1
Douglas N Modlin, Glenn R Edwards, John C Owicki, Michael T Taylor, Samuel A Marquiss: Sample analysis systems. Molecular Devices Corporation, Kolisch Hartwell P C, January 3, 2006: US06982431 (182 worldwide citation)

Systems, and components thereof, for analyzing samples. These systems include apparatus and methods for generating, transmitting, detecting, and/or analyzing light, including without limitation high-throughput optical screening devices for analyzing samples at one or more assay sites. These systems ...


2
Todd E French, Douglas N Modlin, John C Owicki, James S Richey, Lev J Leytes, Enal S Razvi: Methods and apparatus for detecting nucleic acid polymorphisms. LJL BioSystems, Kolisch Hartwell Dickinson McCormack & Heuser, October 2, 2001: US06297018 (150 worldwide citation)

Methods and apparatus for detecting polynucleotide hybridization in luminescence-based assays. The methods may include (1) allele-specific hybridization, using luminescence detection, (2) allele-specific oligonucleotide ligation, using dye-labeled oligonucleotide ligation with luminescence resonance ...


3
Douglas N Modlin, John C Owicki, Jon F Petersen, Todd E French, Carl L Wright, Jeanne A Ruiz, Lorne E Bechtel: Multi-mode light detection system. Molecular Devices Corporation, Kolisch Hartwell P C, November 30, 2004: US06825921 (108 worldwide citation)

Apparatus and methods for combining multiple modes and methods of optical detection, postprocessing, and/or feedback loops in bioanalytical measurements. The methods may include (1) positioning a composition at an examination site in a multi-mode instrument; (2) detecting light transmitted form the ...


4
John W Parce, Harden M McConnell, Gillian M K Humphries, Karen M Kercso, John C Owicki, Josef E Kercso: Methods for detecting the effect of cell affecting agents on living cells. Molecular Devices Corporation, Allegretti & Witcoff, January 11, 1994: US05278048 (94 worldwide citation)

Methods are disclosed for detecting the effects of cell affecting agents on living cells. The method steps include providing living cells that are retained in a micro flow chamber. The micro flow chamber is adapted for either continuous or intermittent flow of solutions or suspensions in intimate co ...


5
John W Parce, Harden M McConnell, Gillian M K Humphries, Karen M Kercso, John C Owicki, Josef E Kercso: Methods and apparatus for detecting the effect of cell affecting agents on living cells. Molecular Devices Corporation, Banner & Allegretti, March 5, 1996: US05496697 (62 worldwide citation)

Methods and apparatus are disclosed for detecting the effects of cell affecting agents on living cells. The method steps include providing living cells that are retained in a micro flow chamber. The micro flow chamber is adapted for either continuous or intermittent flow of solutions or suspensions ...


6

7
Douglas N Modlin, Todd E French, John C Owicki: Apparatus and methods for time-resolved spectroscopic measurements. LJL BioSystems, Kolisch Hartwell PC, November 19, 2002: US06483582 (30 worldwide citation)

Apparatus and methods for measuring light transmitted from a sample. The apparatus may include a stage, a light source, and a detector. The stage may be configured to hold a microplate having a plurality of sample wells. The apparatus may be configured to take frequency-domain time-resolved measurem ...


8
Douglas N Modlin, Jon F Petersen, John C Owicki: Apparatus and methods for spectroscopic measurements. LJL BioSystems, Kolisch Hartwell PC, October 15, 2002: US06466316 (21 worldwide citation)

Apparatus and methods for measuring light transmitted from a sample. The apparatus may include a stage, a light source, and a detector. The stage may be configured to hold a microplate having a plurality of sample wells. The apparatus may be configured to take measurements of one or more of absorban ...


9
Douglas N Modlin, Amer El Hage, John C Owicki: Devices and methods for sample analysis. LJL BioSystems, Kolisch Hartwell P C, November 26, 2002: US06486947 (19 worldwide citation)

Devices and methods for containing and analyzing small sample volumes that are sandwiched between solid surfaces. The devices may include an automated drive mechanism that controls the relative positions of the surfaces and an environmental-control mechanism that controls the humidity, temperature, ...


10
Albert K M Harris, Gregory L Kirk, John C Owicki, Timothy D Dawes, Richard C Kuo: Transverse flow plungers for microphysiometers. Molecular Devices, Banner & Allegretti, November 21, 1995: US05468605 (14 worldwide citation)

One aspect of the invention is the method of operating a microphysiometer including a plunger assembly having a plunger body with a microchamber at one end for receiving a sample and a passage in the plunger body communicating with the microchamber comprises passing a medium transversely through the ...