1
John R Daniels, Terry R Knapp: Process for augmenting connective mammalian tissue with in situ polymerizable native collagen solution. The Board of Trustees of Leland Stanford Junior University, Thomas E Ciotti, April 6, 1976: US03949073 (236 worldwide citation)

A method for augmenting hard or soft connective tissue, such as skin, tendon, cartilage, bone or interstitium, in a living mammal comprising implanting a proteolytic enzyme-solubilized, purified, native, in situ polymerizable collagen solution into the mammal at the augmentation site. The solution p ...


2
John R Daniels, Erik T Engelson, Garbriel B Vegh: Catheter device. Target Therapeutics, Ciotti & Murashige, April 7, 1987: US04655746 (230 worldwide citation)

A catheter device for transferring fluid material to or from one or more selected-length segment of a vessel. The device includes first and second catheters, each having a tube with distal and proximal ends, an inflatable balloon carried on the tube, adjacent the distal tube end, and a fluid conduit ...


3
Erick T Engelson, John R Daniels: Valved catheter device and method. Target Therapeutics, Dressler Goldsmith Shore Sutker & Milnamow, March 21, 1989: US04813934 (193 worldwide citation)

A catheter device for accessing an internal body site along a small-diameter vessel path containing branch points in which the path may follow either the larger of smaller-diameter branch vessels. The device includes a catheter having a distal-end inflatable ballon and a distal-end aperture. A guide ...


4
Edward E Luck, John R Daniels: Non-antigenic collagen and articles of manufacture. Collagen Corporation, Bertram I Rowland, November 11, 1980: US04233360 (144 worldwide citation)

Collagen, available from domestic animals, is freed of noncollagen proteins, glycosaminoglycans and lipids by enzymatic treatment with a proteolytic enzyme to yield a product which is soluble in dilute acidic aqueous solutions (collagen in solution--CIS). The naturally occurring collagen is modified ...


5
Edward E Luck, John R Daniels: Non-antigenic collagen and articles of manufacture. December 18, 1984: US04488911 (108 worldwide citation)

Collagen, available from domestic animals, is freed of noncollagen proteins, glycosaminoglycans and lipids by enzymatic treatment with a proteolytic enzyme to yield a product which is soluble in dilute acidic aqueous solutions (collagen in solution--CIS). The naturally occurring collagen is modified ...


6
Edward E Luck, John R Daniels: Aqueous collagen composition. Collagen Corporation, Townsend and Townsend, February 20, 1979: US04140537 (107 worldwide citation)

The naturally occurring collagen is modified by removal of certain terminal peptide chains, which are described as telopeptides. The modified collagen, so derived, is described as atelopeptide collagen. Native collagen is immunogenic, while atelopeptide collagen is nonimmunogenic or possessed of a n ...


7
John R Daniels: Hyperthermic treatment of tumors. Target Therapeutics, Ciotti Murashige Irella & Manella, November 24, 1987: US04708718 (97 worldwide citation)

A method of treating a solid tumor, including the steps of localizing the tumor and the arterial vessel that supplies it, and injecting into the vessel, a vaso-occlusive collagen material adapted to produce occlusion of vessels having lumen diameters between about 10 and 150 microns. The injected ma ...


8
George Chu, John R Daniels: Collagen membranes for medical use. Collagen Corporation, Ciotti & Murashige Irell & Manella, February 16, 1988: US04725671 (81 worldwide citation)

Collagen membranes with desired properties are prepared by using a variety of gel-forming techniques in combination with methods for converting the gels to solid forms. The properties of these membranes or other solid forms may be further altered by cross-linking the collagen preparation either afte ...


9
Erik T Engelson, John R Daniels: Valved catheter device and method. Target Therapeutics, Morrison & Foerster, August 4, 1992: US05135494 (44 worldwide citation)

A catheter device for accessing an internal body site along a small-diameter vessel path containing branch points in which the path may follow either the larger of smaller-diameter branch vessels. The device includes a catheter having a distal-end inflatable balloon and an distal-end aperture. A gui ...


10
Edward E Luck, John R Daniels: Microwave sterilization of dry protein. Collagen Corporation, Bertram I Rowland, February 10, 1981: US04250139 (42 worldwide citation)

Method for decontaminating proteinaceous host materials from microorganisms, while retaining chemical, physical and physiological properties of said host proteinaceous materials, said method comprising substantially dehydrating said host proteinaceous material, preferably by lyophilization, and subj ...