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John W Kozarich, Gary F Musso, Bernard Malfroy Camine: Increasing blood-brain barrier permeability with permeabilizer peptides. Alkermes, Hamilton Brook Smith & Reynolds, December 7, 1993: US05268164 (95 worldwide citation)

Polypeptides called receptor mediated permeabilizers (RMP) increase the permeability of the blood-brain barrier to molecules such as therapeutic agents or diagnostic agents. These receptor mediated permeabilizers are more efficacious than bradykinin in causing the blood-brain barrier to become more ...


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John W Kozarich, Gary F Musso, Bernard Malfroy Camine: Increasing blood-brain barrier permeability with permeabilizer peptides. Alkermes, Hamilton Brook Smith & Reynolds, April 9, 1996: US05506206 (67 worldwide citation)

Polypeptides called receptor mediated permeabilizers (RMP) increase the permeability of the blood-brain barrier to molecules such as therapeutic agents or diagnostic agents. These receptor mediated permeabilizers are more efficacious than bradykinin in causing the blood-brain barrier to become more ...


3
John W Kozarich, Gary F Musso, Bernard Malfroy Camine: Increasing blood-brain barrier permeability with permeabilizer peptides. Alkermes, Hamilton Brook Smith & Reynolds P C, November 11, 1997: US05686416 (56 worldwide citation)

Peptides called receptor mediated permeabilizers (RMP) increase the permeability of the blood-brain barrier to molecules such as therapeutic agents or diagnostic agents. The permeabilizer A-7 or conformational analogues can be intravenously co-administered to a host together with molecules whose des ...


4
John W Kozarich, Robert E Rhoads: Purification of the messenger RNA cap-binding protein. Yale University, Walter J McMurray, December 1, 1987: US04710566 (2 worldwide citation)

The synthesis of a new affinity medium, the p-aminophenyl-.gamma.-ester of 7-methylguanosine-5'-triphosphate coupled to Sepharose, for use in affinity chromatography is claimed. An improved method in terms of speed and purity for the isolation of messenger ribonucleic acid cap-binding protein is cla ...


5
Sidney M Hecht, John W Kozarich: Alkylations employing in situ generation of diazoalkane alkylation reagents. Massachusetts Institute of Technology, Arthur A Smith Jr, David E Brook, Martin M Santa, June 15, 1976: US03963698 (2 worldwide citation)

Alkylation processes wherein diazoalkane alkylation reagents are generated in situ and utilized to alkylate substrates are disclosed. These processes utilize the relatively slow base-catalyzed decomposition of an N-alkyl, N-nitrosourea to produce a corresponding diazoalkane alkylation reagent, follo ...


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