1
John W Gibson, Stacey A Sullivan, John C Middleton, Arthur J Tipton: High viscosity liquid controlled delivery system and medical or surgical device. Southern Biosystems, Bruce D Gray Esq, Kilpatrick Stockton, July 2, 2002: US06413536 (115 worldwide citation)

The present invention relates to novel nonpolymeric compounds and compositions that form liquid, high viscosity materials suitable for the delivery of biologically active substances in a controlled fashion, and for use as medical or surgical devices. The materials can optionally be diluted with a so ...


2
John W Gibson, Richard J Holl, Arthur J Tipton: Emulsion-based processes for making microparticles. Southern BioSystems, Holland & Knight, September 18, 2001: US06291013 (101 worldwide citation)

Processes for making microparticles, preferably containing an active agent, are provided. In a preferred embodiment, the process involves preparing (1) a dispersed phase containing an agent in a solution of polymer and a first solvent; (2) a continuous phase containing a surfactant, a second solvent ...


3
John W Gibson, Arthur J Tipton: High viscosity liquid controlled delivery system and medical or surgical device. Durect Corporation, Thomas P McCracken, May 30, 2006: US07053209 (48 worldwide citation)

The present invention relates to novel nonpolymeric compounds and compositions that form liquid, high viscosity materials suitable for the delivery of biologically active substances in a controlled fashion, and for use as medical or surgical devices. The materials can optionally be diluted with a so ...


4
Patrick J Burns, John W Gibson, Arthur J Tipton: Compositions suitable for controlled release of the hormone GnRH and its analogs. Southern BioSystems, Bruce D Kilpatrick Stockton Gray Esq, April 18, 2000: US06051558 (42 worldwide citation)

A liquid composition for the controlled release of gonodotropin releasing hormone (GnRH) or its analogs is provided that includes: (i) a non-polymeric, non-water soluble liquid carrier material (HVLCM) of viscosity of at least 5,000 cP at 37.degree. C. that does not crystallize neat under ambient or ...


5
John W Gibson, Stacey S Miller, John C Middleton, Arthur J Tipton: High viscosity liquid controlled delivery system and medical or surgical device. Durect Corporation, Thomas P McCracken, November 16, 2010: US07833543 (38 worldwide citation)

The present invention relates to novel nonpolymeric compounds and compositions that form liquid, high viscosity materials suitable for the delivery of biologically active substances in a controlled fashion, and for use as medical or surgical devices. The materials can optionally be diluted with a so ...


6
John W Gibson, Richard J Holl, Arthur J Tipton: Emulsion-based processes for making microparticles. Southern Biosystems, Holland & Knight, August 27, 2002: US06440493 (38 worldwide citation)

Processes for making microparticles, preferably containing an active agent, are provided. In a preferred embodiment, the process involves preparing (1) a dispersed phase containing an agent in a solution of polymer and a first solvent; (2) a continuous phase containing a surfactant, and a second sol ...


7
Richard L Dunn, John W Gibson, Carlton A Eddy, Leonard E Laufe: Antithrombotic/thrombolytic suture and methods of making and using the same. Southern Research Institute, Texas Health Science Center, Needle & Rosenberg, June 27, 1989: US04841968 (31 worldwide citation)

The controlled first-order release of either an antithrombotic or thrombolytic agent from a sutures at an anastomosis site is disclosed which prevents postoperative thrombosis and improves vascular patency in animals. A suitable polymer, such as polycaprolactone, is blended with prostacyclin or anal ...


8
Su Il Yum, Grant Schoenhard, Arthur J Tipton, John W Gibson, John C Middleton: Oral drug delivery system. Durect Corporation, March 13, 2012: US08133507 (28 worldwide citation)

Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.


9
Susan Mancini Cady, Claude Macar, John W Gibson: Extended release growth promoting two component composition. Akzo Nobel, Southern BioSystems, William M Blackstone, December 24, 2002: US06498153 (21 worldwide citation)

An extended release composition comprising a first composition comprising growth promoters and a second composition comprising growth promoters and a biodegradable polymer is described. A method of increasing weight gain in food animals utilizing the composition, a pharmaceutical dosage form contain ...


10
Su Il Yum, Grant Schoenhard, Arthur J Tipton, John W Gibson, John C Middleton: Oral drug delivery system. Durect Corporation, April 3, 2012: US08147870 (16 worldwide citation)

Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.