Knapp, John Wallace Parce, Luc J Bousse, Anne R Kopf Sill: Closed-loop biochemical analyzers. Caliper Technologies, Jonathan Alan Quine, Matthew B Murphy, Law Offices of Jonathan Alan Quine, May 22, 2001: US06235471 (235 worldwide citation)

Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components and drug screening are provided. Microfluidic devices, systems and methods for using these devices and ...


7
Calvin Y H Chow, John Wallace Parce, Richard J McReynolds, Colin B Kennedy, Luc J Bousse: Controller/detector interfaces for microfluidic systems. Caliper Technologies, Matthew B Murphy, November 23, 1999: US05989402 (232 worldwide citation)

The present invention is generally directed to improved methods, structures and systems for interfacing microfluidic devices with ancillary systems that are used in conjunction with such devices. These systems typically include control and monitoring systems for controlling the performance of the pr ...


8
Michael Knapp, John Wallace Parce, Luc J Bousse, Anne R Kopf Sill: Microfluidic devices and methods for separation. Caliper Technologies, Matthew B Murphy, Angela P Horne, Quine Intellectual Property Law Group P C, September 3, 2002: US06444461 (231 worldwide citation)

Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components and drug screening are provided. Microfluidic devices, systems and methods for using these devices and ...


9
Anne R Kopf Sill, John Wallace Parce: Microfluidic systems incorporating varied channel dimensions. Caliper Technologies, Matthew B Murphy, September 28, 1999: US05957579 (200 worldwide citation)

The present invention is generally directed to improved microfluidic devices, systems and methods of using same, which incorporate channel profiles that impart significant benefits over previously described systems. In particular, the presently described devices and systems employ channels having, a ...


10
John Wallace Parce: Micropump. Caliper Technologies, Matthew B Murphy, January 11, 2000: US06012902 (188 worldwide citation)

The present invention generally provides a micropump that utilizes electroosmotic pumping of fluid in one channel or region to generate a pressure based flow of material in a connected channel, where the connected channel has substantially no electroosmotic flow generated. Such pumps have a variety ...