1
Robert P Lenk, Anthony G Durning, Robert J Klimchak, Joel Portnoff, Michelle L Tomsho: Method for size separation of particles. The Liposome Company, Kenneth B Rubin, Rosanne Goodman, September 7, 1999: US05948441 (69 worldwide citation)

Tangential flow filtration is used in the size separation of particles, such as liposomes and lipid particles. These particles may be passed through a tangential flow filtration device of any pore size desired. Tangential flow filter systems of various pore sizes may be used sequentially to obtain p ...


2
Andrew S Janoff, Lawrence Boni, Thomas D Madden, Pieter R Cullis, Robert P Lenk, John J Kearns, Anthony G Durning, Robert Klimchak, Joel Portnoff: Low toxicity drug-lipid systems. The Liposome Company, Kenneth B Rubin, April 1, 1997: US05616334 (27 worldwide citation)

Methods and compositions are described for nonliposomal lipid complexes in association with toxic hydrophobic drugs such as the polyene antibiotic amphotericin B. Lipid compositions are preferably a combination of the phospholipids dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylgly ...


3
Lawrence Boni, Joel Portnoff: Taxane-containing phosphatidylcholine liposomes. The Liposome Company, Kenneth B Rubin, November 4, 1997: US05683715 (27 worldwide citation)

Provided herein are liposomal taxane formulations where the liposomal lipid is a phosphatidylcholine; these formulations are useful for treating animals afflicted with cancers.


4
Royden M Coe, Laura Edgerly Pflug, Lawrence Boni, Joel Portnoff, Sharma R Minchey: Method of producing liposomes. The Liposome Company, Kenneth B Rubin, July 30, 1996: US05540936 (21 worldwide citation)

This invention provides a process for the production of liposomes by combining an organic phase and an aqueous at a volume ratio of less than 3:1; the process can be conducted under conditions which obtain a single-modal population distribution of liposomes encompassing a pre-selected mean particle ...


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Andrew S Janoff, Thomas D Madden, Pieter R Cullis, John J Kearns, Anthony G Durning, Lawrence Boni, Robert P Lenk, Robert Klimchak, Joel Portnoff: Low toxicity drug-lipid systems. Burns Doane Swecker & Mathis, August 29, 2002: US20020119170-A1

Methods and compositions are described for nonliposomal lipid complexes in association with toxic hydrophobic drugs such as the polyene antibiotic amphotericin B. Lipid compositions are preferably a combination of the phospholipids dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylgly ...