1
John W Shell: Sustained-release oral drug dosage form. DepoMed Systems, Irell & Manella, April 16, 1991: US05007790 (168 worldwide citation)

Sustained-release oral drug-dosage forms that release drug in solution at a rate controlled by the solubility of the drug are described. The dosage form comprises a tablet or capsule which comprises a plurality of particles of a dispersion of a limited solubility drug in a hydrophilic, water-swellab ...


2
John W Shell, Jenny Louie Helm: Gastric-retentive, oral drug dosage forms for the controlled-release of sparingly soluble drugs and insoluble matter. DepoMed, Townsend and Townsend and Crew, October 26, 1999: US05972389 (161 worldwide citation)

Controlled-release oral drug dosage forms that comprise a tablet or capsule containing a plurality of particles of a solid-state drug dispersed in a swellable/erodible polymer, such as poly(ethylene oxide) are described. Once ingested, the tablet or capsule disintegrates to disperse the particles wi ...


3
John W Shell, Jenny Louie Helm, Micheline Markey: Extending the duration of drug release within the stomach during the fed mode. DepoMed, Townsend and Townsend and Crew, January 22, 2002: US06340475 (159 worldwide citation)

Drugs are formulated as unit oral dosage forms by incorporating them into polymeric matrices comprised of hydrophilic polymers that swell upon imbibition of water to a size that is large enough to promote retention of the dosage form in the stomach during the fed mode. The oral formulation is design ...


4
John W Shell, Robert M Gale: Ocular insert housing steroid in two different therapeutic forms. Alza Corporation, Paul L Sabatine, Edward L Mandell, December 8, 1981: US04304765 (131 worldwide citation)

An ocular insert and an ocular composition are disclosed. The insert and the composition comprises a steroid in two different forms.


5
John W Shell, Jenny Louie Helm, Micheline Markey: Extending the duration of drug release within the stomach during the fed mode. DepoMed, M Henry Heines, Townsend and Townsend and Crew, October 21, 2003: US06635280 (114 worldwide citation)

Drugs are formulated as unit oral dosage forms by incorporating them into polymeric matrices comprised of hydrophilic polymers that swell upon imbibition of water to a size that is large enough to promote retention of the dosage form in the stomach during the fed mode. The oral formulation is design ...


6
John W Shell, Robert M Gale: Ocular preparation housing steroid in two different therapeutic forms. Alza Corporation, Paul L Sabatine, Edward L Mandell, Steven F Stone, October 23, 1984: US04478818 (109 worldwide citation)

An ocular insert and an ocular composition are disclosed. The insert and the composition comprises a steroid in two different forms.


7
John W Shell: Alkyl-substituted cellulose-based sustained-release oral drug dosage forms. Depomed, Townsend and Townsend and Crew, December 10, 1996: US05582837 (105 worldwide citation)

Sustained release oral drug dosage forms that comprise a tablet or capsule containing a plurality of particles of a solid-state drug dispersed in alkyl cellulose such as hydroxyethylcellulose or hydroxypropylcellulose. Once ingested the tablet or capsule disintegrates to disperse the particles into ...


8
Anwar A Hussain, Takeru Higuchi, John W Shell: Bioerodible ocular device. Alza Corporation, Thomas E Ciotti, Paul L Sabatine, Edward L Mandell, June 1, 1976: US03960150 (100 worldwide citation)

An ocular insert for the continuous controlled administration of a predetermined therapeutically effective dosage of drug to the eye over a prolonged period of time. The device meters the flow of drug by means of a drug release rate controlling material. The insert bioerodes in the environment of th ...


9
John W Shell, Robert M Gale: Drug delivery system for controlled ocular therapy. ALZA Corporation, Paul L Sabatine, Edward L Mandell, August 4, 1981: US04281654 (85 worldwide citation)

A drug delivery system is disclosed useful for controlled ocular therapy. The system is manufactured as an ocular insert, and it comprises a beta-adrenergic blocking osmotic solute and a parasympathomimetic osmotic solute dispersed in a polymer with the solutes surrounded by the polymer. The system, ...


10
Takeru Higuchi, Anwar A Hussain, John W Shell: Bioerodible ocular device. Alza Corporation, Thomas E Ciotti, Paul L Sabatine, Edward L Mandell, October 19, 1976: US03986510 (71 worldwide citation)

An ocular insert for the continuous controlled administration of a predetermined therapeutically effective dosage of drug to the eye over a prolonged period of time. The device meters the flow of drug by means of a drug release rate controlling material. The insert bioerodes in the environment of th ...