1
Nathan B Mantlo, Stephen T Schlachter, John A Josey: Substituted pyridine compounds and methods of use. Amgen, Steve Odre, Ron Levy, Frank Ungemach, February 8, 2000: US06022884 (86 worldwide citation)

Selected novel substituted pyridine compounds are effective for prophylaxis and treatment of diseases, such as TNF-.alpha., IL-1.beta., IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically ...


2
Nathan B Mantlo, Stephen T Schlachter, John A Josey: Substituted pyridine compounds and methods of use. Amgen, Frank S Ungemach, Stuart L Watt, December 25, 2001: US06333341 (22 worldwide citation)

Selected novel substituted pyridine compounds are effective for prophylaxis and treatment of diseases, such as TNF-&agr;, IL-1&bgr;, IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically ac ...


3
Nathan B Mantlo, Stephen T Schlachter, John A Josey: Substituted pyridine compounds and methods of use. Amgen, Richard V Person, Frank S Ungemach, Steven M Odre, October 1, 2002: US06458813 (13 worldwide citation)

Selected novel substituted pyridine compounds are effective for prophylaxis and treatment of diseases, such as TNF-&agr;, IL-1&bgr;, IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically ac ...


4
Kevin Koch, Andreas Termin, John A Josey: Carboxylic acid substituted heterocycles, derivatives thereof and methods of use. Amgen, Frank S Ungemach, Stuart L Watt, September 18, 2001: US06291450 (3 worldwide citation)

Selected novel carboxylic acid substituted heterocycle compounds are effective for prophylaxis and treatment of inflammation, tissue degradation, cancer, fibrosis and related diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmac ...


5
Nathan B Mantlo, Stephen T Schlachter, John A Josey: Substituted pyridine compounds and methods of use. Amgen, Frank Ungemach, Steven M Odre, February 6, 2001: US06184237 (2 worldwide citation)

Selected novel substituted pyridine compounds are effective for prophylaxis and treatment of diseases, such as TNF-&agr;, IL-1&bgr;, IL-6 and/or IL-8 mediated diseases, and other maladies, suchas pain and diabetes. The inventin encompasses novel compounds, analogs, prodrugs and pharmaceutically acce ...


6
Darryl David Dixon, Jonas Grina, John A Josey, James P Rizzi, Stephen T Schlachter, Eli M Wallace, Bin Wang, Paul Wehn, Rui Xu, Hanbiao Yang: Aryl ethers and uses thereof. PELOTON THERAPEUTICS, Wilson Sonsini Goodrich & Rosati, May 15, 2018: US09969689

The present disclosure relates to HIF-2α inhibitors and methods of making and using them for treating cancer. Certain compounds were potent in HIF-2α scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and led to tumor size reduction and regression in 786-O xenograft bearing mice ...


7
Kevin Koch, Andreas Termin, John A Josey: Carboxylic acid substituted heterocycles, derivatives thereof and methods of use. Amgen, Frank Ungemach, Steven M Odre, January 1, 2002: US06335329

Selected novel carboxylic acid substituted heterocycle compounds are effective for prophylaxis and treatment of inflammation, tissue degradation, cancer, fibrosis and related diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmac ...


8
Kevin Koch, Andreas Termin, John A Josey: Carboxylic acid substituted heterocycles, derivatives thereof and methods of use. Amgen, Frank S Ungemach, Richard V Person, July 15, 2003: US06593351

Selected novel carboxylic acid substituted heterocycle compounds are effective for prophylaxis and treatment of inflammation, tissue degradation, cancer, fibrosis and related diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmac ...


9
Kevin Koch, Andreas Termin, John A Josey: Carboxylic acid substituted heterocycles, derivatives thereof and methods of use. Amgen, Susan E Lingenfelter, April 4, 2006: US07022690

Selected novel carboxylic acid substituted heterocycle compounds are effective for prophylaxis and treatment of inflammation, tissue degradation, cancer, fibrosis and related diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmac ...


10
Kevin Koch, Andreas Termin, John A Josey: Carboxylic acid substituted heterocycles, derivatives thereof and methods of use. Amgen, Suzanne A Sprunger, January 4, 2005: US06838454

Selected novel carboxylic acid substituted heterocycle compounds are effective for prophylaxis and treatment of inflammation, tissue degradation, cancer, fibrosis and related diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmac ...