1
Eric A Swanson, David Huang, James G Fujimoto, Carmen A Puliafito, Charles P Lin, Joel S Schuman: Method and apparatus for optical imaging with means for controlling the longitudinal range of the sample. Massachusetts Institute of Technology, Wolf Greenfield & Sacks, June 14, 1994: US05321501 (787 worldwide citation)

A method and apparatus for performing optical imaging on a sample wherein longitudinal scanning or positioning in the sample is provided by either varying relative optical path lengths for an optical path leading to the sample and to a reference reflector, or by varying an optical characteristic of ...


2
Joel S Schuman, M Elizabeth Fini, Shravan K Chintala: Method of using matrix metalloproteinase inhibitors in filtering blebs following glaucoma filtering surgery and in the treatment of ischemic damage to the retina and optic nerve. New England Medical Center Hospitals, Barry J Marenberg, Ivor R Elrifi, Mintz Levin Cohn Ferris Glovsky and Popeo P C, January 7, 2003: US06503892 (4 worldwide citation)

This invention provides a method of inhibiting, preventing, and/or treating conjunctival filtering bleb leaks that may occur following glaucoma filtering surgery by administering Matrix Metalloproteinase inhibitors to glaucoma patients who have undergone such surgery. The invention additionally incl ...


3
Juan Xu, David Tolliver, Hiroshi Ishikawa, Chaim Gad Wollstein, Joel S Schuman: Blood vessel segmentation with three-dimensional spectral domain optical coherence tomography. University of Pittsburgh—Of the Commonwealth System of Higher Education, Carnegie Mellon University, Foley & Lardner, September 9, 2014: US08831304 (1 worldwide citation)

In the context of the early detection and monitoring of eye diseases, such as glaucoma and diabetic retinopathy, the use of optical coherence tomography presents the difficulty, with respect to blood vessel segmentation, of weak visibility of vessel pattern in the OCT fundus image. To address this p ...


4
Alan H Wells, Cecelia C Yates Binder, Joel S Schuman: Activators of CXCR3 for the treatment of angiopathies of the eye. University of Pittsburgh—Of the Commonwealth System of Higher Education, Klarquist Sparkman, September 27, 2016: US09452200 (1 worldwide citation)

The present disclosure describes methods of treating angiogenic disorders of the eye, such as macular degeneration, restenosis following glaucoma treatment or diabetic retinopathy, by administering an activator of C-X-C chemokine receptor 3 (CXCR3). In some embodiments, the activator of CXCR3 is int ...


5
Jong S Kim, Hiroshi Ishikawa, Joel S Schuman, Gadi Wollstein: Normalization of retinal nerve fiber layer thickness measurements made by time domain-optical coherence tomography. University of Pittsburgh—Of the Commonwealth System of Higher Education, Foley & Lardner, December 16, 2014: US08911089 (1 worldwide citation)

A scan location matching (SLM) method identifies conventional time domain optical coherence tomography (TD-OCT) circle scan locations within three-dimensional spectral domain OCT scan volumes. A technique uses both the SLM algorithm and a mathematical retinal nerve fiber bundle distribution (RNFBD) ...


6
Jong S Kim, Hiroshi Ishikawa, Joel S Schuman, Gadi Wollstein: Establishing compatibility between two- and three-dimensional optical coherence tomography scans. UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, Foley & Lardner, December 6, 2016: US09514513

Advances in optical coherence tomography (OCT) have prompted a transition from time domain OCT, providing 2D OCT images, to spectral domain OCT, which has a 3D imaging capability. Yet conventional technology offers little toward the goal of inter-device compatibility between extant 2D OCT images and ...


7
Weixang Dai, James L Funderburgh, Joel S Schuman, Nirmala SundarRaj: Inhibition of proliferation and fibrotic response of activated corneal stromal cells. University of Pittsburgh—of the Commonwealth System of Higher Education, The Webb Law Firm, August 26, 2014: US08815946

Provided herein are methods of preventing a fibrotic response and/or scarring in a wound, comprising administering to a subject a composition comprising an amount of an amide or ester of an alpha-ketoalkanoic acid effective to inhibit a proliferative and/or fibrotic response in the wound. In one ins ...


8
Alan H Wells, Cecelia C Yates Binder, Joel S Schuman: Activators of CXCR3 for the treatment of angiopathies of the eye. University of Pittsburgh Of The Commonwealth System of Higher Education, Klarquist Sparkman, November 10, 2015: US09180167

The present disclosure describes methods of treating angiogenic disorders of the eye, such as macular degeneration, restenosis following glaucoma treatment or diabetic retinopathy, by administering an activator of C-X-C chemokine receptor 3(CXCR3). In some embodiments, the activator of CXCR3 is inte ...


9
Kira L Lathrop, Joel S Schuman, Lawrence E Kagemann: Optical coherence tomography as a rapid, accurate, non-contact method of visualizing the palisades of Vogt. University of Pittsburgh—Of the Commonwealth System of Higher Education, Eckert Seamans Cherin & Mellott, Philip E Levy, May 29, 2018: US09980641

The innovation provides for a system and method available to image and visualize the palisades of Vogt via a non-contact process, analyze the image volumes acquired, evaluate the status of the palisades of Vogt from the data represented therein, and display the data in real-time or as a part of a me ...


10
Hiroshi Ishikawa, Joel S Schuman, Gadi Wollstein: System and method for visualizing a structure of interest. University of Pittsburgh of the Commonwealth System of Higher Education, Reed Smith, May 22, 2012: US08184885

A system. The system includes a computing device configured for communication with an imaging system and with a display device. The computing device includes a contour modeling module. The contour modeling module is configured for superimposing reference anchors on a cross-sectional image generated ...