1
John S Kent, Danny H Lewis, Lynda M Sanders, Thomas R Tice: Microencapsulation of water soluble active polypeptides. Syntex, Ellen J Wise, Tom M Moran, Alan Krubiner, June 23, 1987: US04675189 (333 worldwide citation)

This invention concerns novel sustained release microcapsule compositions comprising water-soluble, hormonally active polypeptides and, optionally, a polymer hydrolysis modifying agent encapsulated in a biocompatible, biodegradable polymer.


2
John S Kent: Cholesterol matrix delivery system for sustained release of macromolecules. Syntex, Ellen J Buckles, Tom M Moran, Alan M Krubiner, June 5, 1984: US04452775 (221 worldwide citation)

Delivery systems for releasing macromolecular active agents to a body site at a controlled rate for a prolonged period of time, comprising a cholesteric matrix permeable to passage of the macromolecular active agent by diffusion, are disclosed. The cholesteric matrix comprises cholesterol powder and ...


3
Orest Olejnik, Patrick M Hughes, John S Kent: Sterile bioerodible occular implant device with a retinoid for improved biocompatability. Allergan Sales, Walter A Hackler, June 13, 2000: US06074661 (130 worldwide citation)

An implantable device is provided which incorporates a retinoid for improving the biocompatability of the device in eye tissue. The device may be bioerodible for the purpose of systemically or locally releasing a therapeutic agent in tissue or it may be a permanent implant which includes a surface t ...


4
Orest Olejnik, Patrick M Hughes, John S Kent: Implant device with a retinoid for improved biocompatibility. Allergan, Walter A Hackler, March 25, 2003: US06537568 (104 worldwide citation)

An implant device is provided which incorporates a retinoid for improving the biocompatibility of the device in tissue. The device may be bioerodible for the purpose of systemically or locally releasing a therapeutic agent in tissue or it may be a permanent implant which includes a surface treated w ...


5
James V C Boyles, John S Kent: Storage and delivery of multi-dose, preservative-free pharmaceuticals. Allergan, Walter A Hackler, September 17, 2002: US06450994 (79 worldwide citation)

Apparatus for multi-dose delivery of preservative-free pharmaceuticals includes a film laminate flexible container for holding and maintaining a sterile drug formulation. A nozzle disposed within the container and in fluid communication therewith provides for dropwise dispensing of the formulation f ...


6
Orest Olejnik, Patrick M Hughes, John S Kent: Implant device with a retinoid for improved biocompatibility. Allergan Sales, Walter A Hackler, October 23, 2001: US06306426 (77 worldwide citation)

An implant device is provided which incorporates a retinoid for improving the biocompatibility of the device in tissue. The device may be bioerodible for the purpose of systemically or locally releasing a therapeutic agent in tissue or it may be a permanent implant which includes a surface treated w ...


7
Orest Olejnik, Patrick M Hughes, John S Kent: Implant device with a retinoid for improved biocompatibility. Allergan, Walter A Hackler, September 24, 2002: US06455062 (66 worldwide citation)

An implant device is provided which incorporates a retinoid for improving the biocompatibility of the device in tissue. The device may be bioerodible for the purpose of systemically or locally releasing a therapeutic agent in tissue or it may be a permanent implant which includes a surface treated w ...


8
Charles H Hsiao, John S Kent: Controlled release naproxen and naproxen sodium tablets. Syntex, Ellen J Wise, Tom M Moran, Alan M Krubiner, February 7, 1989: US04803079 (41 worldwide citation)

A controlled release tablet for once-daily oral administration of about 500-1200 mg of naproxen or naproxen sodium, said tablet comprising a homogeneous matrix comprising about 4-9 weight percent of hydroxypropyl methylcellulose having a number average molecular weight in the range of from about 80, ...


9
Charles H Hsiao, John S Kent: Controlled release naproxen and naproxen sodium tablets. Syntex, Ellen J Buckles, Tom M Moran, Alan M Krubiner, February 18, 1986: US04571333 (39 worldwide citation)

A controlled release tablet for once-daily oral administration of about 500-1200 mg of naproxen or naproxen sodium, said tablet being a homogeneous matrix comprising about 4-9 weight percent of hydroxypropylmethylcellulose having a number average molecular weight in the range of from about 80,000 to ...


10
Martin Katz, John S Kent: Inert core implant pellet. Syntex Corporation, Tom M Moran, Joseph I Hirsch, December 25, 1979: US04180560 (35 worldwide citation)

A novel spherical implant pellet containing estradiol, estradiol benzoate, or mixtures thereof as the sole active ingredients which exhibits a substantially constant drug release rate over a timer period and substantially abrupt termination of drug release at the end of the time period is prepared w ...