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John E Starrett Jr, Muzammil M Mansuri, John C Martin, David R Tortolani, Joanne J Bronson: Prodrugs of phosphonates. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, Max D Hensley, September 2, 1997: US05663159 (95 worldwide citation)

There are disclosed novel oral prodrugs of phosphonate nucleotide analogs which are hydrolyzable under physiological conditions to yield compounds which are useful as antiviral agents, especially as agents effective against RNA and DNA viruses. They may also find use as antitumor agents.


2
John E Starrett Jr, Muzammil M Mansuri, John C Martin, David R Tortolani, Joanne J Bronson: Prodrugs of phosphonates. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, Max D Hensley, August 11, 1998: US05792756 (75 worldwide citation)

There are disclosed novel oral prodrugs of phosphonate nucleotide analogs which are hydrolyzable under physiological conditions to yield compounds which are useful as antiviral agents, especially as agents effective against RNA and DNA viruses. They may also find use as antitumor agents.


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John E Starrett Jr, Muzammil M Mansuri, David R Tortolani: Retinoid-like compounds. Bristol Myers Squibb Company, William T Han, June 4, 1996: US05523457 (42 worldwide citation)

This invention relates to a retinoid mpound of formula I ##STR1## in which Y is --CO--NH--, --CR.sup.2 .dbd.CR.sup.3 --, --CO--O--, --O--CO--, --C(.dbd.S)--NH--, --C.tbd.C--, --O--CH.sub.2 --, --CH.sub.2 --O--, or --CH.sub.2 --CH.sub.2 --;


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Jeffrey L Romine, Scott W Martin, Piyasena Hewawasam, Nicholas A Meanwell, Valentin K Gribkoff, John E Starrett Jr: Diphenyl oxadiazolones as potassium channel modulators. Bristol Myers Squibb Company, Aldo A Algieri, February 9, 1999: US05869509 (34 worldwide citation)

Novel compounds of Formula 1 are useful to treat disorders responsive to openers of the large conductance calcium-activated potassium channels: ##STR1## wherein "Het" is one of a select group of heterocyclic moieties; Z is independently for each occurrence selected from O or S; R.sup.a, R.sup.b and ...


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Jeffrey L Romine, Scott W Martin, Piyasena Hewawasam, Nicholas A Meanwell, Valentin K Gribkoff, John E Starrett Jr: Diphenyl imidazoles as potassium channel modulators. Bristol Myers Squibb Company, Aldo A Algieri, August 7, 2001: US06271249 (21 worldwide citation)

Novel compounds of Formula 1 are useful to treat disorders responsive to openers of the large conductance calcium-activated potassium channels:


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John E Starrett Jr, Kuo Long Yu, Muzammil M Mansuri, David R Tortolani, Peter R Reczek: Retinoid-like compounds. Bristol Myers Squibb Company, David M Morse, April 8, 1997: US05618839 (20 worldwide citation)

The present invention relates to a compound of formula I ##STR1## or a nontoxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof, in which


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Jeffrey L Romine, Scott W Martin, Piyasena Hewawasam, Nicholas A Meanwell, Valentin K Gribkoff, John E Starrett Jr: Diphenyl triazoles as potassium channel modulators. Bristol Myers Squibb Company, Aldo A Algieri, June 20, 2000: US06077861 (19 worldwide citation)

Novel compounds of Formula 1 are useful to treat disorders responsive to openers of the large conductance calcium-activated potassium channels: ##STR1## wherein "Het" is one of a select group of heterocyclic moieties; Z is independently for each occurrence selected from O or S; R.sup.a, R.sup.b and ...


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John E Starrett Jr, Kuo Long Yu, Muzammil M Mansuri, David R Tortolani, Peter R Reczek: Retinoid-like compounds. Bristol Myers Squibb Co, David M Morse, July 15, 1997: US05648385 (19 worldwide citation)

The present invention relates to a compound of formula ##STR1## or a nontoxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof, in which



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