1
Michael W Fountain, Steven J Weiss, John J Kearns, Alan L Weiner, Mircea C Popescu: Lipid matrix carriers for use in drug delivery systems. The Liposome Company, Pennie & Edmonds, September 9, 1986: US04610868 (142 worldwide citation)

Lipid matrix carriers are described which provide for the sustained release of bioactive agents in vivo or in vitro. The properties of the lipid matrix carriers of the present invention include high entrapment efficiencies; release of entrapped compounds in their active form; biodegradability and av ...


2
Andrew S Janoff, Thomas D Madden, Pieter R Cullis, John J Kearns, Anthony G Durning: Methods of preparing low-toxicity drug-lipid complexes. The Liposome Company, Burns Doane Swecker & Mathis, June 18, 2002: US06406713 (40 worldwide citation)

Methods and compositions are described for nonliposomal lipid complexes in association with toxic hydrophobic drugs such as the polyene antibiotic amphotericin B. Lipid compositions are preferably a combination of the phospholipids dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylgly ...


3
Paul A Tremblay, John J Kearns: Process for purification of phospholipids. The Liposome Company, Pennie & Edmonds, December 22, 1987: US04714571 (35 worldwide citation)

A process for the separation and purification of individual phospholipids, especially phosphatidylcholine or lecithin and phosphatidylethanolamine, from mixtures containing members of the sub-class of phosphatides, incorporating methods of solvent extraction appropriate to the scale of the sample an ...


4
Andrew S Janoff, Lawrence Boni, Thomas D Madden, Pieter R Cullis, Robert P Lenk, John J Kearns, Anthony G Durning, Robert Klimchak, Joel Portnoff: Low toxicity drug-lipid systems. The Liposome Company, Kenneth B Rubin, April 1, 1997: US05616334 (27 worldwide citation)

Methods and compositions are described for nonliposomal lipid complexes in association with toxic hydrophobic drugs such as the polyene antibiotic amphotericin B. Lipid compositions are preferably a combination of the phospholipids dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylgly ...


5
John J Kearns, Paul A Tremblay, Raymond J Robey, Swaminathan Sunder: Process for purification of phospholipids. Air Products and Chemicals, Richard A Dannells Jr, William F Marsh, James C Simmons, March 21, 1989: US04814111 (27 worldwide citation)

A process for the separation and purification of individual phospholipids, especially phosphatidylcholine or lecithin and phosphatidylethanolamine, from mixtures containing members of the sub-class of phosphatides, incorporating methods of solvent extraction appropriate to the scale of the sample an ...


6
John J Kearns, Paul A Tremblay: Process for purification of phospholipids. The Liposome Company, Allen Bloom, Catherine L Kurtz, January 28, 1992: US05084215 (21 worldwide citation)

A process for the separation and purification of individual phospholipids, especially phosphatidylcholine or lecithin and phosphatidylethanolaine, from mixtures containing members of the sub-class of phosphatides, incorporating methods of solvent extraction appropriate to the scale of the sample and ...


7
Paul A Tremblay, Robert L Suddith, John J Kearns: Phospholipid composition. The Liposome Company, Kenneth B Rubin, July 21, 1998: US05783210 (5 worldwide citation)

A composition having equal to or greater than about 97 percent by weight phosphatidylcholine and about equal to or less than about 3 percent by weight to about 0.5% sphingomylin and equal to or less than about 0.5% lysophosphatidylcholine (undetectable by UV at 205 nm) has been found to result in li ...


8
Paul A Tremblay, Robert L Suddith, John J Kearns: Phospholipid composition and liposomes made therefrom. The Liposome Company, Joanne Longo Feeney, July 4, 1995: US05429823 (2 worldwide citation)

A composition having equal to or greater than about 97 percent by weight phosphatidylcholine and about equal to or less than about 3 percent by weight to about 0.5% sphingomylin and equal to or less than about 0.5% lysophosphatidylcholine (undetectable by UV at 205 nm) has been found to result in li ...


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