1
Jeffrey R Sampson, Zohar H Yakhini, Peter G Webb, Nicholas M Sampas, Anna M Tsalenko, Joel Myerson: Method and mixture reagents for analyzing the nucleotide sequence of nucleic acids by mass spectrometry. Agilent Technologies, April 17, 2001: US06218118 (124 worldwide citation)

Methods and reagents are disclosed which satisfy the need for more sensitive, more accurate and higher through-put analyses of target nucleic acid sequences. The methods and reagents may be generically applied to generally any target nucleic acid sequence and do not require a priori information abou ...


2
Joel Myerson: Entrapped non-enzymatic macromolecules for chemical sensing. Hewlett Packard Company, Deborah A Neville, March 26, 1996: US05501836 (116 worldwide citation)

A sensor made of porous matrix or sol-gel glass and non-enzymatic macromolecular polymer immobilized in the sol-gel glass. The macromolecule is physically entangled or otherwise trapped, and does not leach regardless of exposure to elevated temperature and pressure. Surface effects are minimized sin ...


3
Joel Myerson: Entrapped non-enzymatic macromolecules for chemical sensing. Hewlett Packard Company, March 4, 1997: US05608006 (106 worldwide citation)

A sensor made of porous matrix or sol-gel glass and non-enzymatic macromolecular polymer immobilized in the sol-gel glass. The macromolecule is physically entangled or otherwise trapped, and does not leach regardless of exposure to elevated temperature and pressure. Surface effects are minimized sin ...


4
May Tom Moy, Joel Myerson, Karla M Robotti: Method and reagents for binding chemical analytes to a substrate surface, and related analytical devices and diagnostic techniques. Hewlett Packard Company, June 18, 1996: US05527711 (56 worldwide citation)

A method is provided for detecting an analyte of interest in a sample. The method involves binding the analyte to the surface of a substrate through a biotin-biotin binding protein interaction, contacting the surface-bound analyte with a quantitatively detectable analyte-binding moiety that binds th ...


5
Douglas J Dellinger, Agnieszka Sierzchala, John Turner, Joel Myerson, Zoltan Kupihar, Fernando Ferreira, Marvin H Caruthers, Geraldine F Dellinger: Thiocarbon-protecting groups for RNA synthesis. Agilent Technologies, June 19, 2012: US08202983 (41 worldwide citation)

Aspects of the invention include 2′ protected nucleoside monomers that are protected at the 2′ site with thiocarbon protecting groups. Thiocarbon protecting groups of interest include thiocarbonate, thionocarbonate, dithiocarbonate groups, as well as thionocarbamate protecting groups. Aspects of the ...


6
Joel Myerson: Increasing ionization efficiency in mass spectrometry. Agilent Technologies, April 6, 2004: US06716634 (33 worldwide citation)

A system for the analysis of polyionic molecules by mass spectrometry is provided. The polyionic molecule is attached to a charged tag which neutralizes some of the charge on the polyionic analyte. The formed adduct with a reduced net charge is then analyzed by mass spectrometry, and the determined ...


7
Karla M Robotti, Joel Myerson: Interface apparatus for capillary electrophoresis to a matrix-assisted-laser-desorption-ionization mass spectrometer. Hewlett Packard Company, December 3, 1996: US05580434 (29 worldwide citation)

An apparatus for collecting samples from capillary electrophoresis (CE) for matrix-assisted laser desorption ionization (MALDI) mass spectrometry (MS) is disclosed. The apparatus has a capillary, a metallic support, a porous member, and a power supply for applying an electrical potential between the ...


8
Philip W Barth, Daniel B Roitman, Joel Myerson: Adjustable nanopore, nanotome, and nanotweezer. Agilent Technologies, March 16, 2004: US06706203 (27 worldwide citation)

An adjustable nanopore is fabricated by placing the surfaces of two planar substrates in contact, wherein each substrate contains a hole having sharp corners and edges. A corner is brought into proximity with an edge to define a triangular aperture of variable area. Ionic current in a liquid solutio ...


9
H Bryan Bente, Alan C Herman, Joel Myerson, Benjamin G Shaw, Andrew Stefanski: Fluid proportioning pump system. Hewlett Packard Company, Edward Y Wong, December 22, 1987: US04714545 (24 worldwide citation)

A plurality of different liquid solutions are connected to an input of a pump system having at least two displacement chambers and in a manner to control the proportions of each constituent that are taken into each chamber during its intake stroke. The outputs of the chambers are connected to a comm ...


10
Jeffrey R Sampson, Joel Myerson: Cleavable oligonucleotide arrays. Agilent Technologies, November 6, 2007: US07291471 (18 worldwide citation)

Oligonucleotide arrays having features that include cleavable oligonucleotides are disclosed, as well as methods of making such arrays. Methods of synthesizing an oligonucleotide on a surface of a substrate are described.