1
John G Atwood, Albert C Mossa, Lisa M Goven, Fenton Williams, Timothy M Woudenberg, Marcel Margoulies, Robert P Ragusa, Richard Leath, Clive Miles: Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control. The Perkin Elmer Corporation, Davis Hoxie Faithfull & Hapgood, December 12, 1995: US05475610 (234 worldwide citation)

An instrument for performing highly accurate PCR employing a sample block in microtiter tray format. The sample block has local balance and local symmetry. A three zone film heater controlled by a computer and ramp cooling solenoid valves also controlled by the computer for gating coolant flow throu ...


2
John G Atwood, Albert C Mossa, Lisa M Goven, Fenton Williams, Timothy M Woudenberg, Marcel Margulies, Robert P Ragusa, Richard Leath, Clive Miles: Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control. The Perkin Elmer Corporation, Fish & Richardson P C, February 11, 1997: US05602756 (137 worldwide citation)

An instrument for performing highly accurate PCR employing a sample block in microtiter tray format. The sample block has local balance and local symmetry. A three zone film heater controlled by a computer and ramp cooling solenoid valves also controlled by the computer for gating coolant flow throu ...


3
Frederick A Ware, John B Dillon, Richard M Barth, Billy W Garrett Jr, John G Atwood Jr, Michael P Farmwald: Dynamic random access memory system. Rambus, Blakely Sokoloff Taylor & Zafman, July 4, 1995: US05430676 (106 worldwide citation)

As interfaces to DRAMs become more advanced and higher performance, the interfaces and signal lines required to support the interface become more expensive to implement. Therefore, it is desirable to minimize the number of signal lines and maximize the bandwidth of the signal lines interfacing to th ...


4
Frederick A Ware, John B Dillon, Richard M Barth, Billy W Garrett Jr, John G Atwood Jr, Michael P Farmwald: Dynamic random access memory system. Rambus, Blakely Sokoloff Taylor & Zafman, April 23, 1996: US05511024 (78 worldwide citation)

As interfaces to DRAMs become more advanced and higher performance, the interfaces and signal lines required to support the interface become more expensive to implement. Therefore, it is desirable to minimize the number of signal lines and maximize the bandwidth of the signal lines interfacing to th ...


5
John G Atwood, Hamilton W Marshall Jr, Peter H Heinz: Kinetic analyzer. The Perkin Elmer Corporation, Giarratana, F L Masselle, E T Grimes, October 4, 1977: US04052161 (75 worldwide citation)

A completely automated kinetic analyzer particularly suited for performing classical kinetic chemistries on an ultra-micro scale. The analyzer comprises a sample preparation unit and a photometric analytical unit. The preparation unit includes a rotationally indexed tray of sample containers present ...


6
Michael R Gambini, John G Atwood, Eugene F Young, Edward J Lakatos, Anthony L Cerrone: Instrument for monitoring polymerase chain reaction of DNA. Applera Corporation, Kilyk & Bowersox P L L C, November 16, 2004: US06818437 (59 worldwide citation)

An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vials to fluoresce the dye. An emissio ...


7
John G Atwood, Lawrence A Haff: In situ PCR amplification system. The Perkin Elmer Corporation, Edwin T Grimes, November 15, 1994: US05364790 (55 worldwide citation)

A complete in situ PCR system for amplification of nucleic acids contained in a prepared cell or tissue sample. The containment system for the PCR sample comprises a glass microscope slide, a specimen sample containing the target nucleic acid sequence mounted on the slide, a flexible plastic cover o ...


8
John G Atwood, Enrico Picozza: In situ PCR amplification system. The Perkin Elmer Corporation, Edwin T Grimes, David Aker, October 28, 1997: US05681741 (42 worldwide citation)

A complete in situ PCR system for amplification of nucleic acids contained in a prepared cell or tissue sample. The containment system for the PCR sample comprises a glass microscope slide, a specimen sample containing the target nucleic acid sequence mounted on the slide, a flexible plastic cover o ...


9
John G Atwood, Charles F DeMey III, Hamilton W Marshall Jr, Lucien C Ducret: Pipetting system for use in kinetic analysis apparatus and the like. The Perkin Elmer Corporation, Giarratana, F L Masselle, February 28, 1978: US04076503 (38 worldwide citation)

An automatic pipetting system for pipetting a measured micro-quantity of reagent into a reaction cup, in which the pipetter is lowered into a reagent bottle, a predetermined amount of reagent drawn in using a positive displacement pump, the pipetter withdrawn from the reagent bottle through an irrig ...


10
John G Atwood, Adrian Fawcett, Keith S Ferrara, Paul M Hetherington, Richard W Noreiks, Douglas E Olsen, John R Widomski, Charles M Wittmer: Thermal cycler for PCR. Applera Corporation, Kilyk & Bowersox P L L C, November 7, 2006: US07133726 (36 worldwide citation)

An instrument for PCR comprising an assembly, a heated cover, and a computer. The assembly can include a sample block, Peltier devices, and a heat sink, clamped together. The sample block temperature can be changed by controlling the Peltier devices with the computer. A perimeter heater can be used ...



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