1
Tudor N Buican, John C Martin: Method and apparatus for simultaneously measuring a plurality of spectral wavelengths present in electromagnetic radiation. The United States of America represented by the United States Department of Energy, Samuel M Freund, Paul D Gaetjens, William P Moser, February 27, 1990: US04905169 (130 worldwide citation)

An apparatus and method simultaneously measures a plurality of spectral wavelengths present in electromagnetic radiation. A modulatable birefringent optical element is employed to divide a polarized light beam into two components, thereby producing a phase difference in two resulting light beams suc ...


2
John C Martin, James H Jett: Apparatus for eliminating background interference in fluorescence measurements. The United States of America represented by the United States Department of Energy, Lee W Huffman, Paul D Gaetjens, Judson R Hightower, March 4, 1986: US04573796 (122 worldwide citation)

The disclosure is directed to an apparatus for eliminating background interference during fluorescence measurements in a multiple laser flow cytometer. A biological particle stained with fluorescent dyes is excited by a laser. A fluorescence detector detects the fluorescence. The particle scatters l ...


3
James H Jett, Richard A Keller, John C Martin, Robert K Moyzis, Robert L Ratliff, E Brooks Shera, Carleton C Stewart: Method for rapid base sequencing in DNA and RNA. United States of America, Irell & Manella, October 9, 1990: US04962037 (103 worldwide citation)

A method is provided for the rapid base sequencing of DNA or RNA fragments wherein a single fragment of DNA or RNA is provided with identifiable bases and suspended in a moving flow stream. An exonuclease sequentially cleaves individual bases from the end of the suspended fragment. The moving flow s ...


4
Mark L Hammond, James H Jett, Richard A Keller, Babetta L Marrone, John C Martin: DNA fragment sizing and sorting by laser-induced fluorescence. The Regents of the Univ of California, Ray G Wilson, September 24, 1996: US05558998 (100 worldwide citation)

A method is provided for sizing DNA fragments using high speed detection systems, such as flow cytometry to determine unique characteristics of DNA pieces from a sample. In one characterization the DNA piece is fragmented at preselected sites to produce a plurality of DNA fragments. The DNA piece or ...


5
James H Jett, Richard A Keller, John C Martin, Richard G Posner, Babetta L Marrone, Mark L Hammond, Daniel J Simpson: Method for rapid base sequencing in DNA and RNA with two base labeling. The Regents of the University of California Office of Technology Transfer, Samuel M Freund, April 11, 1995: US05405747 (99 worldwide citation)

Method for rapid-base sequencing in DNA and RNA with two-base labeling and employing fluorescent detection of single molecules at two wavelengths. Bases modified to accept fluorescent labels are used to replicate a single DNA or RNA strand to be sequenced. The bases are then sequentially cleaved fro ...


6
John E Starrett Jr, Muzammil M Mansuri, John C Martin, David R Tortolani, Joanne J Bronson: Prodrugs of phosphonates. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, Max D Hensley, September 2, 1997: US05663159 (97 worldwide citation)

There are disclosed novel oral prodrugs of phosphonate nucleotide analogs which are hydrolyzable under physiological conditions to yield compounds which are useful as antiviral agents, especially as agents effective against RNA and DNA viruses. They may also find use as antitumor agents.


7
John C Martin, Tudor N Buican: Laser particle sorter. The United States of America represented by the United States Department of Energy, Ray G Wilson, Paul D Gaetjens, William R Moser, December 19, 1989: US04887721 (78 worldwide citation)

Method and apparatus for sorting particles, such as biological particles. A first laser defines an optical path having an intensity gradient which is effective to propel the particles along the path but which is sufficiently weak that the particles are not trapped in an axial direction. A probe lase ...


8
John E Starrett Jr, Muzammil M Mansuri, John C Martin, David R Tortolani, Joanne J Bronson: Prodrugs of phosphonates. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, Max D Hensley, August 11, 1998: US05792756 (76 worldwide citation)

There are disclosed novel oral prodrugs of phosphonate nucleotide analogs which are hydrolyzable under physiological conditions to yield compounds which are useful as antiviral agents, especially as agents effective against RNA and DNA viruses. They may also find use as antitumor agents.


9
Gregory Kaduchak, Greg Goddard, Gary Salzman, Dipen Sinha, John C Martin, Christopher Kwiatkowski, Steven Graves: Ultrasonic analyte concentration and application in flow cytometry. Los Alamos National Security, Mark N Fitzgerald, March 11, 2008: US07340957 (68 worldwide citation)

The present invention includes an apparatus and corresponding method for concentrating analytes within a fluid flowing through a tube using acoustic radiation pressure. The apparatus includes a function generator that outputs a radio frequency electrical signal to a transducer that transforms the ra ...


10
Julien P Verheyden, John C Martin: 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent. Syntex, Annette M Moore, Alan M Krubiner, October 19, 1982: US04355032 (59 worldwide citation)

The compound 9-(1,3-dihydroxy-2-propoxymethyl)guanine and the pharmaceutically acceptable salts thereof are useful as antiviral agents.



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