1
Tao Wang, Zhongxing Zhang, Nicholas A Meanwell, John F Kadow, Zhiwei Yin, Qiufen May Xue, Alicia Regueiro Ren, John D Matiskella, Yasutsugu Ueda: Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives. Bristol Myers Squibb Company, John F Levis, Jennifer C Chapman, Samuel J DuBoff, April 8, 2008: US07354924 (32 worldwide citation)

This invention provides Compounds I having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in com ...


2
Jerzy Golik, John D Matiskella, Yasutsugu Ueda: Water-soluble prodrugs of azole compounds. Bristol Myers Squibb Company, David M Morse, May 22, 2001: US06235728 (25 worldwide citation)

Water soluble prodrugs of azole antifungal agents are provided by quaternizing a nitrogen atom of the azole ring with a phosphonooxymethyl group.


3
Chung Pin Chen, Timothy Paul Connolly, Laxma Reddy Kolla, John D Matiskella, Richard H Mueller, Yadagiri Pendri, Dejah T Petsch: Process for water soluble azole compounds. Bristol Myers Squibb Company, David M Morse, September 10, 2002: US06448401 (19 worldwide citation)

An improved process is provided for preparing water-soluble prodrugs of triazole antifungal compounds containing a secondary or tertiary hydroxyl group. More particularly, the improved process is directed toward preparation of water-soluble triazole antifungal compounds are provided having the gener ...


4
Joanne J Bronson, Stanley V D Andrea, Shelley E Hoeft, John D Matiskella, Peter F Misco Jr, Bing Y Luh, Dane M Springer, Yasutsugu Ueda, John A Wichtowski: Cephalosporin derviatives. Bristol Myers Squibb Company, David M Morse, April 15, 1997: US05620969 (11 worldwide citation)

Novel cephem derivatives represented by the general formula ##STR1## in which the Acyl substituent is a group of the formula ##STR2## wherein Ar is a lipophilic optionally substituted phenyl, naphthyl or pyridyl group; R.sup.1 represents either the residue of a heterocyclic amino acid or a C.sub.2 - ...


5
B Narasimhulu Naidu, Jacques Banville, Francis Beaulieu, Timothy P Connolly, Mark R Krystal, John D Matiskella, Carl Ouellet, Serge Plamondon, Roger Remillard, Margaret E Sorenson, Yasutsugu Ueda, Michael A Walker: Bicyclic heterocycles as HIV integrase inhibitors. Bristol Myers Squibb Company, James Epperson, February 13, 2007: US07176196 (11 worldwide citation)

The invention encompasses a series cyclic bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and ...


6
B Narasimhulu Naidu, Jacques Banville, John D Matiskella, Serge Plamondon, Yasutsugu Ueda: Bicyclic heterocycles as HIV integrase inhibitors. Bristol Myers Squibb Company, James Epperson, February 6, 2007: US07173022 (10 worldwide citation)

The invention encompasses a series cyclic bicyclic heterocyclic compounds of Formula I which are inhibitors of HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical composi ...


7
John D Matiskella, Stanley V D Andrea, Thomas W Hudyma, Yasutsugu Ueda, Oak K Kim, Raymond F Miller, Shelley E Hoeft, Joanne J Bronson: Cephalosporin derivatives. Bristol Meyers Squibb Company, David N Morse, July 25, 2000: US06093712 (10 worldwide citation)

Provided are cephem derivatives represented by the general formula ##STR1## wherein Ar, R.sup.1, R.sup.2, R.sup.3, R.sup.9 and R.sup.10 are as defined in the application. The derivatives are gram-positive antibacterial agents especially useful in the treatment of diseases caused by methicillin-resis ...


8
Tao Wang, Zhongxing Zhang, Nicholas A Meanwell, John F Kadow, Zhiwei Yin, Qiufen May Xue, Alicia Regueiro Ren, John D Matiskella, Yasutsugu Ueda: Composition and antiviral of substituted azaindoleoxoacetic piperazine derivatives. Bristol Myers Squibb Company, John F Levis, Jennifer C Chapman, Samuel J DuBoff, March 10, 2009: US07501420 (8 worldwide citation)

This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combi ...


9
B Narasimhulu Naidu, Jacques Banville, Francis Beaulieu, Timothy P Connolly, Mark R Krystal, John D Matiskella, Carl Ouellet, Serge Plamondon, Roger Remillard, Margaret E Sorenson, Yasutsugu Ueda, Michael A Walker: Bicyclic heterocycles as HIV integrase inhibitors. Bristol Myers Squibb Company, James Epperson, January 2, 2007: US07157447 (7 worldwide citation)

The invention encompasses a series bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods ...


10
Thomas A Montzka, John D Matiskella, Richard A Partyka: 14-Hydroxy-6-oxamorphinans and 14-hydroxy-6-oxaisomorphinans. Bristol Myers Company, Richard R Lloyd, October 14, 1980: US04228285 (6 worldwide citation)

14-Hydroxy-6-oxamorphinans and 14-hydroxy-6-oxaisomorphinans optionally substituted in the 3-, 7- and 17-positions have been found to possess potent analgetic, narcotic antagonist, antitussive and/or ADH inhibitory activity. The compounds are prepared by total synthesis and are not derived from opiu ...



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