1
John J Toole, Linda C Griffin, Louis C Bock, John A Latham: Aptamer analogs specific for biomolecules. Gilead Sciences, Mark L Bosse, November 24, 1998: US05840867 (83 worldwide citation)

Oligonucleotide sequences that mediate specific binding to selected target molecules and contain modified base, sugars, or sugar linkages are disclosed. Single-stranded DNA oligomers are obtained that bind to a series of biomolecules that differ in both size and composition. The range of target mole ...


2
Leon F Garcia Martinez, John A Latham, Ethan W Ojala, Corinne C Akatsuka, Pei Fan, Jeffrey T L Smith, Benjamin H Dutzar: Methods of preventing or treating pain using anti-NGF antibodies. Alderbio Holdings, LeClairRyan a professional corporation, Robin L Teskin, May 20, 2014: US08728473 (7 worldwide citation)

Antibodies and antibody fragments thereof with binding specificity to human Nerve Growth Factor (NGF) and methods of use for treating pain. Methods of treating pain or eliciting an analgesic effect comprising administering an effective amount of an anti-human NGF antibody or antibody fragment thereo ...


3
John A Latham, Ethan W Ojala, Jeffrey T L Smith, Benjamin H Dutzar, Leon F Garcia Martinez: Methods of preventing or treating pain using anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75. Alderbio Holdings, LeClairRyan a Professional Corporation, Robin L Teskin, December 16, 2014: US08911734 (2 worldwide citation)

NGF antagonists including antibodies and antibody fragments thereof having binding specificity to human Nerve Growth Factor (“NGF”), and methods of treating pain. Methods of treating pain or eliciting an analgesic effect in an individual comprising administering an effective amount of an NGF antagon ...


4
Leon F Garcia Martinez, Ann Elisabeth Carvalho Jensen, Katie Anderson, Benjamin H Dutzar, Ethan W Ojala, Brian R Kovacevich, John A Latham, Jeffrey T L Smith: Antibodies to IL-6 to inhibit or treat inflammation. ALDERBIO HOLDINGS, Robin L Teskin, LeClairRyan a Professional Corporation, July 21, 2015: US09085615 (1 worldwide citation)

The present invention is directed to therapeutic methods using IL-6 antagonists such as an Ab1 antibody or antibody fragment having binding specificity for IL-6 to prevent or treat disease or to improve survivability or quality of life of a patient in need thereof. In preferred embodiments these pat ...


5
Leon F Garcia Martinez, Benjamin H Dutzar, Ethan W Ojala, Jeffrey T L Smith, John A Latham: Methods of preventing inflammation and treating pain using anti-NGF compositions. ALDERBIO HOLDINGS, Robin L Teskin, LeClairRyan A Professional Corporation, October 10, 2017: US09783601

Monovalent agents, including Fab fragments and monovalent monoclonal antibodies analogous to MetMab, having binding specificity to human Nerve Growth Factor (“NGF”), and methods treating pain in an individual wherein there is no substantial increase in the inflammatory response of the individual fol ...


6
Benjamin H Dutzar, Brian R Kovacevich, Patricia Dianne McNeill, Danielle M Mitchell, Ethan W Ojala, Pei Fan, Jens Billgren, Erica A Stewart, Corinne C Akatsuka, Betty Yu Ching Chang, John A Latham, Leon F Garcia Martinez: Anti-NGF compositions and use thereof. ALDERBIO HOLDINGS, Robin L Teskin, LeClairRyan A Professional Corporation, October 10, 2017: US09783602

The present invention is directed to antibodies and fragments thereof having binding specificity for NGF. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and ...


7
Benjamin H Dutzar, Brian R Kovacevich, Patricia Dianne McNeill, Danielle M Mitchell, Ethan W Ojala, Pei Fan, Jens Billgren, Erica A Stewart, Corinne C Akatsuka, Betty Yu Ching Chang, John A Latham, Leon F Garcia Martinez: Anti-NGF compositions and use thereof. ALDERBIO HOLDINGS, Robin L Teskin, LeClairRyan A Professional Corporation, February 6, 2018: US09884909

The present invention is directed to antibodies and fragments thereof having binding specificity for NGF. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and ...


8
Leon F Garcia Martinez, Benjamin H Dutzar, Ethan W Ojala, Jeffrey T L Smith, John A Latham: Methods of preventing inflammation and treating pain using anti-NGF compositions. ALDERBIO HOLDINGS, Robin L Teskin, LeClairRyan A Professional Corporation, January 10, 2017: US09539324

This invention pertains to monovalent agents, including Fab fragments and monovalent monoclonal antibodies analogous to MetMab, having binding specificity to human Nerve Growth Factor (“NGF”), and methods of treating pain in an individual wherein there is no substantial increase in the inflammatory ...


9
Andrew Lawrence Feldhaus, Leon F Garcia Martinez, Benjamin H Dutzar, Ethan Wayne Ojala, Brian Robert Kovacevich, Katie Olson Anderson, Pei Fan, Jens Billgren, Erica Ann Stewart, Corinne C Akatsuka, Patricia Dianne McNeill, Danielle Marie Mitchell, Dan Scott Allison, John A Latham: Anti-PCSK9 antibodies and use thereof. ALDERBIO HOLDINGS, Robin L Teskin, LeClairRyan A Professional Corporation, February 9, 2016: US09255154

The present invention is directed to antibodies and fragments thereof having binding specificity for PCSK9. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, an ...


10
Leon F Garcia Martinez, Anne Elisabeth Carvalho Jensen, Katie Olson Anderson, Benjamin H Dutzar, Ethan Wayne Ojala, Brian R Kovacevich, John A Latham, Jeffrey T L Smith: Antibodies to IL-6 and use thereof. ALDERBIO HOLDINGS, Robin L Teskin, LeClairRyan A Professional Corporation, February 6, 2018: US09884912

The present invention is directed to antibodies and fragments thereof and humanized versions thereof having binding specificity for IL-6. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR pol ...