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Michael P Bevilacqua, John C Cheronis, Victor Tryon, Danute M Bankaitis Davis: Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles. Source Precision Medicine, Bromberg & Sunstein, November 15, 2005: US06964850 (64 worldwide citation)

Gene expression data, in particular gene expression profiles, are created and used in the identification, monitoring and treatment of disease and characterization of biological conditions. Profile data sets are derived from subject samples and include quantitative substantially repeatable measures o ...


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Lyle W Spruce, Albert C Gyorkos, John C Cheronis, Val S Goodfellow, Axel H Leimer, John M Young, James Ivan Gerrity: Cysteine protease inhibitors. Cortech, Dechert Price & Rhoads, December 21, 1999: US06004933 (61 worldwide citation)

The present invention relates to cysteine protease inhibitors of the general formula (I): ##STR1## wherein Z is a cysteine protease binding moiety; X and Y are S, O or optionally substituted N; and R.sub.1 is optionally substituted alkyl or aryl.


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Michael P Bevilacqua, Danute M Bankaitis Davis, John C Cheronis, Victor Tryon: Systems and methods for characterizing a biological condition or agent using precision gene expression profiles. Source Precision Medicine, Bromberg & Sunstein, February 17, 2004: US06692916 (48 worldwide citation)

Methods are provided for evaluating a biological condition of a subject using a calibrated profile data set derived from a data set having a plurality of members, each member being a quantitative measure of the amount of a subject's RNA or protein as distinct constituents in a panel of constitu ...


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Albert C Gyorkos, Lyle W Spruce, Axel H Leimer, John C Cheronis: Serine protease inhibitors comprising .alpha.-keto heterocycles. Cortech, Dechert, December 12, 2000: US06159938 (43 worldwide citation)

Provided are methods of inhibiting the activity of a serine protease using protease inhibitors that include an alpha-keto heterocycle in their structure. The methods are useful in the treatment of ischemic heart or treatment of symptoms associated with blood coagulation disorders. Also provided are ...


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Michael Bevilacqua, Danute M Bankaitis Davis, John C Cheronis, Victor Tryon: Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles. Source Precision Medicine, Bromberg & Sunstein, November 1, 2005: US06960439 (24 worldwide citation)

Gene expression data, in particular gene expression profiles, are created and used in the identification, monitoring and treatment of disease and characterization of biological conditions. Profile data sets are derived from subject samples and include quantitative substantially repeatable measures o ...


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John C Cheronis, Claire Coeshott: Immunogenic constructs comprising b-cell and t-cell epitopes on common carrier. Coretech, Schwegman Lundberg Woessner & Kluth P A, November 12, 1996: US05573916 (18 worldwide citation)

The present invention relates to immunogenic constructs capable of eliciting an IgG antibody response in a host in the absence of adjuvant.


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John C Cheronis, Albert Gyorkos, Lyle W Spruce, Eric T Whalley: Bradykinin antagonists. Cortech, Cushman Darby & Cushman IP Group of Pillsbury Madison & Sutro, December 1, 1998: US05843900 (15 worldwide citation)

The present invention relates to pharmaceutically effective heterodimers comprising a bradykinin antagonist component covalently linked to a mu-opioid agonist component.


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