1
John T Santini Jr, Michael J Cima, Robert S Langer: Microchip drug delivery devices. Massachusetts Institute of Technology, Arnall Golden & Gregory, August 25, 1998: US05797898 (401 worldwide citation)

Microchips are provided, which control both the rate and time of release of multiple chemical substances and which allow for the release of a wide variety of molecules in either a continuous or pulsatile manner. In all of the preferred embodiments, a material that is impermeable to the drugs or othe ...


2
John T Santini Jr, Charles E Hutchinson, Scott A Uhland, Michael J Cima, Robert S Langer, Dennis Ausiello: Microfabricated devices for the delivery of molecules into a carrier fluid. MicroChips, Sutherland Asbill & Brennan, December 10, 2002: US06491666 (257 worldwide citation)

Apparati and methods are provided for the delivery of molecules to a site via a carrier fluid. The apparati include microchip devices which have reservoirs containing the molecules for release. The apparati and methods provide for active or passive controlled release of the molecules. Preferred embo ...


3
John T Santini Jr, Charles E Hutchinson: Implantable drug delivery stents. MicroCHIPS, Sutherland Asbill & Brennan, December 2, 2003: US06656162 (247 worldwide citation)

Devices for the controlled release of one or more drugs are provided. The devices include an implantable stent, at least two reservoirs in the stent, and a release system contained in each of the at least two reservoirs, wherein the release system comprises one or more drugs for release.


4
John T Santini Jr, Michael J Cima, Robert S Langer: Fabrication of microchip drug delivery devices. Massachusetts Institute of Technology, Arnall Golden & Gregory, September 26, 2000: US06123861 (226 worldwide citation)

Fabrication methods are provided for microchips that control both the rate and time of release of multiple chemical substances and allow for the release of a wide variety of molecules in either a continuous or pulsatile manner. In all of the preferred embodiments, a material that is impermeable to t ...


5
Scott A Uhland, Benjamin F Polito, Stephen J Herman, John T Santini Jr, John M Maloney: Methods for hermetically sealing microchip reservoir devices. MicroCHIPS, Sutherland Asbill & Brennan, December 7, 2004: US06827250 (190 worldwide citation)

Methods are provided for hermetically sealing the reservoirs of microchip devices and for hermetically sealing the substrate assemblies in a hermetic packaging structure. In one embodiment, the method comprises (1) providing a primary substrate having a front side and a back side, the substrate comp ...


6
Norman F Sheppard Jr, John T Santini Jr, Stephen J Herman, Michael J Cima, Robert S Langer, Dennis Ausiello: Microchip reservoir devices using wireless transmission of power and data. MicroCHIPS, Sutherland Asbill & Brennan, June 5, 2007: US07226442 (183 worldwide citation)

Devices, systems, and methods are provided for wirelessly powering and/or communicating with microchip devices used for the controlled exposure and release of reservoir contents, such as drugs, reagents, and sensors. In one embodiment, the system includes (1) a microchip device comprising a substrat ...


7
John T Santini Jr, Norman F Sheppard Jr, Chung Chang Young, Robert S Langer: Microfabricated devices for the storage and selective exposure of chemicals and devices. MicroCHIPS, Sutherland Asbill & Brennan, April 22, 2003: US06551838 (166 worldwide citation)

Microchip devices are provided which include a substrate having a plurality of reservoirs containing a secondary device, a reacting component, or a combination thereof. At least one barrier layer covers each reservoir to isolate the reservoir contents from one or more environmental components outsid ...


8
Norman F Sheppard Jr, Christina M Feakes, John T Santini Jr: Microchip reservoir devices and facilitated corrosion of electrodes. MicroCHIPS, Sutherland Asbill & Brennan, August 10, 2004: US06773429 (150 worldwide citation)

Methods and devices are provided for enhancing corrosion of an electrode in a biocompatible fluid. The method comprises (1) placing a primary electrode and a counter electrode in an electroconductive biocompatible fluid to form an electrochemical cell; and (2) applying a time-varying potential, thro ...


9
John T Santini Jr, Michael J Cima, Scott Albert Uhland: Thermally-activated microchip chemical delivery devices. MicroCHIPS, Sutherland Asbill & Brennan, December 30, 2003: US06669683 (149 worldwide citation)

Microchip delivery devices are provided that control both the rate and time of release of molecules. In one embodiment, an implantable microchip device is provided for the controlled delivery of drug molecules into a patient comprising at least one substrate; a plurality of reservoirs in the substra ...


10
John T Santini Jr, Michael J Cima, Norman F Sheppard Jr, Nolan T Flynn, Scott A Uhland, Zouhair Sbiaa, John M Maloney: Microchip devices with improved reservoir opening. Massachusetts Institute of Technology, Sutherland Asbill & Brennan, April 5, 2005: US06875208 (140 worldwide citation)

Microchip devices and methods of manufacture thereof are provided to increase the uniformity and reliability of active exposure and release of microchip reservoir contents. In one embodiment, the microchip device for the controlled release or exposure of molecules or secondary devices comprises: (1) ...