1
James Aggen, John H Griffin, Mathai Mammen, Daniel Marquess, Edmund J Moran, David Oare: Muscarinic receptor antagonists. Theravance, Jeffrey A Hagenah, Joyce G Cohen, February 17, 2004: US06693202 (123 worldwide citation)

Disclosed are multibinding compounds which are muscarinic receptor antagonists. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is, independently of each other, a muscarinic receptor antagonist or an allosteric modu ...


2
Edmund J Moran, John H Griffin, Seok Ki Choi: &bgr;2-adrenergic receptor agonists. Theravance, David E Boone, Jeffrey A Hagenah, Roberta P Saxon, June 10, 2003: US06576793 (48 worldwide citation)

Disclosed are multibinding compounds which are &bgr;2 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma and bronchitis. They are also useful in the treatment of nervous system injury and premature labor.


3
John H Griffin: Multibinding inhibitors of microsomal triglyceride transferase protein. Advanced Medicine, Burns Doane Swecker & Mathis L, September 11, 2001: US06288234 (48 worldwide citation)

Disclosed are multibinding compounds which inhibit microsomal triglyceride transferase protein (MTP), a protein which mediates the transfer of lipids during the assembly of lipoproteins and related biomolecules. The multibinding compounds contain from 2 to 10 ligands covalently attached to one or mo ...


4
Edmund J Moran, John H Griffin, Seok Ki Choi: &bgr;2- adrenergic receptor agonists. Advanced Medicine, David E Boone, Jeffrey A Hagenah, March 26, 2002: US06362371 (28 worldwide citation)

The present invention is directed to multibinding compounds which are &bgr;2 adrenergic receptor agonists and are therefore useful in the treatment and prevention of respiratory diseases such asthma, bronchitis, and the like. They are also useful in the treatment of nervous system injury and prematu ...


5
John H Griffin, Andras Gruber: Assay methods for detecting serum proteases, particularly activated protein C. The Scripps Research Institute, Douglas A Bingham, Thomas Fitting, April C Logan, February 22, 1994: US05288612 (26 worldwide citation)

The invention describes diagnostic methods and compositions for determining the amount of protease in a body fluid sample. In particular, the invention detects proteases by a method in which both a reversible inhibitor of the protease and an irreversible inhibitor of interfering proteases during the ...


6
John H Griffin, Andras Gruber, Stephen R Hanson, Lawrence A Harker: Inhibition of arterial thrombotic occlusion or thromboembolism. Scripps Clinic and Research Foundation, Morgan & Finnegan, January 28, 1992: US05084274 (18 worldwide citation)

The method of preventing arterial thrombotic occulsion or thromboembolism by administering plasma-derived or recombinate produced protein C alone or in combination with a thrombolytic agent or combinations of thrombolytic agents.


7
John H Griffin, John L Pace: Multivalent macrolide antibiotics. Theravance, David E Boone, Jeffrey A Hagenah, Joyce Cohen, May 20, 2003: US06566509 (17 worldwide citation)

Disclosed are multibinding compounds which include macrolide antibiotics, aminoglycosides, lincosamides, oxazolidinones, streptogramins, tetracycline and/or other compounds at which bind to bacterial ribosomal RNA and/or to one or more proteins involved in ribosomal protein synthesis in the bacteriu ...


8
Daniel Marquess, Seok Ki Choi, David T Beattie, John H Griffin, Scott Armstrong, Timothy J Church, Thomas E Jenkins, David C Green: Sodium channel drugs and uses. Theravance, David E Boone, Jeffrey A Hagenah, Roberta P Saxon, November 12, 2002: US06479498 (16 worldwide citation)

The compounds of this invention comprise 2-10 ligands covalently connected, each of the ligands being capable of binding to a ligand binding site in a Na


9
Daniel Marquess, Seok Ki Choi, David T Beattie, John H Griffin, Scott Armstrong, Timothy J Church, Thomas E Jenkins: Sodium channel drugs and uses. Advanced Medicine, David E Boone, Jeffrey A Hagenah, Roberta P Saxon, July 16, 2002: US06420354 (15 worldwide citation)

The compounds of this invention comprise 2-10 ligands covalently connected, each of the ligands being capable of binding to a ligand binding site in a Na


10
John H Griffin, Rolf M Mesters: Activated protein C polypeptides and anti-peptide antibodies, diagnostic methods and systems for inhibiting activated protein C. The Scripps Research Institute, Douglas A Bingham, Thomas Fitting, April C Logan, January 18, 1994: US05279956 (15 worldwide citation)

The present invention describes APC polypeptides and anti-peptide antibodies capable of inhibiting activated Protein C anticoagulant activity. The polypeptide and antibody are useful in diagnostic methods and systems for measuring APC in vascular fluid samples. In addition, the polypeptide and anti- ...



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