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Cristina Alonso Alija, Erwin Bischoff, Klaus Münter, Johannes Peter Stasch, Elke Stahl, Stefan Weigand, Achim Feurer: Carbamate-substituted pyrazolopyridines. Bayer HealthCare, February 6, 2007: US07173037 (66 worldwide citation)

The present invention relates to compounds which stimulate soluble guanylate cyclase, to the preparation thereof and to the use thereof as medicaments, in particular as medicaments for the treatment of cardiovascular disorders and/or sexual dysfunction.


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Alexander Straub, Chantal Fürstner, Thomas Jaetsch, Achim Feurer, Raimund Kast, Johannes Peter Stasch, Elisabeth Perzborn, Joachim Hütter, Klaus Dembowsky: Substituted pyrazole derivatives for the treatment of cardiocirculatory diseases. Bayer Aktiengesellschaft, Norris McLaughlin & Marcus, September 17, 2002: US06451805 (40 worldwide citation)

The present invention relates to new substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for the treatment of cardiovascular disorders.


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Peter Fey, Walter Hubsch, Jurgen Dressel, Rudolf Hanko, Thomas Kramer, Ulrich Muller, Matthias Muller Gliemann, Martin Beuck, Hilmar Bischoff, Stefan Wohlfeil, Dirk Denzer, Stanislav Kazda, Johannes Peter Stasch, Andreas Knorr, Siegfried Zaiss: Substituted mono- and bipyridylmethylpyridones. Bayer Aktiengesellschaft, Sprung Horn Kramer & Woods, April 18, 1995: US05407948 (38 worldwide citation)

Substituted mono- and bipyridylmethylpyridones are prepared either by reaction of pyridones with mono- or bipyridylmethylhalogen compounds or by reaction of pyridone-substituted halogenopyridines with tetrazolylphenylboronic acids. The substituted mono- and bipyridylmethylpyridones can be employed a ...


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Ulrich Rosentreter, Thomas Krämer, Andrea Vaupel, Walter Hübsch, Nicole Diedrichs, Thomas Krahn, Klaus Dembowsky, Johannes Peter Stasch, Mitsuyuki Shimada: Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines with adenosine receptor-binding activity and their use as cardiovascular preparations. Bayer Aktiengesellschaft, July 18, 2006: US07078417 (34 worldwide citation)

This application relates to pyridine derivatives having the general structure in which the several variables are as defined in the specification and claims, and to a process for preparing these compounds, a pharmacutical composition containing such compounds, and a method for using these materials f ...


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Cristina Alonso Alija, Markus Heil, Dietmar Flubacher, Paul Naab, Johannes Peter Stasch, Frank Wunder, Klaus Dembowsky, Elisabeth Perzborn, Elke Stahl: Derivatives of dicarboxylic acid having pharmaceutical properties. Bayer Aktiengesellschaft, March 8, 2005: US06864287 (32 worldwide citation)

The present invention relates to the compounds of the general formula (I) and their salts and stereoisomers for the production of medicaments for the treatment of cardiovascular disorders.


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Ulrich Rosentreter, Thomas Krämer, Andrea Vaupel, Walter Hübsch, Nicole Diedrichs, Thomas Krahn, Klaus Dembowsky, Johannes Peter Stasch, Mitsuyuki Shimada: Substituted 2-carba-3,5-dicyano-4-aryl-6-aminopyridines and the use of the same as selective ligands of the adenosine receptor. Bayer Aktiengesellschaft, October 31, 2006: US07129255 (32 worldwide citation)

This application relates to compounds of the formula wherein the groups R1–R6 are as defined in the specification and claims, and to a pharmaceutical composition containing the same, and to a method of using the same in treatment of cardiovascular disorders.